A5086560255- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
- Biological Research and Disease Studies
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Phagocytosis and Immune Regulation
- Cancer Genomics and Diagnostics
- Genomics, phytochemicals, and oxidative stress
- Genomic variations and chromosomal abnormalities
- Arsenic contamination and mitigation
- Pancreatic and Hepatic Oncology Research
- Cancer Research and Treatments
- Circular RNAs in diseases
- Lung Cancer Treatments and Mutations
- Ferroptosis and cancer prognosis
- Glutathione Transferases and Polymorphisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Heavy Metal Exposure and Toxicity
- Neonatal Respiratory Health Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Genomics and Chromatin Dynamics
Zephyr Software (United States)
2022-2024
NYU Langone Health
2021-2023
BC Cancer Agency
2008-2021
New York University
2019
Occupational Cancer Research Centre
2009-2018
Breast Cancer Research Foundation
2017
University of British Columbia
2005-2016
Harvard University
2012-2013
National Institutes of Health
2012-2013
Cancer Research Center
2012
Arsenic is a metalloid, that is, considered to be human carcinogen. Millions of individuals worldwide are chronically exposed through drinking water, with consequences ranging from acute toxicities development malignancies, such as skin and lung cancer. Despite well-known arsenic-related health effects, the molecular mechanisms involved not fully understood; however, arsenic biotransformation process, which includes methylation changes, thought play key role. This paper explores relationship...
Once thought to be a part of the ‘dark matter’ genome, long non-coding RNAs (lncRNAs) are emerging as an integral functional component mammalian transcriptome. LncRNAs novel class mRNA-like transcripts which, despite no known protein-coding potential, demonstrate wide range structural and roles in cellular biology. However, magnitude contribution lncRNA expression normal human tissues cancers has not been investigated comprehensive manner. In this study, we compiled 272 serial analysis gene...
Abstract Human PIWI-interacting RNAs (piRNAs) are known to be expressed in germline cells, functionally silencing LINEs and SINEs. Their expression patterns somatic tissues largely uncharted. We analyzed 6,260 human piRNA transcriptomes derived from non-malignant tumour 11 organs. discovered that only 273 of the 20,831 piRNAs tissues. However, these were able distinguish tissue-of-origin. A total 522 corresponding tissues, distinguishing a cancer-type specific manner. Most mapped...
DNA methylation is an epigenetic modification that highly disrupted in response to cigarette smoke and involved a wide spectrum of malignant nonmalignant diseases, but surprisingly not previously assessed small airways patients with chronic obstructive pulmonary disease (COPD). Small are the primary sites airflow obstruction COPD. We sought determine whether patterns airway epithelia COPD, evaluate changes gene expression associated these disruptions. Genome-wide analysis were performed on...
The genomics era has yielded great advances in the understanding of cancer biology. At same time, immense complexity genome been revealed, as well a striking heterogeneity at whole-genome (or omics) level that exists between even histologically similar tumors. vast accrual and public availability multi-omics databases with associated clinical annotation including tumor histology, patient response, outcome are rich resource potential to lead rapid translation high-throughput omics improved...
Infection with high-risk human papillomavirus (HPV) type 16 is an independent risk factor for the development of oropharyngeal squamous cell carcinomas (OSCC). However, it unclear whether viral integration essential hallmark in carcinogenic process OSCC and HPV correlates level gene transcription influences expression disrupted host genes. We analyzed 75 patients OSCC. HPV16-positivity was proven by p16INK4A immunohistochemistry, PCR FISH. Viral examined using DIPS- as well APOT-PCR. E2, E6...
Chromosomal regions harboring tumor suppressors and oncogenes are often deleted or amplified. Array comparative genomic hybridization detects segmental DNA copy number alterations in relative to a normal control. The recent development of bacterial artificial chromosome array, which spans the human genome tiling path manner with >32,000 clones, has facilitated whole profiling at an unprecedented resolution. Using this technology, we comprehensively describe compare genomes 28 commonly used...
Small cell lung cancer (SCLC) is a highly aggressive neoplasm with extremely poor clinical outcomes and no approved targeted treatments. To elucidate the mechanisms responsible for driving SCLC phenotype in hopes of revealing novel therapeutic targets, we studied copy number methylation profiles SCLC. We found disruption E2F/Rb pathway was prominent feature deregulated 96% samples investigated strongly associated increased expression EZH2, an oncogene core member polycomb repressive complex...
Summary Nodular lymphocyte predominant Hodgkin lymphoma ( NLPHL ) and T cell/histiocyte rich large B cell THRLBCL usually affect middle‐aged men, show tumour cells with a phenotype low content. Whereas the clinical behaviour of is indolent, presents advanced stage disease an aggressive behaviour. In present study, array comparative genomic hybridization was performed in seven typical , four ‐like variants, six diffuse lymphomas DLBCL derived from . The number aberrations higher compared...
Recent evidence suggests that the observed clinical distinctions between lung tumors in smokers and never (NS) extend beyond specific gene mutations, such as EGFR, EML4-ALK, KRAS, some of which have been translated into targeted therapies. However, molecular alterations identified thus far cannot explain all biological disparities NS smokers. To this end, we performed an unbiased genome-wide, comparative study to identify novel genomic aberrations differ NS. High resolution whole genome DNA...
Genomics has substantially changed our approach to cancer research. Gene expression profiling, for example, been utilized delineate subtypes of cancer, and facilitated derivation predictive prognostic signatures. The emergence technologies the high resolution genome-wide description genetic epigenetic features enabled identification a multitude causal DNA events in tumors. This afforded potential large scale integration genome transcriptome data generated from variety technology platforms...
The NRF2 pathway has multiple pro-tumorigenic functions, and Nrf2 levels are increased in head neck squamous cell carcinoma (HNSCC). KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex is a negative regulator of NRF2. In this study, we investigated mechanisms disruption individual components.Clinical genomic profiles for 302 patients with HNSCC were obtained from Cancer Genome Atlas. Combined pattern epi/genetic alterations components revealed frequent disruption. Gene-set enrichment analysis was...
Chronic exposure to arsenic in drinking water poses a major global health concern. Populations exposed high concentrations of arsenic-contaminated suffer serious consequences, including alarming cancer incidence and death rates. Arsenic is biotransformed through sequential addition methyl groups, acquired from s-adenosylmethionine (SAM). Metabolism generates variety genotoxic cytotoxic species, damaging DNA directly indirectly, the generation reactive oxidative species induction adducts,...
Abstract Genetic analyses of lung cancer have helped found new treatments in this disease. We conducted an integrative analysis gene expression and copy number 261 non–small cell cancers (NSCLC) relative to matched normal tissues define novel candidate oncogenes, identifying 12q13-15 more specifically the YEATS4 as amplified overexpressed ∼20% NSCLC cases examined. Overexpression abrogated senescence human bronchial epithelial cells. Conversely, RNAi-mediated attenuation cells reduced their...
Cigarette smoke is associated with the majority of lung cancers: however, 25% cancer patients are non-smokers, and half all newly diagnosed former smokers. Lung tumors exhibit distinct epidemiological, clinical, pathological, molecular features depending on smoking status, suggesting divergent mechanisms underlie tumorigenesis in smokers non-smokers. MicroRNAs (miRNAs) integral contributors to mediate biological responses smoking. Based hypothesis that smoking-specific miRNA differences...
Non-small-cell lung cancer (NSCLC) is an aggressive, highly chemoresistant disease. Reliable prognostic assays and more effective treatments are critically required. BIRC6 (baculoviral inhibitors of apoptosis proteins repeat-containing 6) protein a member the family thought to play important role in progression or chemoresistance many cancers. In this study, we investigated whether expression can be used as marker potential therapeutic target for NSCLC.In retrospective analysis, was...
Reactive oxygen species contribute to normal thyroid function. The NRF2 oxidative response pathway is frequently and constitutively activated in multiple tumor types, including papillary carcinoma (PTC). Genetic mechanisms underlying activation PTC are not fully understood. Thus, we aimed determine whether inactivating patterns of DNA-level alterations affect genes encoding for individual inhibitor complex components (CUL3/KEAP1/RBX1) occur PTC. Combined epi/genetic KEAP1/CUL3/RBX1 E3...
Genes involved in fetal lung development are thought to play crucial roles the malignant transformation of adult cells. Consequently, study tumour biology context has potential reveal key developmentally relevant genes that critical cancer initiation/progression. Here, we describe for first time a comprehensive characterization miRNA expression human tissue, with subsequent identification 37 miRNAs non-small cell (NSCLC) recapitulate their patterns. Nuclear factor I/B (NFIB), transcription...
Microtubule affinity-regulating kinases (MARKs) are involved in several cellular functions but few studies have correlated MARK kinase expression with cancer, and none explored their role lung cancer. In this study, we identified MARK2 as frequently disrupted by DNA hypomethylation copy gain, resulting concordant overexpression independent tumor cohorts demonstrate a for biology. Manipulation of cell lines revealed its involvement viability anchorage-independent growth. Analyses both...
Abstract Background Recent studies have uncovered the near-ubiquitous presence of microbes in solid tumors diverse origins. Previous literature has shown impact specific bacterial species on progression cancer. We propose that local microbial dysbiosis enables certain cancer phenotypes through provisioning essential metabolites directly to tumor cells. Methods 16S rDNA sequencing 75 patient lung samples revealed microbiome specifically enriched for bacteria capable producing methionine....
Arsenic is a potent human carcinogen. Around one hundred million people worldwide have potentially been exposed to this metalloid at concentrations considered unsafe. Exposure occurs generally through drinking water from natural geological sources, making it difficult control contamination. biotransformation suspected role in arsenic-related health effects ranging acute toxicities development of malignancies associated with chronic exposure. It has demonstrated that arsenic exhibits...