A5019690107- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Diagnosis and Treatment
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Global Cancer Incidence and Screening
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Delphi Technique in Research
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- RNA modifications and cancer
- Smoking Behavior and Cessation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- MicroRNA in disease regulation
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Cancer Studies
- Respiratory viral infections research
- Machine Learning in Bioinformatics
- Epigenetics and DNA Methylation
- Heterotopic Ossification and Related Conditions
- Medical Imaging and Pathology Studies
- Economic and Financial Impacts of Cancer
- Vasculitis and related conditions
- Nutrition and Health in Aging
- Pediatric health and respiratory diseases
Boston University
2015-2024
GTx (United States)
2024
Boston Medical Center
2007-2023
University Medical Center
2007-2023
University School
2016-2021
Osaka University
2020
Institute for Biomedicine
2013
Vanderbilt University
2012
University of Minnesota
2012
BC Cancer Agency
2012
Rationale: Chronic obstructive pulmonary disease (COPD) is a heterogeneous and likely includes subgroup that biologically comparable to asthma. Studying asthma-associated gene expression changes in COPD could add insight into pathogenesis reveal biomarkers predict favorable response corticosteroids.Objectives: To determine whether signatures are increased associated with asthma-related features.Methods: We compared disease-associated airway epithelial alterations an asthma cohort (n = 105)...
Cigarette smoking is a leading cause of preventable death and significant lung cancer chronic obstructive pulmonary disease. Prior studies have demonstrated that creates field molecular injury throughout the airway epithelium exposed to cigarette smoke. We previously characterized gene expression in bronchial never smokers identified changes occur mainstem bronchus response smoking. In this study, we explored relationships whole-genome between extrathorcic (buccal nasal) intrathoracic...
Rationale: Molecular phenotyping of chronic obstructive pulmonary disease (COPD) has been impeded in part by the difficulty obtaining lung tissue samples from individuals with impaired function.Objectives: We sought to determine whether COPD-associated processes are reflected gene expression profiles bronchial airway epithelial cells obtained bronchoscopy.Methods: Gene profiling brushings 238 current and former smokers without COPD was performed using Affymetrix Human 1.0 ST...
DNA methylation is an epigenetic modification that highly disrupted in response to cigarette smoke and involved a wide spectrum of malignant nonmalignant diseases, but surprisingly not previously assessed small airways patients with chronic obstructive pulmonary disease (COPD). Small are the primary sites airflow obstruction COPD. We sought determine whether patterns airway epithelia COPD, evaluate changes gene expression associated these disruptions. Genome-wide analysis were performed on...
Abstract Hyperinflation contributes to dyspnea intensity in COPD. Little is known about the molecular mechanisms underlying hyperinflation and how inhaled corticosteroids (ICS) affect this important aspect of COPD pathophysiology. To investigate effect ICS/long-acting β 2 -agonist (LABA) treatment on both lung function measures hyperinflation, nasal epithelial gene-expression profile severe 117 patients were screened 60 entered a 1-month run-in period low-dose ICS/LABA budesonide/formoterol...
Abstract Lung cancer is the leading cause of death due, in part, to lack early diagnostic tools. Bronchoscopy represents a relatively noninvasive initial test smokers with suspect disease, but it has low sensitivity. We have reported gene expression profile cytologically normal large airway epithelium obtained via bronchoscopic brushings, which sensitive and specific biomarker for lung cancer. Here, we evaluate independence from other clinical risk factors determine performance...
Background Although prior studies have demonstrated a smoking-induced field of molecular injury throughout the lung and airway, impact smoking on airway epithelial proteome its relationship to smoking-related changes in transcriptome are unclear. Methodology/Principal Findings Airway cells were obtained from never (n = 5) current smokers by brushing mainstem bronchus. Proteins separated one dimensional polyacrylamide gel electrophoresis (1D-PAGE). After in-gel digestion, tryptic peptides...
<h3>Background</h3> A core feature of chronic obstructive pulmonary disease (COPD) is the accelerated decline in forced expiratory volume one second (FEV<sub>1</sub>). The recent Groningen and Leiden Universities study Corticosteroids Obstructive Lung Disease (GLUCOLD) suggested that particular phenotypes COPD benefit from fluticasone±salmeterol by reducing rate FEV<sub>1</sub> decline, yet underlying mechanisms are unknown. <h3>Methods</h3> Whole-genome gene expression profiling using...
Section:ChooseTop of pageAbstract <<TRANSCRIPTOMIC STUDIES OF...DOES THE COMMON AIRWAY FI...TRANSCRIPTOMIC OF...TRANSCRIPTOMIC OF...FUTURE DIRECTIONSReferencesCITING ARTICLES
Nasal gene expression profiling is a promising method to characterize COPD non-invasively. We aimed identify nasal profile distinguish patients from healthy controls. investigated whether this COPD-associated in epithelium comparable with the observed bronchial epithelium. Genome wide analysis was performed on epithelial brushes of 31 severe and 22 controls, all current smokers, using Affymetrix Human Gene 1.0 ST Arrays. repeated 2 independent cohorts mild-to-moderate In epithelium, 135...
<h3>Background</h3> COPD is a complex chronic disease with poorly understood pathogenesis. Integrative genomic approaches have the potential to elucidate biological networks underlying and lung function. We recently combined genome-wide genotyping gene expression in 1111 human specimens map quantitative trait loci (eQTL). <h3>Objective</h3> To determine causal associations between function-associated single nucleotide polymorphisms (SNPs) tissue changes our eQTL dataset. <h3>Methods</h3>...
The aim was to investigate whether microRNA (miRNA) expression is modulated by inhaled corticosteroid (ICS) treatmentWe performed genome-wide miRNA analysis on bronchial biopsies of 69 moderate/severe chronic obstructive pulmonary disease (COPD) patients at baseline and after 6- 30-month treatment with the ICS fluticasone propionate or placebo. effect validated in differentiated primary epithelial cultures, functional studies were conducted BEAS-2B cells. MiRNAs affected their predicted...
Lung cancer remains the leading cause of cancer-related death in United States. Cigarette smoking is a well-recognized risk factor for lung cancer, and sustained elevation persists even after cessation. Despite identifiable factors, there has been minimal improvement mortality patients with primarily stemming from diagnosis at late stage when are few effective therapeutic options. Early detection screening high-risk individuals may help improve mortality. While low dose computerized...
Objective To determine whether disease processes related to granulomatosis with polyangiitis (Wegener's) (GPA) are reflected in gene expression profiles of the nasal mucosa. Methods Nasal brushings inferior turbinate were obtained from 32 patients GPA (10 active disease, 13 prior and 9 no history disease) a composite comparator group without inflammatory (12 healthy people, 15 sarcoidosis, 8 allergic rhinitis). Differential was assessed between subgroups comparators. Results A total 339...
In China's rural counties of Xuanwei and Fuyuan, lung cancer rates are among the highest in world. While elevated disease risk this population has been linked to usage smoky (bituminous) coal as compared smokeless (anthracite) coal, underlying molecular changes associated with exposure remains unclear. To understand physiologic effects exposure, we analyzed genome-wide gene-expression profiles buccal epithelial cells collected from healthy, non-smoking female residents Fuyuan who burn ( n =...