A5103220533- Nanoplatforms for cancer theranostics
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Electrospun Nanofibers in Biomedical Applications
- Nanoparticle-Based Drug Delivery
- Bone Tissue Engineering Materials
- Graphene and Nanomaterials Applications
- Anesthesia and Pain Management
- Photodynamic Therapy Research Studies
- 3D Printing in Biomedical Research
- Circular RNAs in diseases
- Hydrogels: synthesis, properties, applications
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Pain Mechanisms and Treatments
- Advanced Drug Delivery Systems
- Luminescence Properties of Advanced Materials
- Spectroscopy Techniques in Biomedical and Chemical Research
- Quantum Dots Synthesis And Properties
- Advanced biosensing and bioanalysis techniques
- Chalcogenide Semiconductor Thin Films
- Magnetic Properties and Applications
- Laser Applications in Dentistry and Medicine
- Magnetic properties of thin films
- Intraocular Surgery and Lenses
Universidad de Zaragoza
2014-2022
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2016-2022
Instituto de Nanociencia y Materiales de Aragón
2014-2022
Consejo Superior de Investigaciones Científicas
2019-2020
Instituto de Investigación Sanitaria Aragón
2017-2019
The continuous synthesis of biodegradable photothermal copper sulfide nanoparticles has been carried out with the aid a microfluidic platform. A comparative physicochemical characterization resulting products from microreactor and conventional batch reactor performed. is able to operate in manner 4-fold reduction times compared that producing same requirements. Biodegradation subproducts obtained under simulated physiological conditions have identified, complete cytotoxicological analysis on...
Tumor-derived extracellular vesicles (EVs) are secreted in large amounts into biological fluids of cancer patients. The analysis EVs cargoes has been associated with patient´s outcome and response to therapy. However, current technologies for isolation tedious low cost-efficient routine clinical implementation. To explore the value circulating we attempted a proof-of-concept endometrial (EC) ExoGAG, an easy use highly efficient new technology enrich EVs. Technical performance was first...
Herein, we report a straightforward method for the scalable preparation of Pd nanoparticles (Pd-NPs) with reduced inherent cytotoxicity and high photothermal conversion capacity. These Pd-NPs are rapidly taken up by cells able to kill labeled cancer upon short exposure near-infrared (NIR) light. Following cell treatment Pd-NPs, ablated areas were patterned precision laser scanning microscopy, allowing one perform migration assays unprecedented accuracy. Using coherent Raman containing...
Synergistic antimicrobial effects were observed for copper sulfide (CuS) nanoparticles together with indocyanine green (ICG) in the elimination of wild type pathogenic bacteria (Staphylococcus aureus ATCC 29213 and Pseudomonas aeruginosa 27853) also opportunistic fungal infective yeast (Candida albicans 10231). Furthermore, large antibacterial clinical isolates Methicillin-resistant S. (MRSA) PFGE strain-type USA300. This efficient action was attributed to combined extra- intracellular...
The optical and morphological properties of hollow gold nanoparticles (HGNPs) can be finely modified by employing poly-l-lysine hydrobromide (PLL), a homopoly amino acid the l-lysine, used as reducer stabilizer. We demonstrate that reshaping these plasmonic nanostructures responds to an Ostwald ripening process in which initial HGNPs dissolve under acidic conditions provided PLL generating chloroaurate ions. These ions are then reduced primary amines itself produce metallic gold, is...
The development of thermoresponsive nanogels loaded with nanocrystals the local anesthetic bupivacaine (BNCs) for prolonged peripheral nerve pain relief is reported here. BNCs were prepared using antisolvent precipitation method from hydrophobic form (bupivacaine free base). as-prepared used stand-alone or encapsulated in temperature-responsive poly(ethylene glycol) methyl ether methacrylate (OEGMA)-based nanogels, resulting NC-loaded (BNC-nanogels) monodisperse size. synthesis protocol has...
Common photosensitizers used in photodynamic therapy do not penetrate the skin effectively. In addition, visible blue and red lights to excite such have shallow penetration depths through tissue. To overcome these limitations, we synthesized ultraviolet- visible-light-emitting, energy-transfer-based upconversion nanoparticles coencapsulated them inside PLGA-PEG (methoxy poly(ethylene glycol)-b-poly(lactic-co-glycolic acid)) with photosensitizer protoporphyrin IX. Nd3+ has been introduced as...
Aim: Developing hybrid poly(N-isopropylacrylamide)-based nanogels decorated with plasmonic hollow gold nanoparticles for on-demand drug delivery and their physico-chemical characterization, bupivacaine loading release ability upon light irradiation, in vitro cell viability. Materials & methods: Hollow were prepared by galvanic replacement reaction; synthesized via precipitation polymerization electrostatic coupling was accomplished using poly(allylamine hydrochloride) as cationic...
ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to Microfluidic Synthesis and Biological Evaluation of Photothermal Biodegradable Copper Sulfide NanoparticlesIsabel Ortiz de Solorzano, Martín Prieto, Gracia Mendoza, Teresa Alejo, Silvia Irusta, Victor Sebastian*, Manuel Arruebo*Cite this: ACS Appl. Mater. Interfaces 2016, 8, 37, 24982Publication Date (Web):September 6, 2016Publication History Published online6 September...
The optical and morphological properties of hollow gold nanoparticles (HGNPs) can be finely modified by employing Poly-L-Lysine hydrobromide (PLL), an homo poly aminoacid the L-lysine, used as reducer stabilizer. We investigate locally plasmonic response these nanostructures electron energy loss spectroscopy (EELS). plasmon excitations are interpreted discrete dipolar approximation (DDA) simulations. demonstrate that this controlled top-down modification a fine tuning is possible. Unlike...