A5101866366- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Metabolomics and Mass Spectrometry Studies
- Liver physiology and pathology
- Metabolism and Genetic Disorders
- Connective Tissue Growth Factor Research
- Alcohol Consumption and Health Effects
- Genomics, phytochemicals, and oxidative stress
- Autophagy in Disease and Therapy
- Lipid metabolism and disorders
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Mast cells and histamine
- Cell death mechanisms and regulation
- Endoplasmic Reticulum Stress and Disease
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Phytochemical and Pharmacological Studies
- Tryptophan and brain disorders
- Therapeutic Uses of Natural Elements
- Immunotoxicology and immune responses
- Pharmacological Effects of Medicinal Plants
- Cancer, Hypoxia, and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
Affiliated Hospital of Guizhou Medical University
2015-2022
Huazhong University of Science and Technology
2020-2021
Guiyang Medical University
2015-2021
Tongji Hospital
2020
Nanyang Medical College
2003-2015
Liver fibrosis is a worldwide health issue. Development of effective new drugs for treatment this disease great importance. This study investigated the therapeutic effects ferulic acid on liver in vitro and vivo.Human hepatic stellate cell line (HSC) LX-2 was used assays. Transforming growth factor β1 (TGF-β1) to induce cells. Western blot detect protein levels collagen I, fibronectin, α-smooth muscle actin (SMA), p-Smad2, p-Smad3, p-p38, p-JNK. Gene expression measured by RT-qPCR....
Liver fibrosis (LF) is a healing response to wounds resulting in liver injury that can cause failure or even cancer without functional prevention. Resveratrol (RSV) has been suggested exert biological effects against various human diseases. MicroRNA‑20a (miRNA/miR‑20a) shown promote disease progression. The present study aimed assess the mechanisms through which RSV induces autophagy and activates miR‑20a‑mediated phosphatase tensin homolog (PTEN)/PI3K/AKT signaling pathway LF. First, rat...
Consumption of alcohol is closely related to liver disease, such as hepatic fibrosis or even hepatocellular carcinoma (HCC). However, epidemiological and experimental studies indicated that consumption Maotai, one the famous liquors in China, exhibits no significant correlation with cirrhosis other beverage sources do. This study detected relationship Maotai HCC development a diethylnitrosamine (DEN)-initiated animal model. DEN was given mice at dose 100 mg/kg, ip, 50 ip following week. Mice...
Background: Forest therapy has been proven to have beneficial effects on people with depression and anxiety. However, it remains unknown whether the waterfall forest environment (WF) affects physical psychological health of patients chronic fatigue how WF regulates stress. Methods: Twenty-four were randomly divided into two groups: group urban (U) group. Scores Hamilton Anxiety Scale (HAMA), Depression (HAMD), Fatigue Scale-14 (FS-14) evaluated before after environmental intervention....
Abstract Background Nonalcoholic fatty liver disease (NAFLD) is the most prevalent and characterized by excessive fat accumulation. Kaili Sour Soup, a food typical of Guizhou Province, believed to have significant health benefits. Thus, we aimed identify assess impact Soup on NAFLD its underlying mechanism using integrative proteomic lipidomic analysis. Methods A high-fat diet male Wistar rats were used construct rat model. Haematoxylin eosin (HE) Oil Red O staining analyses perform...
Objective: To probe into the mechanism and interventional effects of silybin-phospholipid complex on amiodarone-induced steatosis in mice. Methods: Eight-week-old male C57BL/6 mice were divided three groups (5 each group): a control group (WT) with normal diet, model amiodarone 150mg/kg/d by oral gavage (AM), an intervention combined complex(AM+SILIPHOS. All fed their assigned diet for one week. Then, week later, serum alanine aminotransferase, aspartate triglyceride, total cholesterol...
BACKGROUNDIn rare cases, odontogenic keratocysts (ODs) transform into squamous cell carcinoma.Intervals between the first attendance of a patient and diagnosis OD with malignant transformation vary from weeks to years.In this article, we report case malignancy derived five-day delay in diagnosis. CASE SUMMARYA 54-year-old woman was referred Tongji Hospital Wuhan, China complaints moderate pain, recurrent swelling, pus discharge around her left maxillary lateral incisor for over 10...
To determine the risk factor of HCC in Guizhou.A group case-control study design was conducted between 762 cases and 798 controls Guizhou province. The main related-factors were analyzed with unconditional logistic regression model evaluated by odds ratio (OR) 95% confidence interval (95% CI).There are significant differences regarding to cigarette smoking 210 (27.6%),non-alcoholic fatty liver disease 336 (44.1%), alcoholic 245 (32.2%), family history 141 (16.5%), alcohol consumption 300...
Abstract Exploring the expression of miR-571 in patients with liver fibrosis and its role progression fibrosis. A total 74 chronic hepatitis cirrhosis accompanied by our institution from September to December 2018 were collected for study, different progressions was determined RT-PCR Western blot analysis. Set up Notch3 group down regulated group, used determine effect Notch signaling on fibrogenic α-SMA, collagen I. CCK-8, cell scratch assays, Transwell flow cytometry LX-2 proliferation,...
To study the protective effect of Blueberry against rat hepatic fibrosis and on HO-1 expression patterns.A total 45 SD rats were randomly divided into five groups namely control group (group A), model B), blueberry C), Dan-shao-hua-xian (DSHX) capsule D) +Dan-shao-hua-xian E). Fibrous liver models in induced by subcutaneous injection CCl4 high-lipid/low-protein diet for 8 weeks except which accepted saline alone. The level alanine aminotransferase (ALT) serum was examined. activities...
Abstract Background Human placental extracts (HPE) have been documented to facilitate the healing of certain disorders including allergy. However, effects HPE on functionality mast cells, a critical cell type in allergic diseases, not reported. Methods To investigate regulation allergy with respect biological functions line C57 cells were treated followed by assessment proliferation, apoptosis, activation, chemotaxis and phagocytosis. Mouse peritoneal also investigated for their responses...
Abstract Background Primary squamous cell carcinoma rarely occurs in parotid gland. Partial, superficial or total parotidectomy as well radical resection is performed based on patients’ conditions. For patients with symptoms of facial nerve weakness dysfunction, preservation considered justifiably, whereas groundlessly if the malignancy asymptomatic. We hereby reported a case symptomatic primary and preservation. Case summary With complaint an asymptomatic mass right gland for five years it...