A5076635917- Receptor Mechanisms and Signaling
- Protein Kinase Regulation and GTPase Signaling
- Trypanosoma species research and implications
- T-cell and Retrovirus Studies
- Stress Responses and Cortisol
- Research on Leishmaniasis Studies
- 14-3-3 protein interactions
- Neuropeptides and Animal Physiology
- Brucella: diagnosis, epidemiology, treatment
- PI3K/AKT/mTOR signaling in cancer
- Pain Mechanisms and Treatments
- Hormonal Regulation and Hypertension
- Microtubule and mitosis dynamics
- Burkholderia infections and melioidosis
- Herpesvirus Infections and Treatments
- Salmonella and Campylobacter epidemiology
- Chronic Lymphocytic Leukemia Research
- Computational Drug Discovery Methods
- Vector-Borne Animal Diseases
- Viral Infectious Diseases and Gene Expression in Insects
- Enzyme Structure and Function
- Fungal Biology and Applications
- Protein Degradation and Inhibitors
- Mosquito-borne diseases and control
- Ubiquitin and proteasome pathways
Fundación Universitaria San Pablo CEU
2020
Universidade de São Paulo
2013-2018
Icahn School of Medicine at Mount Sinai
2016
Universidade Federal de Santa Catarina
2011
Universidade Federal de Viçosa
2006
Kinases can recognize consensus motifs that are noncontiguous in folded proteins.
Background. Chagas disease is caused by the protozoan parasite Trypanosoma cruzi, which exhibits a high genetic variability. TcI, TcII, or mixed TcI/TcII strains may be found during acute human infection while mainly TcII parasites are present at chronic stage of disease. In previously studied outbreak, we identified in vector Triatoma tibiamaculata and only infected humans, indicating that T. cruzi populations selected within host. Methods. Utilizing molecular typing cell biology...
Parasitic diseases cause ∼ 500,000 deaths annually and remain a major challenge for therapeutic development. Using rational design based approach, we developed peptide inhibitors with anti-parasitic activity that were derived from the sequences of parasite scaffold proteins LACK (Leishmania's receptor activated C-kinase) TRACK (Trypanosoma C-kinase). We hypothesized in are conserved parasites, but not mammalian ortholog, RACK (Receptor C-kinase), may be interaction sites signaling critical...
Os vírus da anemia infecciosa eqüina (EIAV), influenza tipo 2 (EIV-2) e o herpesvírus eqüino 1 (EHV-1) são agentes causadores de enfermidades que podem causar graves prejuízos econômicos. O objetivo deste presente estudo foi estimar a freqüência anticorpos contra EIAV, EIV-2 EHV-1 em rebanhos do sul Estado Pará, Brasil. foram detectados pelo teste IDGA, método inibição hemaglutinação pela técnica soroneutralização (TCID50 =100), respectivamente. Amostras sangue 672, 514 506 equídeos...
Protein kinase C (PKC) plays a regulatory role in key pathways cancer. However, since phosphorylation is step for classical PKC (cPKC) maturation and does not correlate with activation, there lack of tools to detect active tissue samples. Here, structure-based rational approach was used select peptide generate an antibody that distinguishes from inactive cPKC. A conserved all cPKCs, C2Cat, chosen modeling studies based on crystal structure PKCβ showed it localized at the interface between C2...
RESUMO A brucelose equina é causada pela Brucella abortus e se manifesta principalmente através de fístulas na região da cernelha, que podem ser fonte infecção para humanos. por B. em equídeos ocorre pelo contato com bovinos infectados. O objetivo do presente estudo foi estimar a frequência anticorpos contra equideos procedentes Zona Mata Estado Minas Gerais, Brasil. Um total 477 amostras soros provenientes saudáveis foram examinados meio prova Antígeno Acidificado Tamponado (AAT)...
Recently we deorphanized GPR171, a hypothalamic G protein‐coupled receptor, as the receptor for abundant neuropeptide, Big‐LEN. By virtual screening of library small molecules, identified compounds that selectively target GPR171. Using these found activation GPR171 within hypothalamus regulates feeding. Additional characterization distribution revealed high expression in basolateral amygdala. This led us to explore role various stress and reward‐related behaviors using lentiviral...
ProSAAS derived peptides, such as BigLEN, are abundantly expressed throughout the brain. We recently identified BigLEN endogenous peptide for orphan receptor GPR171. Immunohistochemical analysis shows that both and GPR171 highly in areas of brain involved opioid function, nucleus accumbens (NAc), medial prefrontal cortex (mPFC), basolateral amygdala (BLA). C57bl/6 mice showed an increase mRNA expression NAc BLA following conditioned place preference to morphine. Whereas there was no change...
Abstract The protein kinase C (PKC) family of serine/ threonine kinases has been shown to play active roles as either suppressors or promoters carcinogenesis in different types tumors. Using antibodies that preferentially recognize the conformation classical PKCs (cPKCs), we have previously breast cancer samples expression levels cPKCs were similar estrogen receptor–positive (ER + ) compared triple‐negative tumors; however, different. Determining activation status and other tumors may thus...