A5063428116- Pancreatic function and diabetes
- Endoplasmic Reticulum Stress and Disease
- Adipose Tissue and Metabolism
- Diabetes Management and Research
- Cannabis and Cannabinoid Research
- Mental Health Treatment and Access
- Regulation of Appetite and Obesity
- Education and Military Integration
- Posttraumatic Stress Disorder Research
- Metabolism, Diabetes, and Cancer
- Diet, Metabolism, and Disease
- Diabetes and associated disorders
- Suicide and Self-Harm Studies
- Cell death mechanisms and regulation
- Employment and Welfare Studies
- Counseling Practices and Supervision
- Receptor Mechanisms and Signaling
- Cellular transport and secretion
- 3D Printing in Biomedical Research
- Vagus Nerve Stimulation Research
- Advanced Breast Cancer Therapies
- Neuroendocrine Tumor Research Advances
- Psychiatric care and mental health services
- Defense, Military, and Policy Studies
- Health Policy Implementation Science
Icahn School of Medicine at Mount Sinai
2016-2024
Cornell University
2024
New York Proton Center
2018-2021
The Bronx Defenders
2020-2021
Institute of Nutrition, Metabolism and Diabetes
2020
Five hundred thirty-seven million people globally suffer from diabetes. Insulin-producing β cells are reduced in number most with diabetes, but individuals still have some residual cells. However, none of the many diabetes drugs common use increases human cell numbers. Recently, small molecules that inhibit dual tyrosine-regulated kinase 1A (DYRK1A) been shown to induce immunohistochemical markers replication, and this is enhanced by stimulate glucagon-like peptide 1 (GLP1) receptor (GLP1R)...
Understanding the detailed anatomy of endocrine pancreas, its innervation, and remodeling that occurs in diabetes can provide new insights into metabolic disease. Using tissue clearing whole-organ imaging, we identified 3D associations between islets innervation. This technique provided quantification α β cell volumes pancreatic nerve fibers, their distribution heterogeneity healthy tissue, canonical mouse models diabetes, samples from normal diabetic human pancreata. Innervation was highly...
Aims/Hypothesis Finding ways to stimulate the regeneration of endogenous pancreatic beta cells is an important goal in treatment diabetes. Parathyroid hormone-related protein (PTHrP), full-length (1–139) and amino-terminal (1–36) peptides, enhance cell function, proliferation, survival. Therefore, we hypothesize that PTHrP(1–36) has potential regenerate cells. Methods The partial pancreatectomy (PPx) mouse model injury was used test this hypothesis. Male Balb/c mice underwent either...
Treatment for type 1 diabetes (T1D) requires stimulation of functional β cell regeneration and survival under stress. Previously, we showed that inhibition the RANKL/RANK [receptor activator nuclear factor kappa Β (NF-κB) ligand] pathway, by osteoprotegerin anti-osteoporotic drug denosumab, induces rodent human proliferation. We demonstrate RANK pathway mediates cytokine-induced death through RANK-TRAF6 interaction induction NF-κB activation. Osteoprotegerin denosumab protected cells against...
Abstract Genetic deletion of cyclin-dependent kinase 4 (Cdk4) is associated with pancreatic beta cell loss and glucose dysregulation in rodents. Palbociclib, one the first selective CDK4/6 inhibitors approved for treatment advanced breast cancer, currently being investigated as an adjuvant patients early-stage cancer a variety cancers covering wide-range patient populations. Hence, longer chronic toxicity studies were necessary to further examine its safety profile. The effects different...
Diabetes occurs due to a loss of functional β-cells, resulting from β-cell death and dysfunction. Lactogens protect rodent human β-cells in vitro vivo against triggers cytotoxicity relevant diabetes, many which converge onto common pathway endoplasmic reticulum (ER) stress. However, whether lactogens modulate the ER stress is unknown. This study examines can mitigate diabetes incidence Akita (Ak) mice, model stress-induced akin neonatal humans. We show that INS-1 cells, primary two distinct...
Abstract Behavioral adaptations to environmental threats are crucial for survival and necessitate rapid deployment of energy reserves. The amygdala coordinates behavioral threats, but little is known about its involvement in underpinning metabolic adaptations. Here, we show that acute stress activates medial (MeA) neurons innervate the ventromedial hypothalamus (MeAVMH neurons), which precipitates hyperglycemia hypophagia. glycemic actions MeAVMH occur independent adrenal or pancreatic...
Hypoglycemia is a frequent complication of diabetes, limiting therapy and increasing morbidity mortality. With recurrent hypoglycemia, the counterregulatory response (CRR) to decreased blood glucose blunted, resulting in hypoglycemia-associated autonomic failure (HAAF). The mechanisms leading these blunted effects are only poorly understood. Here, we report, with ISH, IHC, tissue-clearing capability iDISCO+, that growth hormone releasing (GHRH) neurons represent unique population arcuate...
Mental health services provide essential supports to people living with psychiatric disorders. However, in the United States as a whole and New York City particular, use of mental is low care not equitably distributed. To advance policy strategy for addressing gaps system, RAND researchers investigate availability accessibility City.
Abstract 463 million people globally suffer from diabetes. The majority are deficient in insulin-producing pancreatic beta cells, although cells remain most with Unfortunately, many diabetes drugs exist, none is able to increase adult human cell numbers. Recently, small molecules that inhibit the kinase, DYRK1A, have been suggested induce replication vitro and vivo as assessed using proliferation markers, this enhanced by stimulate GLP1 receptor (GLP1R) on cells. DYRK1A inhibitors also...
More than 155,000 New Yorkers were trained in Mental Health First Aid (MHFA) between 2016 and 2020. The authors conducted a mixed-methods study that included web-based survey of past trainees series focus groups to assess the impact MHFA trainings needs for continued training future.
The ability to precisely control the activity of defined cell populations enables studies their physiological roles and may provide therapeutic applications. While prior have shown that magnetic activation ferritin-tagged ion channels allows cell-specific modulation cellular activity, large size constructs made use adeno-associated virus, AAV, vector choice for gene therapy, impractical. In addition, simple means generating fields sufficient strength been lacking. Toward these ends, we first...
The pancreas is a heavily innervated organ, but pancreatic innervation can be challenging to comprehensively assess using conventional histological methods. However, recent advances in whole-mount tissue clearing and 3D rendering techniques have allowed detailed reconstructions of innervation. Optical used enhance transparency reduce light scattering, thus eliminating the need section tissue. Here, we describe modified version optical protocol iDISCO+ (immunolabeling-enabled...
INTRODUCTION: Pancreatic islets are richly innervated by autonomic nerves which contribute to physiological regulation of islet hormone release and blood glucose. Published studies suggest obesity disrupts pancreatic innervation may metabolic dysfunction. However, these largely rely on 2D imaging experiments aimed at assessing the function have not been organ specific. Determining how high-fat diet (HFD) impacts nerve structure using 3D organ-specific neuromodulation provide new insights...
RAND researchers conducted three evidence reviews focused on sexual assault and harassment in adults. The first review focuses psychotherapy interventions for victims military settings, the second barriers facilitators to accessing care, third associations between mental health conditions: posttraumatic stress disorder, depression, substance use disorders.
ER stress is highly relevant in the context of diabetes, as inducers β cell death and dysfunction implicated disease - including proinflammatory cytokines glucolipotoxicity are known to impair function. Previous work has shown that prolactin (Prl) placental lactogen (PL), which bind same receptor (Prl-R), important for function proliferation, enhance survival against glucolipotoxicity. Here, we examine effect Prl/PL directly on associated unfolded protein response (UPR) cell. was induced...
This is a protocol for iDISCO Clearing and immunostaining of pancreata/intrapancreatic ganglia in mice.
Abstract Background: The pancreas is a highly heterogeneous organ, with regional anatomical, developmental and functional differences. endocrine densely innervated, neural signals play significant role in glucose regulation by modulating pancreatic hormone release. However, relatively little known about the anatomical relationships between islets nerves across whole pancreas. Since thin filamentous structures, such as nerves, are difficult to quantify trace over large volumes using section...