A5023966983- Cellular Mechanics and Interactions
- Developmental Biology and Gene Regulation
- Hippo pathway signaling and YAP/TAZ
- Genetics, Bioinformatics, and Biomedical Research
- Microtubule and mitosis dynamics
- Genetics, Aging, and Longevity in Model Organisms
- Zebrafish Biomedical Research Applications
- Neurobiology and Insect Physiology Research
- Biomimetic flight and propulsion mechanisms
- Spaceflight effects on biology
- Physiological and biochemical adaptations
- Experimental Learning in Engineering
- RNA Research and Splicing
- Circadian rhythm and melatonin
- Biocrusts and Microbial Ecology
- Innovative Teaching and Learning Methods
- Cell Image Analysis Techniques
- Wikis in Education and Collaboration
- Science Education and Pedagogy
- Visual perception and processing mechanisms
- Blood properties and coagulation
- Bioinformatics and Genomic Networks
- Gene Regulatory Network Analysis
- Innovative Teaching Methods
- Visual and Cognitive Learning Processes
University of Zurich
2010-2024
Life Science Zurich
2015
Wageningen University & Research
2003-2006
ETH Zurich
2006
MRC Laboratory of Molecular Biology
2005
State Key Laboratory of Molecular Biology
2005
Morphogenesis emerges from complex multiscale interactions between genetic and mechanical processes. To understand these processes, the evolution of cell shape, proliferation gene expression must be quantified. This quantification is usually performed either in full 3D, which computationally expensive technically challenging, or on 2D planar projections, introduces geometrical artifacts highly curved organs. Here we present MorphoGraphX (www.MorphoGraphX.org), a software that bridges this...
Apical cell surfaces in metazoan epithelia, such as the wing disc of Drosophila, resemble polygons with different numbers neighboring cells. The distribution these polygon has been shown to be conserved. Revealing mechanisms that lead this topology might yield insights into how structural integrity epithelial tissues is maintained. It previously proposed division alone, or combination rearrangements, sufficient explain observed topology. Here, we extend work by including an analysis...
The regulation of organ size constitutes a major unsolved question in developmental biology. wing imaginal disc Drosophila serves as widely used model system to study this question. Several mechanisms have been proposed an impact on final size, but they are either contradicted by experimental data or cannot explain number key observations and may thus be missing crucial elements. We modeled regulatory network that integrates the experimentally confirmed molecular interactions underlying...
Control of cessation growth in developing organs has recently been proposed to be influenced by mechanical forces acting on the tissue due its growth. In particular, it was that stretching leads an increase cell proliferation. Using model system Drosophila wing imaginal disc, we directly stretch finding a significant proliferation, thus confirming this hypothesis. addition, characterize over entire period disc correlation between apical area and proliferation rate. PACS numbers: 87.19.lx,...
Driven by the massive datasets that are generated “omics” research, molecular life sciences entering a new phase. This phase is characterised shift in focus from individual genes and their products to networks whole systems [1,2,3]. For thorough analysis of behaviour underlying principles, quantitative tools often necessary. Numerical simulations can, for example, be used explore network when values different parameters varied, and, turn, mathematical can help understand particular...
Microfluidics enables the interference free observation of sensitive developmental processes in<italic>C. elegans</italic>.
In developmental biology, the sequence of gene induction and pattern formation is best studied over time as an organism develops. However, in model system Drosophila larvae this oftentimes proves difficult due to limitations imaging capabilities. Using larval wing imaginal disc, we show that both overall growth, well creation patterns such distinction between anterior(A) posterior(P) compartments dorsal(D) ventral(V) can be directly by disc it develops inside a larva. Imaged develop...
Non-intermingling, adjacent populations of cells define compartment boundaries; such boundaries are often essential for the positioning and maintenance tissue-organizers during growth. In developing wing primordium Drosophila melanogaster, signaling by secreted protein Hedgehog (Hh) is required boundary maintenance. However, precise mechanism Hh input remains poorly understood. Here, we combine experimental observations perturbed with computer simulations cellular behavior, connect physical...
The caudal fins of adult zebrafish are supported by multiple bony rays that laterally interconnected soft interray tissue. Little is known about the fin's mechanical properties influence bending in response to hydrodynamic forces during swimming. Here, we developed an experimental setup measure elastic in-vivo applying micro-Newton obtain stiffness and a tensional modulus. We detected overall moments 1.5 - 4x10−9 Nm2 along proximal-distal axis appendage showing non-monotonous pattern not due...
Germ cell apoptosis in Caenorhabditis elegans hermaphrodites is a physiological process eliminating around 60% of all cells meiotic prophase to maintain tissue homeostasis. In contrast programmed death the C . soma, selection germ undergoing stochastic. By live-tracking individual at pachytene stage, we found that smaller than their neighbors are selectively eliminated through before differentiating into oocytes. Thus, size strong predictor death. The RAS/MAPK and ECT/RHO/ROCK pathways...
Understanding how extrinsic factors modulate genetically encoded information to produce a specific phenotype is of prime scientific interest. In particular, the feedback mechanism between abiotic forces and locomotory organs during morphogenesis achieve efficient movement highly relevant example such modulation. The study this developmental process can provide unique insights on transduction cues at interface physics biology. Here, we take advantage natural ability adult zebrafish regenerate...
Abstract Germ cell apoptosis in C. elegans hermaphrodites is a physiological process eliminating around 60% of all cells meiotic prophase to maintain tissue homeostasis. In contrast programmed death the soma, selection germ undergoing stochastic. By live-tracking individual at pachytene stage, we found that smaller than their neighbors are selectively eliminated through before differentiating into oocytes. Thus, size strong predictor death. The RAS/MAPK and ECT/RHO/ROCK pathways together...
The regulation of organ size constitutes a major unsolved question in developmental biology.The wing imaginal disc Drosophila serves as widely used model system to study this question.Several mechanisms have been proposed an impact on final size, but they are either contradicted by experimental data or cannot explain number key observations and may thus be missing crucial elements.We modeled regulatory network that integrates the experimentally confirmed molecular interactions underlying...
Abstract The building of models to explain data and make predictions constitutes an important goal in molecular biology research. To give students the opportunity practice such model building, two digital cases had previously been developed which are guided build a step by step. In this article, development initial evaluation third case is described. It concerns selection bristles during Drosophila development. mimic real research situation more realistic way, given much freedom while their...