A5081288451- Drug-Induced Adverse Reactions
- Contact Dermatitis and Allergies
- Pharmaceutical studies and practices
- Biochemical Analysis and Sensing Techniques
- Regulation of Appetite and Obesity
- Dermatology and Skin Diseases
- Autoimmune Bullous Skin Diseases
- Liver Disease Diagnosis and Treatment
- Allergic Rhinitis and Sensitization
- melanin and skin pigmentation
- Urticaria and Related Conditions
- Asthma and respiratory diseases
- Nanoparticles: synthesis and applications
- Liver physiology and pathology
- Microplastics and Plastic Pollution
- Pancreatic and Hepatic Oncology Research
- Pharmacovigilance and Adverse Drug Reactions
- Pregnancy and Medication Impact
- Ureteral procedures and complications
- Urologic and reproductive health conditions
- Urinary Bladder and Prostate Research
- Healthcare and Environmental Waste Management
- Trace Elements in Health
- Pharmacological Receptor Mechanisms and Effects
- Nail Diseases and Treatments
University of Zagreb
2016-2025
University Hospital Dubrava
2020-2021
The development of efficient drug formulations for Parkinson's disease (PD) treatment is challenged by achieving pharmacokinetic profiles, reduced side effects, and better permeability through the blood–brain barrier (BBB). As nanoparticles may facilitate delivery drugs in brain due to their high-loading capacity ability cross biological barriers, we designed two different types selenium (SeNPs) that increase transport across BBB act as antioxidants at site action. SeNPs were functionalized...
Prevalence of potential drug-drug interactions (pDDIs) in adult patients with severe asthma on biological therapy and their clinical significance have not been fully addressed, thus the aim this study was to investigate them. In retrospective observational study, who were diagnosed whom prescribed between September 2015 December 2020, enrolled. The conducted at Department Allergic Obstructive Pulmonary Diseases, Clinic for Lung Diseases Jordanovac, Clinical Hospital Center Zagreb. Data...
Many personal care products on the market contain endocrine disrupting chemicals, including parabens. Parabens are well known chemical additives used as preservatives. They have been found in mammary glands and breast cancer tissues. At same time, general public is increasingly exposed to plastic micro- nanoparticles generated during production waste disposal. Exposure cocktails a realistic scenario of high health interest, which many types compounds such these two may exhibit synergistic or...
Background: olive pomace extract (OPE) is a rich source of health promoting polyphenols (hydroxytyrosol (HTS) and tyrosol (TS)) can be used as nutraceutical ingredient dietary supplements functional foods. Its adequate bioavailability prerequisite for excreting biological activity significantly specifically affected by different food matrices. Methods: in order to investigate effects on polyphenol bioaccessibility, OPE was co-digested with foods according internationally harmonized vitro...
25-Hydroxyvitamin D (25-OHD) may have a prognostic value in colorectal cancer (CRC) patients. However, as 25-OHD concentration is strongly impacted by surgery, it uncertain what the most reliable time-point for assessment, pre- or post-operative. Therefore, we examined 515 CRC patients (AJCC I-III) who underwent surgery. Blood samples were collected either pre-operatively (n = 286; median 1 day before surgery) post-operatively 229; 8 days). Serum was determined liquid chromatography–tandem...
Nanoformulations decrease systemic toxicity effects of antitumor agents.
To evaluate the impact of pharmacotherapeutic education on 30-day post-discharge medication adherence and adverse outcomes in patients with type 2 diabetes mellitus (T2DM).The prospective, randomized, single-center study was conducted at Medical Department University Hospital Dubrava, Zagreb, between April June 2018. One hundred thirty adult T2DM who were discharged to community randomly assigned either intervention or control group. Both groups during hospital stay received usual education....
Antisense peptide technology is a valuable tool for deriving new biologically active molecules and performing peptide–receptor modulation. It based on the fact that peptides specified by complementary (antisense) nucleotide sequences often bind to each other with higher specificity efficacy. We tested validity of this concept example human erythropoietin, well-characterized pharmacologically relevant hematopoietic growth factor. The purpose work was present test simple efficient three-step...
Abstract Recent studies have established a concept of tumour necrosis factor‐α (TNF‐α)/Fas signalling crosstalk, highlighting TNF‐α as critical cytokine in sensitizing hepatocytes to death induced by Fas activation. However, the exact inflammatory response, besides TNF‐α, many other mediators, that might modulate apoptotic response differentially, are released. To resolve issue, we studied effects lipopolysaccharide (LPS), one crucial inductors inflammation liver, on outcome. We show...
The available treatments for cholestatic liver fibrosis are limited, and the disease often progresses to cirrhosis. Tamoxifen is a selective modulator of estrogen receptors, commonly used in breast cancer therapy. A recent vitro study showed that tamoxifen deactivates hepatic stellate cells, suggesting its potential as an antifibrotic therapeutic, but effects vivo remain poorly investigated. In present study, we show protects against induced by diet supplemented with 0.025%...
The genetic code defines nucleotide patterns that for individual amino acids and their complementary, i.e., antisense, pairs. Peptides specified by the complementary mRNAs often bind to each other with a higher specificity efficacy. Applications of this property in biomedicine are related modulation peptide hormone biological function, selective immunomodulation, modeling discontinuous linear epitopes, mimotopes, paratopes antibody mimetics, vaccine development, peptidomimetic drug design....
The purpose of this paper was to outline the development short peptide targeting human prostate specific antigen (hPSA), and evaluate its effectiveness in staining PSA cancer tissue. hPSA by means antisense AVRDKVG designed according a three-step method involving: 1. selection molecular target (hPSA epitope), 2. modeling an (paratope) based on epitope sequence, 3. spectroscopic evaluation sense–antisense binding. We then modified standard immunohistochemical practice using biotinylated...
Proteins and peptides in mammals are based exclusively on L-amino acids. Recent investigations show that D-amino acids exhibit physiological effects vivo, despite of their very small quantities. We have investigated the hepatoprotective Land D-enantiomers alpha-melanocortin peptide (alpha-MSH). The results showed peptide-enantiomerism is related to protective melanocortin vivo. L-alpha-MSH exhibited potent effect experimental model acetaminophen induced hepatotoxicity male CBA mice, while...
Melanocortins, i.e., melanocyte stimulating hormones (MSH) are peptides with strong antiinflammatory effects. The most investigated aspects of γ2-MSH related to cardiovascular effects and natriuresis, limited research available about its anti-inflammatory cytoprotective aims this study were: 1) examine the derivative [D-Trp8]-γ2-MSH on acetaminophen model liver damage in CBA mice; 2) evaluate modulation hepatoprotection by melanocortin subtypes 3 4 receptor antagonists SHU 9119 HS 024; 3)...