A5059880185- Cytokine Signaling Pathways and Interactions
- Bone Metabolism and Diseases
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Cell death mechanisms and regulation
- Organ Transplantation Techniques and Outcomes
- Chemokine receptors and signaling
- Cell Adhesion Molecules Research
- Biomarkers in Disease Mechanisms
- Hepatitis B Virus Studies
- Vitamin D Research Studies
- Rheumatoid Arthritis Research and Therapies
- Alcohol Consumption and Health Effects
- TGF-β signaling in diseases
- Breast Lesions and Carcinomas
- Vitamin C and Antioxidants Research
- MRI in cancer diagnosis
- Human Health and Disease
- Advanced MRI Techniques and Applications
- Skin Protection and Aging
- Immune cells in cancer
- Hormonal Regulation and Hypertension
- Bone health and treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Hypoxia, and Metabolism
University of Mostar
2021-2022
University Clinical Hospital Mostar
2018-2021
University of Zagreb
2015-2020
The peripheral blood (PB) monocyte pool contains osteoclast progenitors (OCPs), which contribute to osteoresorption in inflammatory arthritides and are influenced by the cytokine chemokine milieu. We aimed define importance of signals for migration activation OCPs rheumatoid arthritis (RA) psoriatic (PsA). PB and, when applicable, synovial fluid (SF) samples were collected from 129 patients with RA, 53 PsA, 110 control parallel clinical parameters disease activity, autoantibody levels,...
25-Hydroxyvitamin D (25-OHD) may have a prognostic value in colorectal cancer (CRC) patients. However, as 25-OHD concentration is strongly impacted by surgery, it uncertain what the most reliable time-point for assessment, pre- or post-operative. Therefore, we examined 515 CRC patients (AJCC I-III) who underwent surgery. Blood samples were collected either pre-operatively (n = 286; median 1 day before surgery) post-operatively 229; 8 days). Serum was determined liquid chromatography–tandem...
Abstract Recent studies have established a concept of tumour necrosis factor‐α (TNF‐α)/Fas signalling crosstalk, highlighting TNF‐α as critical cytokine in sensitizing hepatocytes to death induced by Fas activation. However, the exact inflammatory response, besides TNF‐α, many other mediators, that might modulate apoptotic response differentially, are released. To resolve issue, we studied effects lipopolysaccharide (LPS), one crucial inductors inflammation liver, on outcome. We show...
Detailed characterization of medullary and extramedullary reservoirs osteoclast progenitors (OCPs) is required to understand the pathophysiology increased periarticular systemic bone resorption in arthritis. In this study, we focused on identifying OCP population specifically induced by arthritis role circulatory OCPs inflammatory loss. addition, determined relevant chemokine axis responsible for their migration, targeted attraction signal reduce murine collagen-induced (CIA). were expanded...
Abstract While increased serum concentrations of CXCL9/10 are associated with acute cellular rejection (ACR) occurrence, the association between single nucleotide polymorphisms (SNPs) and ACR after liver transplantation (LT) remains unknown. In present case-control study, CXCL9 (rs10336) CXCL10 (rs3921) were determined by polymerase chain reaction in 215 transplant recipients. was defined as biopsy proven within 6 months LT. As selected SNPs 3’-UTR region, their possible protein synthesis...
Rheumatoid arthritis (RA) is an inflammatory joint disease that eventually leads to permanent bone and cartilage destruction. Fas has already been established as the regulator of inflammation in RA, but its role formation under arthritic conditions not completely defined. The aim this study was assess effect inactivation on damage during murine antigen-induced arthritis. Subchondral wild-type (WT) Fas-knockout (Fas-/-) mice evaluated by histomorphometry microcomputerized tomography....
Vitamin D has been a focus of attention in liver cancer due to its direct and indirect antineoplastic effects. This review critically evaluates data from recently published basic clinical studies investigating the role vitamin cancer. Basic indicate that plays an important development by suppressing activity hepatic stellate cells Kupffer cells. Furthermore, anti-proliferative, anti-angiogenic, proapoptotic, prodifferentiative effect on Recent investigation suggested several interesting...
AimTo investigate the association of FasL gene polymorphism (rs763110) with rheumatoid arthritis occurrence, disease activity, and tumor necrosis factor-α (TNF-α) plasma concentration in Croatian patients, to conduct an updated meta-analysis. MethodsThis cross-sectional study enrolled 81 patients 94 control patients.After assessment Disease Activity Score (DAS)-28, blood was taken for analysis.DNA isolated from whole determine by polymerase chain reaction.Protein levels TNF-α were determined...
Although MRI is the most efficient method of detecting breast cancer, its standard protocol time-consuming and expensive. The objective this study was to compare diagnostic accuracy modified innovative abbreviated (AMRP) magnetic resonance (SMRP) when cancer.The research involved 477 patients referred for due suspected lesions. They were randomly assigned AMRP group (N = 232) or SMRP 245). comprised one native (contrast-free) four post-contrast dynamic sequences T1-weighted volume imaging...
Alcoholic liver cirrhosis (ALC) is the most common indication for transplantation (LT) in Croatia and presents a risk factor development of hepatocellular carcinoma (HCC). However, genetic susceptibility has not yet been systematically studied. We aimed to investigate contribution polymorphisms PNPLA3 rs738409, EGF rs4444903, TM6SF2 rs58542926, MTHFR rs1801133, previously identified other populations and, additionally, Notch-related (NOTCH1 rs3124591, NOTCH3 rs1043996 rs1044116, NOTCH4...
Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
<h3>Background</h3> Osteitis, replacement of bone marrow adipocytes with inflammatory cells, is an early sign inflammation in rheumatoid arthritis (RA), seen as edema by magnetic resonance imaging. Osteoclast progenitors (OCPs), normally present within circulating monocytes, are presumed to be increasingly attracted inflamed joints RA, where their enhanced activation and differentiation leads excessive osteoresorption. <h3>Objectives</h3> Our goal was identify attraction signals important...
Abstract Osteoclasts, specialized bone resorbing cells of hematopoietic origin, become overactive in rheumatoid arthritis, leading to loss and joint destruction. Osteoclast progenitor (OCP) arise from myeloid precursors monocyte/macrophage lineage are found the marrow among circulatory monocytes. Under inflammatory conditions subpopulations OCPs undergo through functional phenotypic changes responsible for their increased migration inflamed sites osteoresorptive activity. In our study, we...