A5028697215- Scientific Research and Philosophical Inquiry
- Microfluidic and Bio-sensing Technologies
- Neuroscience and Neural Engineering
- Orbital Angular Momentum in Optics
- 3D Printing in Biomedical Research
- Chemical Synthesis and Analysis
- Estrogen and related hormone effects
- Hormonal and reproductive studies
- Cell Adhesion Molecules Research
- Philosophy, Science, and History
- Coccidia and coccidiosis research
- Cell Image Analysis Techniques
- Neuroscience and Neuropharmacology Research
- Veterinary medicine and infectious diseases
- Analytical Chemistry and Sensors
- Bone health and treatments
- Supramolecular Chemistry and Complexes
- Receptor Mechanisms and Signaling
- Inflammatory mediators and NSAID effects
- Protein Kinase Regulation and GTPase Signaling
- Pharmacogenetics and Drug Metabolism
- Viral Infectious Diseases and Gene Expression in Insects
- Congenital heart defects research
- Prostate Cancer Treatment and Research
- Cellular Mechanics and Interactions
Miltenyi Biotec (Germany)
2018-2024
United States Military Academy
2002-2023
University of Münster
2017-2021
Biogen (United States)
2021
Blueprint Medicines (United States)
2021
École Polytechnique Fédérale de Lausanne
2010-2015
Angelina College
2010
Ulrich Medical (Germany)
2009
Elisa (Finland)
2009
Scripps Research Institute
1997-2000
The synthesis and characterization of a system for the study molecular recognition phenomena are described. involves tetraurea molecule that is capable assembly into various associated states through hydrogen bonding. In organic solvents, dynamic transition between low-ordered (aggregate) state highly ordered dimeric can be induced by introduction smaller molecules appropriate size shape. These molecules, such as benzene, adamantanes, ferrocenes, act guests occupy pseudospherical capsule...
3(S)-(6-methoxypyridin-3-yl)-3-[2-oxo-3-[3-(5,6,7,8-tetrahydro-[1,8]-naphthyridin-2-yl)propyl]imidazolidin-1-yl]propionic acid 6 was identified as a potent and selective antagonist of the alpha(v)beta(3) receptor. This compound has an excellent in vitro profile (IC(50) = 0.08 nM), significant unbound fraction human plasma (12%), good pharmacokinetics rat, dog, rhesus monkey. On basis efficacy shown three vivo models bone turnover, selected for clinical development. To support ongoing...
Experimental details are given for the preparation of "softballs", large self-complementary molecules capable assembly into pseudo-spherical capsules. Evidence is presented their existence as hydrogen bonded dimers in organic solvents, and binding affinities reversible encapsulation smaller suitable size shape given. Studies at various temperatures result calculated enthalpies entropies that positive; accordingly, process entropy driven. It proposed hosts resting states contain two solvent...
Selective androgen receptor modulators (SARMs) are (AR) ligands that induce anabolism while having reduced effects in reproductive tissues. In various experimental contexts SARMs fully activate, partially or even antagonize the AR, but how these complex activities translate into tissue selectivity is not known. Here, we probed function using >1000 synthetic AR ligands. These compounds produced a spectrum of each assay ranging from 0 to 100% maximal response. By testing different classes...
Herein, we describe the development of a functionally selective liver X receptor β (LXRβ) agonist series optimized for Emax selectivity, solubility, and physical properties to allow efficacy safety studies in vivo. Compound 9 showed central pharmacodynamic effects rodent models, evidenced by statistically significant increases apolipoprotein E (apoE) ATP-binding cassette transporter levels brain, along with greatly improved peripheral lipid profile when compared those full dual agonists....
Multiple Sclerosis is a chronic autoimmune neurodegenerative disorder of the central nervous system (CNS) that characterized by inflammation, demyelination, and axonal injury leading to permeant disability. In early stage MS, inflammation primary driver disease progression. There remains an unmet need develop high efficacy therapies with superior safety profiles prevent processes Herein, we describe discovery BIIB091, structurally distinct orthosteric ATP competitive, reversible inhibitor...
We present a novel study on label-free recognition and distinction of drug resistant breast cancer cells (MCF-7 DOX) from their parental WT) via impedimetric measurements. Drug exhibited significant differences in dielectric properties compared to wild-type cells, exerting much higher extracellular resistance (Rextra ). Immunostaining revealed that MCF-7 DOX gained denser F-actin network upon acquiring indicating remodeling actin cytoskeleton is probably the reason behind Rextra , providing...
Understanding embryonic development requires the characterization of forces and mechanical features that shape cells tissues within organism. In addition, experimental application on altering cell organelle allows determining role such play in morphogenesis. Here, we present a holographic optical tweezers-based new microscopic platform for vivo applications context developing vertebrate embryo unlike currently used setups simultaneous trapping multiple objects rapid comparisons viscoelastic...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConvergent synthesis of polyether ionophore antibiotics: the spiroketal and tricyclic glycal segments monensinRobert E. Ireland, Joseph D. Armstrong III, Jacques Lebreton, Robert S. Meissner, Mark A. RizzacasaCite this: J. Am. Chem. Soc. 1993, 115, 16, 7152–7165Publication Date (Print):August 1, 1993Publication History Published online1 May 2002Published inissue 1 August...
Androgen replacement therapy is a promising strategy for the treatment of frailty; however, androgens pose risks unwanted effects including virilization and hypertrophy reproductive organs. Selective Receptor Modulators (SARMs) retain anabolic properties in bone muscle while having reduced other tissues. We describe two structurally similar 4-aza-steroidal androgen receptor (AR) ligands, Cl-4AS-1, full agonist, TFM-4AS-1, which SARM. TFM-4AS-1 potent AR ligand (IC(50), 38 nm) that partially...
We present a novel perfusion-based microfluidic platform for label-free drug toxicity screening which can single out non-lethal morphological changes from cellular death using electrical impedance spectroscopy. Minor such as cell-cell contacts and major cell injury were identified via phase angle analysis follow-up of magnitude at different frequencies. Having exposed HepG2/C3A cells to acetaminophen (AP), we showed that continuous perfusion caused time concentration-dependent decrease....
Abstract BACKGROUND: Non-small cell lung cancer (NSCLC) represents 80% of cancers, the second leading cause deaths globally. Mutations in kinase domain epidermal growth factor receptor (EGFR) are genomic drivers a molecular sub-type NSCLC that is sensitive to tyrosine inhibitors (TKIs). Third-generation, irreversible TKIs, such as osimertinib and lazertinib, have become standard care now widely used first-line therapy EGFR-driven metastatic NSCLC. However, resistance invariably arises during...
Abstract We report an alternative technique to perform a direct and local measurement of electrical resistivities in layered retinal tissue. Information on resistivity changes along the depth retina is important for modelling stimulation by prostheses. Existing techniques resistivity-depth profiling have drawbacks complicated experimental setup, less localised probing and/or lower stability measurements. employed flexible microprobe measure with bipolar impedance spectroscopy at various...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConvenient method for the titration of amide base solutionsRobert E. Ireland and Robert S. MeissnerCite this: J. Org. Chem. 1991, 56, 14, 4566–4568Publication Date (Print):July 1, 1991Publication History Published online1 May 2002Published inissue 1 July 1991https://pubs.acs.org/doi/10.1021/jo00014a050https://doi.org/10.1021/jo00014a050research-articleACS PublicationsRequest reuse permissionsArticle Views5405Altmetric-Citations26LEARN ABOUT THESE...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConvergent synthesis of polyether ionophore antibiotics: protective manipulation and monensin ARobert E. Ireland, Robert S. Meissner, Mark A. RizzacasaCite this: J. Am. Chem. Soc. 1993, 115, 16, 7166–7172Publication Date (Print):August 1, 1993Publication History Published online1 May 2002Published inissue 1 August 1993https://pubs.acs.org/doi/10.1021/ja00069a014https://doi.org/10.1021/ja00069a014research-articleACS PublicationsRequest reuse...