A5087122628- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Air Quality Monitoring and Forecasting
- Carcinogens and Genotoxicity Assessment
- Glutathione Transferases and Polymorphisms
- Noise Effects and Management
- Nanoparticles: synthesis and applications
- Genomics, phytochemicals, and oxidative stress
- Occupational and environmental lung diseases
- Microgrid Control and Optimization
- Occupational exposure and asthma
- Energy and Environment Impacts
- Heavy Metal Exposure and Toxicity
- Liver Disease Diagnosis and Treatment
- Inhalation and Respiratory Drug Delivery
- Islanding Detection in Power Systems
- Alcohol Consumption and Health Effects
- Chemical Safety and Risk Management
- Vascular Tumors and Angiosarcomas
- Electromagnetic Fields and Biological Effects
- Power Systems and Renewable Energy
- Nanotechnology research and applications
- Asthma and respiratory diseases
- Heart Rate Variability and Autonomic Control
- Climate Change Communication and Perception
National Taiwan University
2015-2024
National Taiwan University Hospital
2000-2021
Southern Taiwan University of Science and Technology
2012-2021
Kaohsiung Medical University
2020
Kaohsiung Medical University Chung-Ho Memorial Hospital
2020
Memorial Hospital
2016
Fu Jen Catholic University
2016
Taipei City Government
2014
National Taipei University
2011
Chia-Yi Christian Hospital
2010
To investigate changes in blood pressure, lipids, sugar and haematological markers of inflammation associated with long-term exposure to ambient air pollutants.We conducted secondary analyses data on pressure biochemistry from the Social Environment Biomarkers Aging Study Taiwan pollution Environmental Protection Administration 2000. Associations 1-year averaged criteria pollutants (particulate matter aerodynamic diameters <10 μm (PM(10)) <2.5 (PM(2.5)), ozone (O(3)), nitrogen dioxide...
The toxicological effects of zinc oxide nanoparticles (ZnO-NPs) are attracting increasing concern as the field nanotechnology progresses. Although literature suggests that toxicity ZnO-NPs may be related to their dissolution, mechanism for ZnO-NP perturbation cytosolic concentration ([Zn2+]c) homeostasis remains obscure. Using FluoZin-3 and RhodZin-3, this study investigated changes in both [Zn2+]c mitochondrial free Zn2+ ([Zn2+]m) under conditions treatment vivo vitro. In human leukemia...
Journal Article Ethnic differences in the prevalence of homozygous deleted genotype glutathione S-transferase theta Get access Heather H. Nelson, Nelson 1Department Cancer Biology. Harvard School Public Health665 Huntington Avenue, Boston, MA 02115 Search for other works by this author on: Oxford Academic PubMed Google Scholar John K. Wiencke, Wiencke 2Laboratory Molecular Epidemiology. Department Epidemiology and Biostatistics, Medicine, University California-San FranciscoSan Francisco, CA...
BackgroundLittle is known about the global magnitude of mesothelioma. In particular, many developing countries, including some with extensive historical use asbestos, do not report mesothelioma.ObjectivesWe estimated mesothelioma accounting for reported and unreported cases.MethodsFor all countries available data on frequency asbestos (n = 56), we calculated 15-year cumulative number mesotheliomas during 1994–2008 from fewer years assessed its relationship levels 1920–1970. We used this to...
Objective: To investigate changes in blood pressure, lipids, and sugar associated with exposure to ambient air pollution. Methods: We conducted secondary analyses of pressure biochemistry markers from Taiwanese Survey on Prevalence Hyperglycemia, Hyperlipidemia, Hypertension pollution monitoring data 2002 by applying generalized additive models. Results: observed increased particulate matter aerodynamic diameters <10 μm was elevated systolic (an interquartile range, 34 μg/m3, for 0.47 mmHg;...
To examine the correlations between long working hours, physical activity, and burnout.A cross-sectional survey was administered to 1560 full-time employees, who underwent periodic health examinations in year 2013. The subjects were divided into upper, middle, lower tertiles according Copenhagen Burnout Inventory (CBI) score.The comparison of high- low-burnout groups revealed that hours significantly correlated with burnout a dose-dependent manner. Long more associated among individuals...
Exposure to zinc oxide (ZnO) metal fumes is linked adverse human health effects; however, the hazards of ZnO nanoparticles (ZnONPs) remain unclear. To determine pulmonary exposure occupationally relevant ZnONPs cause cardiopulmonary injury, Sprague-Dawley rats were exposed via intratracheal (IT) instillation and inhalation. The relationship between intrapulmonary levels oxidative-inflammatory responses 72 h after ZnONP was determined in bronchoalveolar lavage fluid (BALF). Instilled altered...
The total surface area is known to be an effective exposure metric for predicting the lung toxicity of low solubility nanoparticles (NPs). However, if NPs are dissolved quickly enough in lungs, mass may correlated with toxicity. Recent studies have found that zinc oxide (ZnO) was caused by release ions. Thus, we hypothesized could used as ZnO NPs. Healthy Sprague-Dawley rats were exposed a low, moderate, or high dose 35 and 250 nm particles filtered air. Bronchoalveolar lavage fluid...
Background Particulate matter (PM) has been associated with increased pulmonary and cardiovascular mortality morbidity. Additionally, PM is known to exacerbate asthma. However, whether ambient exposure contributes the onset of asthma, especially in non-atopic children adults, less conclusive. The current study aimed evaluate effects size-fractioned on lung immune responses healthy BALB/c mice. Methods principal findings We collected PM10, PM2.5, PM1 PM0.1 samples from October 2012 August...
Evidence on the association between long-term exposure to air pollution and cardiovascular mortality is limited in Asian populations. We conducted a cohort study fine particulate matter (PM2.5) using 43,227 individuals civil servants health service Taiwan. Each participant was assigned an level of based their district residence data collected by Taiwan Environmental Protection Agency with modeling geographic information systems. The participants were followed up from 1989 2008 vital status...
Effects of air pollution on neurotoxicity and behavioral alterations have been reported. The objective this study was to investigate the pathophysiology caused by particulate matter (PM) in brain. We examined effects traffic-related with an aerodynamic diameter < 1 μm (PM1), high-efficiency (HEPA)-filtered air, clean brain structure, changes, brainwaves, bioreactivity (cortex, cerebellum, hippocampus), olfactory bulb, serum after 3 6 months whole-body exposure 6-month-old Sprague Dawley...
Although numerous epidemiological studies revealed an association between ambient fine particulate matter (PM 2.5 ) exposure and Alzheimer’s disease (AD), the PM -induced neuron toxicity associated mechanisms were not fully elucidated. The present study assessed brain in 6-month-old female triple-transgenic AD (3xTg-AD) mice following subchronic to via inhalation system. treated whole-bodily continuously exposed real-world for 3 months, while control inhaled filtered air. Changes cognitive...