A5055534423- Virus-based gene therapy research
- CRISPR and Genetic Engineering
- CAR-T cell therapy research
- Brucella: diagnosis, epidemiology, treatment
- Birth, Development, and Health
- Hemoglobinopathies and Related Disorders
- Hematopoietic Stem Cell Transplantation
- Iron Metabolism and Disorders
- RNA Interference and Gene Delivery
- Pregnancy and preeclampsia studies
- Prenatal Screening and Diagnostics
- Biochemical Analysis and Sensing Techniques
- Viral Infectious Diseases and Gene Expression in Insects
- Mosquito-borne diseases and control
- Immune Cell Function and Interaction
- Viral Infections and Vectors
- Biomedical Ethics and Regulation
- Herpesvirus Infections and Treatments
- Phytochemistry and Biological Activities
- Cell Image Analysis Techniques
- Zoonotic diseases and public health
- PI3K/AKT/mTOR signaling in cancer
- Regulation of Appetite and Obesity
- Essential Oils and Antimicrobial Activity
- Dermatological diseases and infestations
National and Kapodistrian University of Athens
2014-2025
Miltenyi Biotec (Germany)
2019-2024
Goethe University Frankfurt
2023
Berliner Verkehrsbetriebe (Germany)
2023
Biomedical Research Foundation of the Academy of Athens
2010-2022
Athens Medical Center
2020
Rutgers, The State University of New Jersey
2016
Eugenides Hospital
2016
Aristotle University of Thessaloniki
1996-2015
Academy of Athens
2006-2014
Three Origanum essential oils, vulgare ssp. hirtum, dictamnus, and a commercially available oil, were analyzed by gas chromatography−mass spectrometry (GC−MS) showed high content of carvacrol, thymol, γ-terpinene, p-cymene representing 73.7%, 92.8%, 87.78% the total respectively. The three oils exhibited levels antimicrobial activity against eight strains Gram-positive Gram-negative bacteria. Among major components carvacrol thymol highest activity, while their biosynthetic precursors...
Salvia fructicosa essential oil analyzed by gas chromatography/mass spectrometry showed high contents of 1,8-cineole, α- and β-thujone, camphor, representing 47.48%, 11.93%, 9.04% the total oil, respectively. The its isolated components thujone 1,8-cineole exhibited antimicrobial activity against eight bacterial strains, while camphor was almost inactive all bacteria tested. bactericidal at 1/4000 dilution, dilutions up to 1/10000 caused considerable decrease in growth rates. S. three main...
Between May and September 2011, twenty cases of Plasmodium vivax infection were reported in Greek citizens without travel history. The vast majority those confined to a delimited agricultural area Evrotas, Lakonia. Conditions favouring locally acquired transmission malaria, including the presence competent vectors migrants from endemic countries exist Greece, underscoring need for development an integrated preparedness response plan malaria prevention.
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Background: Pathogenic variants within the gene encoding transforming growth factor β (TGF-β) are responsible for Loeys-Dietz syndrome (LDS), a heritable thoracic aortic disease sharing clinical features with Marfan syndrome, including craniofacial and skeletal abnormalities as well root aneurysms dissections. In contrast to patients, who rarely develop or dissections beyond root, LDS patients frequently exhibit vessel in locations other than root. Here, we report case of 61-year-old patient...
Background and Purpose Asthma manifests as a heterogeneous syndrome characterized by airway obstruction, inflammation hyperresponsiveness (AHR). Although the molecular mechanisms remain unclear, activation of specific PI3K isoforms mediate AHR. We aimed to determine whether inhibition PI3Kδ evokes dilation airways elucidate potential mechanisms. Experimental Approach Human precision cut lung slices from non‐asthma donors primary human smooth muscle (HASM) cells both asthma were utilized....
Between 16 July and 21 August 2011, 31 cases of West Nile neuroinvasive disease were reported from four regions in Greece. Of these, 17 occurred districts that had not been affected 2010. The reoccurrence human two consecutive years (following the large 2010 outbreak) spread virus new areas suggest is established Greece, its transmission may continue to occur future.
Amid an increasing number of reports in the literature concerning epithelial barrier enhancement by various nutrient compounds, there has never been a study performing side-by-side comparisons these agents single model. We compare five compounds (previously reported models to enhance function) regarding their ability increase transepithelial electrical resistance (Rt) and decrease mannitol permeability (Jm) across LLC-PK1 renal cell layers. The effects nutrients on abundance tight junctional...
To address how low titer, variable expression, and gene silencing affect therapy vectors for hemoglobinopathies, in a previous study we successfully used the HPFH (hereditary persistence of fetal hemoglobin)-2 enhancer series oncoretroviral vectors. On basis these data, generated novel insulated self-inactivating (SIN) lentiviral vector, termed GGHI, carrying (A)γ-globin with -117 point mutation HPFH-2 exhibiting pancellular pattern expression MEL-585 clones. assess eventual clinical...
Purpose Access to culture is a fundamental right of people with disabilities and significant aspect in the development accessible tourism. A visit monument provides an authentic experience which cannot be substituted by any representation. However, interventions improve accessibility should made carefully, so as not alter monument’s character, or damage it visually structurally. The paper aims discuss these issues. Design/methodology/approach theoretical approach model was defined...
Gene therapy utilizing lentiviral-vectors (LVs) is postulated as a dynamic therapeutic alternative for monogenic diseases. However, retroviral gene transfer may cause insertional mutagenesis. Although, such risks had been originally estimated extremely low, several reports of leukemias or clonal dominance, have led to re-evaluation the mechanisms operating in Therefore, unraveling mechanism integration mandatory toward safer applications. In present study, we undertook an experimental...
Prematurity has been linked with endothelial dysfunction in later life. The purpose of this study was to evaluate the association between plasma irisin, an adipomyokine reported protect functional integrity vascular endothelium, and circulating microparticles (EMPs) progenitor cells (EPCs), consisting early biomarkers dysfunction, preterm-born children. We studied 131 prepubertal children; 61 preterm 70 born at term (controls). Plasma irisin determined by ELISA. Circulating CD62E(+),...