A5070365288- SARS-CoV-2 and COVID-19 Research
- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Heart Failure Treatment and Management
- Acute Myocardial Infarction Research
- Cardiac electrophysiology and arrhythmias
- Bacterial Identification and Susceptibility Testing
- Cardiac Structural Anomalies and Repair
- Hemodynamic Monitoring and Therapy
- Cell Image Analysis Techniques
- Biosensors and Analytical Detection
- Long-Term Effects of COVID-19
- COVID-19 diagnosis using AI
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Metabolomics and Mass Spectrometry Studies
- Cardiovascular Function and Risk Factors
- Neurological Disease Mechanisms and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
Heidelberg University
2017-2024
University Hospital Heidelberg
2019-2024
University Medical Centre Mannheim
2017-2024
University Medical Center
2021
AstraZeneca (United States)
2019
Abstract During the ongoing COVID-19 pandemic, PCR testing and antigen tests have proven critical for helping to stem spread of its causative agent, SARS-CoV-2. However, these methods suffer from either general applicability and/or sensitivity. Moreover, emergence variant strains creates need flexibility correctly efficiently diagnose presence substrains. To address needs we developed diagnostic test ADESSO (Accurate Detection Evolving SARS-CoV-2 through SHERLOCK (Specific High Sensitivity...
IntroductionThe longevity of antibody levels against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the duration immunity are current topics major scientific interest. Antibody kinetics during phase well studied, whereas long-term yet to be determined, with contradictory results from studies date. Here, we present a longitudinal analysis serological responses SARS-CoV-2 infection following convalescence association post-COVID (PCS).Materials methodsA total 237 serum samples...
Studies investigating the prognostic role of platelets commonly include critically ill patients, whereas data regarding impact platelet count in patients admitted with sepsis and septic shock is limited. Therefore, study investigates shock. Consecutive from 2019 to 2021 were included monocentrically. Blood samples retrieved day disease onset (day 1), days 2, 3, 5, 7 10. Firstly, diagnostic value was tested for compared sepsis. Secondly, 30-day all-cause mortality. Statistical analyses...
This study examines the prognostic impact of C-reactive protein (CRP) and white blood cell (WBC) counts in patients with cardiogenic shock (CS). Data regarding inflammatory biomarkers CS are scarce. All consecutive from 2019 to 2021 admitted a cardiac intensive care unit (ICU) were included at one institution. Laboratory measurements retrieved day admission (i.e., 1), as well days 2, 3, 4, 8. The primary endpoint was 30-day all-cause mortality. Statistical analyses univariate t-tests,...
In patients with cardiogenic shock (CS) due to myocardial infarction, elevated lactate levels are known be negative predictors. Studies regarding the prognostic impact in CS complicated by out-of-hospital cardiac arrest (OHCA) limited. Two hundred and sixty-three consecutive were included. The value of on days 1, 2, 3, 4 8 was tested stratified OHCA non-OHCA. Statistical analyses included univariable t-test, Spearman's correlation, C-statistics, Kaplan-Meier analyses, as well multivariable...
Studies investigating the diagnostic and prognostic value of neutrophil-to-lymphocyte ratio (NLR) in sepsis or septic shock commonly included preselected subgroups patients were published prior to current sepsis-3 criteria. Therefore, this study investigates impact NLR with shock.Consecutive from 2019 2021 prospective "MARSS-registry" monocentrically. First, compared established scores was tested for sepsis. Second, regard positive blood cultures tested. Thereafter, 30-day all-cause...
This study investigates the prognostic value of cardiac troponin I (cTNI) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels in patients with cardiogenic shock (CS). Data regarding biomarkers CS is scarce, furthermore, most studies were restricted to acute myocardial infarction (AMI). Therefore, consecutive from 2019 2021 included. Blood samples retrieved day disease onset (day 1) on days 2, 3 4 thereafter. The cTNI NT-proBNP was tested for 30-day all-cause mortality....
Hyaluronan receptor LYVE-1 is expressed by liver sinusoidal endothelial cells (LSEC), lymphatic and specialized macrophages. Besides binding to hyaluronan, can mediate adhesion of leukocytes cancer cells. Here, we assessed the impact on physiological functions metastasis.Mice with deficiency Lyve-1 (Lyve-1-KO) were analyzed using histology, immunofluorescence, microarray analysis, plasma proteomics flow cytometry. Liver metastasis was studied intrasplenic/intravenous injection melanoma...
ObjectiveNumerous immunoassays for detecting antibodies directed against SARS-CoV-2 have been rapidly developed and released. Validations of these performed with a limited number samples. The lack standardisation might lead to significantly different results. This study compared ten automated assays from six vendors in terms sensitivity, specificity reproducibility.MethodsThis fully the following vendors: Diasorin, Epitope Diagnostics, Euroimmun, Roche, YHLO, Snibe. retrospective part...
In multiple sclerosis (MS), iron rim lesions (IRLs) are associated with pronounced tissue damage, higher disease severity and have been suggested as an imaging marker of chronic active inflammation behind the blood-brain barrier indicating progression. Furthermore, intrathecal compartmentalized has to be a mediator cerebrospinal fluid (CSF)-related damage.To investigate CSF markers in patients at least one IRL compared without IRLs damage normal-appearing white matter (NAWM) proximity...
Longitudinal humoral SARS-CoV-2 (severe acute respiratory syndrome coronavirus type 2) immunity for up to 15 months due vaccination, the efficacy of vaccination strategies (homologous, vector-vector versus heterologous, vector-mRNA), influence side effects, and infection rate in German healthcare workers need be investigated.In this study, 103 individuals vaccinated against were enrolled examine their anti-SARS-CoV-2 anti-N- anti-RBD/S1-Ig levels. A total 415 blood samples lithium heparin...
Introduction: The presence of acute kidney injury (AKI) was shown to increase the risk mortality following myocardial infarction (AMI), however, data regarding prognostic impact AKI in patients with concomitant cardiogenic shock (CS) is limited. study investigates predictors and CS. Methods: Consecutive CS from 2019 2021 were included at one institution. Laboratory values retrieved day disease onset (day 1) days 2, 3, 4 8 thereafter. Predictors for (defined as an plasma creatinine > 50%...
Background: The aim of the rapid introduction vaccines during COVID-19 pandemic was a reduction in SARS-CoV-2 transmission and less frequent occurrence severe courses. Thus, we evaluated severity vaccinated individuals to examine variant-specific symptom characteristics their clinical impact on serological immune response. Methods: A total 185 previously against infected with Delta (B.1.617.2) or Omicron (BA.4 BA.5) variant, were enrolled for anti-SARS-CoV-2 anti-N- anti-RBD/S1-Ig level...
Abstract Objective The present study aims to clarify the prevalence and prognostic impact of anaemia iron deficiency in patients with heart failure mildly reduced ejection fraction (HFmrEF). Background HFmrEF has not yet been clarified. Methods Consecutive were retrospectively included at one institution from 2016 2022. Patients (i.e. haemoglobin <13 g/dL males < 12 females) compared without, respectively or without deficiency. primary endpoint was all‐cause mortality 30 months (median...
Serum biomarker S100B has been explored for its potential benefit to improve clinical decision-making in the management of patients suffering from traumatic brain injury (TBI), especially as a pre-head computed-tomography screening test with mild TBI. Although being already included into some guidelines, implementation standard care is still lacking. This might be explained by turnaround time (TAT) too long serum used emergency settings.S100B concentrations were determined 136 matching pairs...
Data regarding the prognostic value of cardiac biomarkers in patients suffering from sepsis or septic shock is scarce. Studies investigating role with and were commonly published prior to sepsis-3 criteria often not restricted only, too. This study investigated diagnostic aminoterminal pro-B-type Natriuretic Peptide (NT-pro BNP) troponin I (cTNI) shock. Consecutive included 2019 2021. Blood samples retrieved day disease onset (i.e., 1), 2 3. Firstly, NT-pro BNP cTNI diagnose was tested....
Studies investigating the diagnostic and prognostic value of D-dimer levels disseminated intravascular coagulation (DIC) score in sepsis or septic shock commonly include preselected subgroups patients were published prior to current sepsis-3 criteria. Therefore, this study investigates impact DIC with shock.Consecutive enrolled prospective monocentric "MARSS" registry from 2019 2021 included. First, was compared discriminate without shock. Thereafter, tested for 30-day all-cause mortality....
Objectives To evaluate the prognostic value of fully automatic lung quantification based on spectral computed tomography (CT) and laboratory parameters for combined outcome prediction in COVID-19 pneumonia. Methods CT images 53 hospitalized patients including virtual monochromatic reconstructions at 40-140keV were analyzed using a automated software system. Quantitative (QCT) mean percentiles density, fibrosis index (FIBI -700 , defined as percentage segmented voxels ≥-700 HU), ground-glass...
Background In recent years, remarkable progress has been made in deep learning technology and successful use cases have introduced the medical domain. However, not many studies considered high-performance computing to fully appreciate capability of technology. Objective This paper aims design a solution accelerate an automated Gram stain image interpretation by means framework without additional hardware resources. Methods We will apply evaluate 3 methodologies, namely fine-tuning, integer...
This study investigates the prognostic value of aspartate-to-alanine aminotransferase ratio (i.e., AST/ALT ratio) and bilirubin in patients with cardiogenic shock (CS). Despite ongoing improvements regarding treatment CS patients, invasive care unit (ICU) mortality remains unacceptably high. Limited data suffering from is available. The authors hypothesize measurement liver enzymes during course may be an easy feasible method to assess right-heart dysfunction prognosis CS. Consecutive 2019...
Background Only few data evaluating the prognostic impact of blood-derived potassium levels (K) on arrhythmic endpoints in patients with implantable cardioverter-defibrillators (ICD) is available. Therefore, this study evaluates recurrences ventricular tachyarrhythmias consecutive ICD recipients. Methods A large retrospective registry was used including all presenting admission from 2002 to 2016 at one institution. Patients were divided into three subgroups: hypokalemia (i.e., K 4.5 mmol/L)....
The detection of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is mandatory for the diagnosis, retrospective assessment disease progression, and correct evaluation current infection situation in population. Many such assays have been launched by various manufacturers. Unfortunately, new US Food Drug Administration emergency use regulations resulted a where laboratories perform their own validation studies but many these do not biobank needed conduct studies.