A5030633284- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Parasites and Host Interactions
- Toxin Mechanisms and Immunotoxins
- Insect symbiosis and bacterial influences
- Synthesis and Biological Evaluation
- Dermatological diseases and infestations
- Garlic and Onion Studies
- Primate Behavior and Ecology
- Rabies epidemiology and control
- Insect and Pesticide Research
- Fungal Plant Pathogen Control
- Vector-borne infectious diseases
- Helminth infection and control
- Parasite Biology and Host Interactions
Autonomous University of Yucatán
2014-2025
Fundar
2024
Dogs play a crucial role in the transmission cycle of Trypanosoma cruzi and their presence domicile increases risk infection humans. In Yucatán, Mexico previous studies have reported T. dogs from both rural urban areas, which we expanded here, to better understand dynamics. A total 186-dogs were screened for by PCR serology. Parasite burden, genotype, immune response, cardiac alterations, roaming behavior analyzed. The prevalence was 26.8% (50/186). Genotyping revealed predominance TcI...
A therapeutic vaccine for human Chagas disease (American trypanosomiasis caused by Trypanosoma cruzi) is under development based on the success of vaccinating mice with DNA constructs expressing antigens Tc24 and Tc-TSA-1. However, because nucleic acid vaccines produce less than optimal responses in humans, our strategy relies administering a recombinant protein-based vaccine, together adjuvants that promote Th1-type immunity. Here we describe process purification refolding TSA-1 expressed...
Background Chagas disease (CD) is caused by Trypanosoma cruzi and affects 6–7 million people worldwide. Approximately 30% of chronic patients develop chagasic cardiomyopathy (CCC) after decades. Benznidazole (BNZ), one the first-line chemotherapy used for CD, induces toxicity fails to halt progression CCC in patients. The recombinant parasite-derived antigens, including Tc24, Tc24-C4, TSA-1, TSA-1-C4 with Toll-like receptor 4 (TLR-4) agonist-adjuvants reduce cardiac parasite burdens, heart...
Chagas disease is caused by the protozoan parasite Trypanosoma cruzi, and activation of CD8+ T cells crucial for a protective immune response. Therefore, identification antigens with major histocompatibility complex class I epitopes step vaccine development against T. cruzi. Our aim was to identify novel immunoinformatics analysis proteome (12 969 proteins) validate their immunotherapeutic potential in infected mice. We identified 172 predicted epitopes, using NetMHC RANKPEP. The...
Cutaneous leishmaniasis is a tropical disease affecting over one million patients annually and Leishmania (L.) mexicana of the major etiological agents in Americas. Here we established first experimental infection L. canids. Beagle dogs were infected intradermally with culture-derived mexicana. We followed skin ulcer development, histopathological signs, parasite burden immune status dogs. All developed uniform oval-craterform ulcers similar to those observed humans, associated mixed T...
Parasitic diseases cause ∼ 500,000 deaths annually and remain a major challenge for therapeutic development. Using rational design based approach, we developed peptide inhibitors with anti-parasitic activity that were derived from the sequences of parasite scaffold proteins LACK (Leishmania's receptor activated C-kinase) TRACK (Trypanosoma C-kinase). We hypothesized in are conserved parasites, but not mammalian ortholog, RACK (Receptor C-kinase), may be interaction sites signaling critical...
In the present study, helminths from six Didelphis virginiana and one Philander vossi are reported using morphological techniques (clearing, staining, scanning electron microscopy). Additionally, 28S rRNA sequences of individuals nine helminth taxa provided. Phylogenetic analyses were performed with new to confirm identification genealogical relationships parasites. Thirteen identified, comprising trematodes Brachylaima sp. Platynosomum illiciens, cestode Mathevotaenia sp., nematodes Cruzia...
The objective of this study was to determine the seroprevalence Ehrlichia spp. in dogs from Xcalak, Quintana Roo, Mexico, and associated factors. Serum samples were obtained 118 used an indirect immunofluorescent assay test for detection antibodies against A questionnaire obtain information about possible variables with seroprevalence. These analyzed through Chi 2 logistic regression. Dog 64% (75/118). Fifty-two percent (61/118) had tick infestation which identified as Rhipicephalus...
Abstract Background Chagas disease (CD) is caused by Trypanosoma cruzi and affects 6-7 million people worldwide. Approximately 30% of chronic patients develop chagasic cardiomyopathy (CCC) after decades. Benznidazole (BNZ), one the first-line chemotherapy approved for CD, induces toxicity fails to halt progression CCC in patients. The recombinant parasite-derived antigens, including Tc24, Tc24-C4, TSA-1, TSA-1-C4 with Toll-like receptor 4 (TLR-4) agonist-adjuvants reduce cardiac parasite...
Background Trypanosoma cruzi is mainly transmitted to mammals by vectors, but other transmission routes exist. Opossums can harbor the infectious form of parasite in their anal glands, underscoring potential role non-vectorial transmission. In Mexico, Didelphis virginiana and D . marsupialis are main opossum species. While T has been detected gland secretions various species, infectivity only confirmed albiventris Vertical also proposed However, if this occurs opossums, it remains unclear...
Abstract