A5051683973- Liver Disease Diagnosis and Treatment
- Advanced Glycation End Products research
- Cholesterol and Lipid Metabolism
- Lipid metabolism and disorders
- Alcohol Consumption and Health Effects
- Pancreatic function and diabetes
- Biochemical effects in animals
- Endoplasmic Reticulum Stress and Disease
- Wastewater Treatment and Reuse
- Metabolism, Diabetes, and Cancer
- Folate and B Vitamins Research
- Analytical Chemistry and Sensors
- Peroxisome Proliferator-Activated Receptors
- Sphingolipid Metabolism and Signaling
- Neuropeptides and Animal Physiology
- Lanthanide and Transition Metal Complexes
- TiO2 Photocatalysis and Solar Cells
- Sulfur Compounds in Biology
- Diet, Metabolism, and Disease
- S100 Proteins and Annexins
- Phagocytosis and Immune Regulation
- Receptor Mechanisms and Signaling
- Luminescence and Fluorescent Materials
- Diabetes Treatment and Management
- Cannabis and Cannabinoid Research
Mayo Clinic in Arizona
2023-2025
Mayo Clinic
2024
WinnMed
2024
Indian Institute of Technology Mandi
2017-2022
Intrahepatic macrophages in nonalcoholic steatohepatitis (NASH) are heterogenous and include proinflammatory recruited monocyte derived macrophages. The receptor for advanced glycation end products (RAGE) is expressed on can be activated by damage associated molecular patterns (DAMPs) upregulated NASH, yet the role of macrophage-specific RAGE signaling NASH unclear. Therefore, we hypothesized that expressing mediate liver inflammation NASH. Compared to healthy controls, expression was...
Immune cell-driven inflammation is a key mediator of metabolic dysfunction-associated steatohepatitis (MASH) progression. We have previously demonstrated that pharmacological sphingosine 1-phosphate (S1P) receptor modulation ameliorates MASH and associated with attenuated accumulation intrahepatic macrophage T-cell subsets. Although S1P receptors are expressed on several immune cell types, given the prominent role monocyte-derived recruited macrophages in sterile MASH, we hypothesized...
Development of a highly photostable, renal clearable, and nontoxic new NIR probe (CyG) for precise quantification albumin in different biofluids liver targeted vivo visualization is demonstrated. CyG's inherent property to interact selectively with among biomolecules intracellular environment high degree sensitivity helps CyG imaging. In addition its long excitation/emission wavelengths (λex = 740 nm, λem 804 nm), which are much above the biological tissue opaque window (400-700 nm) ensuring...
Overconsumption of sucrose and other sugars has been associated with nonalcoholic fatty liver disease (NAFLD). Reports suggest hepatic de novo lipogenesis (DNL) as an important contributor to regulator carbohydrate-induced lipid accumulation in NAFLD. The mechanisms responsible for the increase DNL due overconsumption carbohydrate diet are less than clear; however, literatures high activate lipogenic transcription factor response element-binding protein (ChREBP), which further transcribes...
The glucagon-like peptide-1 receptor (GLP-1R) is a well-known target of therapeutics industries for the treatment various metabolic diseases like type 2 diabetes and obesity. structural–functional relationships small molecule agonists GLP-1R are yet to be understood. Therefore, an attempt was made on structurally known (Compound 1, Compound 2, A, B, (S)-8) study their interaction with extracellular domain GLP-1R. In this study, we explored dynamics, intrinsic stability, binding mechanisms...
Apolipoprotein H (APOH) downregulation can cause hepatic steatosis and gut microbiota dysbiosis. However, the mechanism by which APOH-regulated lipid metabolism contributes to metabolic dysfunction-associated steatotic liver disease (MASLD) remains undetermined. Herein, we aim explore regulatory effect of APOH, mediated through various pathways, on homeostasis MASLD pathogenesis. We analyzed serum marker levels, histopathology, cholesterol metabolism-related gene expression in global ApoH
Dysregulated hepatic de novo lipogenesis contributes to the pathogenesis of nonalcoholic fatty liver disease in both humans and rodents. Clinical evidence suggests have a positive correlation with serum lead (Pb 2+ ) levels. However, an exact mechanism Pb ‐induced progression is still unknown. Here, we show that exposure regulates Ch REBP ‐dependent lipogenesis. Presence ions within hepatocytes reduces transcript protein levels sorcin, cytosolic adaptor partner . Adenovirus‐mediated...
Nonalcoholic fatty liver disease (NAFLD) is an independent predictor of systemic insulin resistance and type 2 diabetes mellitus (T2DM). However, converse correlates between excess fat content β-cell function remain equivocal. Specifically, how the accumulation consequent to enhanced de novo lipogenesis (DNL) leads pancreatic failure eventually T2DM elusive. Here, we have identified that low-molecular-weight calcium-binding protein S100A6, or calcyclin, inhibits glucose-stimulated secretion...
We demonstrate a strategy for the recognition of As5+ in aqueous solution using red-emissive probe based on perylene-Cu2+ ensemble decorated with peripheral free carboxyl functionality. Single crystal analysis helped us to understand chemical structure probe. To best our knowledge, this is first arsenic detection which emits red region (λem = 600 nm). The exhibited mega-Stokes shift (>100 nm) high degree selectivity upon interaction As5+, indicated that present has potential be used as...
Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by reduced insulin sensitivity and dysfunction of β-cells. Although the increasing prevalence worldwide largely attributed to genetic predisposition or lifestyle factors (insufficient physical activity), caloric intake. Environmental factors, exposure xenobiotics heavy metals have also been reported be causative T2DM. At this juncture, we, through our work unveil plausible link between Pb2+ mellitus, delineated...
<p>Nonalcoholic fatty liver disease (NAFLD) is an independent predictor of systemic insulin resistance and type 2 diabetes mellitus (T2DM). However, converse correlates between excess fat content β-cell function remain equivocal. Specifically, how the accumulation consequent to enhanced <em>de novo</em> lipogenesis (DNL) leads pancreatic failure eventually T2DM elusive. Here we have identified low-molecular-weight calcium-binding protein S100A6 or calcyclin inhibits...
<p>Nonalcoholic fatty liver disease (NAFLD) is an independent predictor of systemic insulin resistance and type 2 diabetes mellitus (T2DM). However, converse correlates between excess fat content β-cell function remain equivocal. Specifically, how the accumulation consequent to enhanced <em>de novo</em> lipogenesis (DNL) leads pancreatic failure eventually T2DM elusive. Here we have identified low-molecular-weight calcium-binding protein S100A6 or calcyclin inhibits...