A5067803703- Acute Myeloid Leukemia Research
- Retinoids in leukemia and cellular processes
- Metabolism, Diabetes, and Cancer
- PI3K/AKT/mTOR signaling in cancer
- Histone Deacetylase Inhibitors Research
- Acute Lymphoblastic Leukemia research
- Hepatitis B Virus Studies
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Estrogen and related hormone effects
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Drug-Induced Hepatotoxicity and Protection
- Calcium signaling and nucleotide metabolism
- Hepatitis C virus research
- Telomeres, Telomerase, and Senescence
- Bone and Joint Diseases
- Multiple Myeloma Research and Treatments
- Lymphoma Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Carcinogens and Genotoxicity Assessment
- Hematopoietic Stem Cell Transplantation
- Biochemical and Molecular Research
- Mesenchymal stem cell research
- Retinal Development and Disorders
University of Zagreb
2013-2024
University Hospital Centre Zagreb
2024
University of Rijeka
2001
Acute myeloid leukemia (AML) is characterized by arrested differentiation making therapy a promising treatment strategy. Recent success of inhibitors mutated isocitrate dehydrogenase (IDH) invigorated interest in AML so that several new drugs have been proposed, including dihydroorotate (DHODH), an enzyme pyrimidine synthesis. Cytarabine, backbone standard therapy, known to induce at low doses, but the mechanism not completely elucidated. We previously reported 5-aminoimidazole-4-carboxamide...
Pharmacological modulators of AMP-dependent kinase (AMPK) have been suggested in treatment cancer. The biguanide metformin and 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) reported to inhibit proliferation solid tumors hematological malignancies, but their role differentiation is less explored. Our previous study demonstrated that AICAR alone induced AMPK-independent expression markers monocytic U937 leukemia cells, no such effects were observed response metformin. aim this was...
Adenosine monophosphate (AMP)-activated kinase (AMPK) modulators have been shown to exert cytotoxic activity in hematological malignancies, but their role the differentiation of acute myeloid leukemia (AML) is less explored. In this study, effects AMPK agonists on all-trans retinoic acid (ATRA)-mediated promyelocytic (APL) and non-APL AML cell lines were investigated. The results show that inhibit growth myeloblastic HL-60, NB4 monocytic U937 cells. 5-Aminoimidazole-4-carboxamide...
Abstract Recent studies have established a concept of tumour necrosis factor‐α (TNF‐α)/Fas signalling crosstalk, highlighting TNF‐α as critical cytokine in sensitizing hepatocytes to death induced by Fas activation. However, the exact inflammatory response, besides TNF‐α, many other mediators, that might modulate apoptotic response differentially, are released. To resolve issue, we studied effects lipopolysaccharide (LPS), one crucial inductors inflammation liver, on outcome. We show...
Acute myeloid leukemia (AML) is a heterogeneous group of hematological malignancies characterized by differentiation arrest, high relapse rates, and poor survival. The bone marrow (BM) microenvironment recognized as critical mediator drug resistance primary site responsible for AML relapse. Our previous study reported that 5-aminoimidazole-4-carboxamide ribonucleoside (AICAr) induces cell inhibiting pyrimidine synthesis activating Checkpoint kinase 1. Although the protective effect BM stroma...
The genotoxic effects of occupational exposure to ionizing and non-ionizing radiation were investigated in 25 physicians nurses working hospitals 20 individuals at radio-relay stations. Examination was conducted by chromosome aberration analysis peripheral blood lymphocytes. data showed that total number aberrations people exposed radio-frequency (4.08 +/- 0.37 4.35 0.5 on 200 scored metaphases, respectively) almost equally higher than those non-irradiated subjects. increase proportion the...
Rapamycin and its derivatives have been proposed in the treatment of leukemia based on their cytostatic effects, but possible role differentiation therapy is less explored. The aim present study was to investigate beneficial effects combination rapamycin dimethyl sulfoxide (DMSO) growth arrest acute myelogenous (AML) cells. In myeloblastic HL-60, promyelocytic NB4, monocytic U937, immature KG-1 erythro-megakaryocytic K562 cell lines, alone had modest inhibitory DMSO inhibited proliferation a...
Abstract Background All -trans retinoic acid (ATRA)-based treatment of acute promyelocytic leukemia (APL) is the most successful pharmacological myeloid (AML). Recent development inhibitors mutated isocitrate dehydrogenase and dihydroorotate (DHODH) has revived interest in differentiation therapy non-APL AML. Our previous studies demonstrated that 5-aminoimidazole-4-carboxamide ribonucleoside (AICAr) induced monocytic cell lines by activating ATR/Chk1 via pyrimidine depletion. In present...
Low-dose cytarabine (LDAC) is a standard therapy for elderly acute myeloid leukemia (AML) patients unfit intensive chemotherapy. While high doses of induce cytotoxicity, the precise mechanism action LDAC in AML remains elusive. In vitro studies have demonstrated LDAC-induced differentiation; however, such differentiation seldom observed vivo . We hypothesize that this discrepancy may be attributed to influence bone marrow (BM) stromal cells on cells. Thus, study aimed investigate impact BM...
Liver transplantation has become standard practice for treating end-stage liver disease. The success of the procedure relies on effective immunosuppressive medications to control host's immune response. Despite liver's inherent capacity foster tolerance, early post-transplant period is marked by significant reactivity. To ensure favorable outcomes, it imperative identify and manage various rejection types, encompassing T-cell-mediated, antibody-mediated, chronic rejection. However, approach...