A5011421783- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Syncope and Autonomic Disorders
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Cardiac Valve Diseases and Treatments
- Cardiac Arrest and Resuscitation
- Vascular anomalies and interventions
- Heart Rate Variability and Autonomic Control
- Cardiovascular Function and Risk Factors
- Mechanical Circulatory Support Devices
- Venous Thromboembolism Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Cardiac Imaging and Diagnostics
- ECG Monitoring and Analysis
- Health Systems, Economic Evaluations, Quality of Life
- Infective Endocarditis Diagnosis and Management
- Viral Infections and Immunology Research
- Genetic Neurodegenerative Diseases
- Congenital Heart Disease Studies
- Takotsubo Cardiomyopathy and Associated Phenomena
- Thermal Regulation in Medicine
- Central Venous Catheters and Hemodialysis
University of Kansas Medical Center
2012-2024
University of Kansas
2011-2024
The University of Kansas Health System
2011-2020
University Medical Center
2019-2020
University Hospital and Clinics
2019
University of Iowa
2007-2009
Beth Israel Deaconess Hospital
2008
Beth Israel Deaconess Medical Center
2006
National Institute of Neurological Disorders and Stroke
2002-2004
National Institutes of Health
2002-2003
<b><i><i>Background:</i></i></b> Patients with PD often have signs or symptoms of autonomic failure, including orthostatic hypotension. Cardiac sympathetic denervation occurs frequently in PD, but this has been thought to occur independently failure. <b><i><i>Methods:</i></i></b> Forty-one patients (18 and 23 without hypotension) 16 age-matched healthy volunteers underwent PET scanning visualize innervation after injection 6-[<sup>18</sup>F]fluorodopamine. Beat-to-beat blood pressure...
Parkinson's disease patients frequently have symptoms and signs of autonomic nervous dysfunction that are the source considerable disability. Recent studies revealed most with disease, all disease-associated orthostatic hypotension, a loss cardiac sympathetic innervation. Familial caused by mutation gene encoding alpha-synuclein, also features neurocirculatory failure denervation. We recently described whole-gene triplication alpha-synuclein causing Lewy body parkinsonism in large, well...
Combined chemotherapy and radiotherapy increase long-term survival in patients with head neck tumors. Late complications of treatment, however, are being recognized increasingly. Surgery or the carotid sinuses brain stem can evoke labile hypertension orthostatic intolerance from acute subacute baroreflex failure. Here we report cases which chronic failure appeared to develop as a late sequela irradiation. Three referred for autonomic nervous system function testing had blood pressure that...
In postural tachycardia syndrome (POTS) and repeated neurocardiogenic presyncope (NCS), orthostatic intolerance occurs without persistent sympathetic neurocirculatory failure. Whether these conditions involve abnormal cardiac innervation or function has been unclear.Patients with POTS NCS underwent measurements of neurochemical indices release, reuptake, synthesis the neurotransmitter norepinephrine based on entry into venous drainage (cardiac spillover), extraction circulating...
<h3>Importance</h3> Significant differences have been described between women and men regarding presentation, mechanism, treatment outcome of certain arrhythmias. Previous studies ventricular tachycardia (VT) ablation not included sufficient for meaningful comparison. <h3>Objective</h3> To compare outcomes with structural heart disease undergoing VT ablation. <h3>Design, Setting, Participants</h3> Investigator-initiated, multicenter, observational study performed 2002 2013, conducted by the...
This study addressed whether cardiac sympathetic denervation progresses over time in Parkinson's disease. In 9 patients without orthostatic hypotension, 6-[(18)F]fluorodopamine positron emission tomography scanning was repeated after a mean of 2 years from the first scan. 6-[(18)F]fluorodopamine-derived radioactivity less second scan than scan, by 31% left ventricular free wall and 16% septum. disease, loss pattern suggesting dying-back mechanism.
Use of corticosteroids before and after atrial fibrillation (AF) ablation can decrease acute inflammation reduce AF recurrence.To assess the efficacy oral prednisone in improving outcomes pulmonary vein isolation with radiofrequency its effect on inflammatory cytokine.A total 60 patients paroxysmal undergoing were randomized (1:1) to receive either 3 doses mg daily or a placebo. Inflammatory cytokine levels (TNF-α, IL-1, IL6, IL-8) measured at baseline, prior ablation, immediately 24 hours...
In PD, orthostatic hypotension reflects sympathetic noradrenergic denervation. The authors assessed cholinergic innervation by the quantitative sudomotor axon reflex test (QSART) in 12 patients who had neurocirculatory failure, markedly decreased cardiac 6-[18F] fluorodopamine-derived radioactivity, and subnormal plasma norepinephrine increments during standing. All normal QSART results. nervous system lesion PD involves loss of postganglionic catecholaminergic but not nerves.
Abstract Background The safety of perioperative anticoagulation (AC) and antiplatelet (AP) therapy with subcutaneous implantable cardioverter‐defibrillator (S‐ICD) implantation is unknown. purpose this study was to identify the risk factors associated hematoma complicating S‐ICD implantation. Methods Records were retrospectively reviewed from 200 consecutive patients undergoing at two academic medical centers. A defined as a device site blood accumulation requiring surgical evacuation,...
Abstract Introduction Ultrasound guided axillary vein access (UGAVA) is an emerging approach for cardiac implantable electronic device (CIED) implantation not widely utilized. Methods and Results This a retrospective, age sex‐matched cohort study of CIED from January 2017 to July 2019 comparing UGAVA before incision venous obtained after without ultrasound (conventional). The population included 561 patients (187 with attempted UGAVA, 68 ± 13 years old, 43% women, body mass index (BMI) 30 8...