A5100438281- Aortic aneurysm repair treatments
- Epigenetics and DNA Methylation
- Coronary Interventions and Diagnostics
- Aortic Disease and Treatment Approaches
- MicroRNA in disease regulation
- Music and Audio Processing
- Phonocardiography and Auscultation Techniques
- Peripheral Artery Disease Management
- Macrophage Migration Inhibitory Factor
- Cancer-related molecular mechanisms research
- EEG and Brain-Computer Interfaces
- Vascular Procedures and Complications
- Cerebrovascular and Carotid Artery Diseases
- Neuroscience and Neuropharmacology Research
- Genomic variations and chromosomal abnormalities
- Epilepsy research and treatment
- Neural Networks and Applications
- Cancer, Hypoxia, and Metabolism
- Methemoglobinemia and Tumor Lysis Syndrome
- Cancer Mechanisms and Therapy
- Tea Polyphenols and Effects
- Advanced Graph Neural Networks
- Pain Management and Treatment
- Acute Kidney Injury Research
- Machine Learning and Data Classification
Qingdao University of Science and Technology
2025
Xuzhou Medical College
2024-2025
Shandong First Medical University
2025
First Affiliated Hospital of Guangzhou Medical University
2025
National University of Defense Technology
2024
Harbin Medical University
2014-2024
First Affiliated Hospital of Harbin Medical University
2013-2024
Affiliated Hospital of Xuzhou Medical College
2024
Nanjing Medical University
2019-2022
The Affiliated Yongchuan Hospital of Chongqing Medical University
2019-2022
Abstract Necroptosis, or programmed necrosis, contributes to the formation of necrotic cores in atherosclerotic plaque animal models. However, whether inhibition necroptosis ameliorates atherosclerosis is largely unknown. In this study, we demonstrated that occurred clinical samples, suggesting it may also play an important role human atherosclerosis. We established vitro necroptotic model which was induced THP-1-derived foam cells by serum deprivation. With model, 5-aminolevulinic...
Abstract Ethnopharmacological relevance: Dark Tea (DT) is a traditional health beverage in China, and regular consumption can effectively mitigate vascular lesions induced by hyperlipidemia. However, key active ingredient of DT the potential pharmacological mechanism protecting endothelium still unclear.Aim study: The aim this study was to investigate reveal underlying responsible for its protective effect on endothelium.Materials methods: evaluated using high-fat zebrafish model. chemical...
Abstract Objectives Abdominal aortic aneurysm (AAA) is an inflammation-driven disease in which neutrophil infiltration critical to its progression. This study aims explore the molecular mechanisms behind AAA and identify key regulatory genes. Methods We utilized weighted gene co-expression network analysis (WGCNA) differential expression compare healthy abdominal tissues. Functional enrichment a protein–protein interaction (PPI) were constructed understand functions. Machine learning...
Glioma is one of the most common types primary brain tumors. Ivermectin (IVM), a broad-spectrum antiparasitic drug, has been identified as novel anticancer agent due to its inhibitory effects on proliferation glioma cells in vitro and vivo. However, ability IVM induce autophagy role cell death remains unclear. The main objective present study was explore induced by U251 C6 cells, deep underlying molecular mechanisms. In addition, we examined apoptosis cells. study, transmission electron...
MicroRNAs (miRNAs) are deregulated in various vascular ailments including abdominal aortic aneurysm (AAA). MiR-103 is involved vascular, metabolic, and malignant diseases, but whether it participates the pathogenesis of AAA remains elusive. ADAM10 plays a vital role formation aneurysm, miRs modulate its activity during totally unknown. In this study, we detected significantly increased protein expression angiotensin II induced murine specimens, while mRNA was similar between control,...
Background and aimsAbdominal aortic aneurysm (AAA) is a life-threatening vascular disease when rupture occurs, especially for elders. There an urgent need to understand the mechanisms of AAA formation development at molecular level. Our previous study showed that disintegrin metalloprotease 10 (ADAM10) played important role in abdominal formation. In this study, we investigated effects another ADAM protein (ADMA9) formation.Method resultsUsing AngII treated human smooth muscle cells (HASMCs)...
Mesenchymal stromal/stem cells (MSCs) are promising carriers in cell-based therapies against central nervous system diseases, and have been evaluated various clinical trials recent years.However, bone marrowderived MSCs (BMSCs) reportedly involved tumorigenesis initiated by glioma stem-like (GSCs).We therefore established three different orthotopic models of GSC-MSC interactions vivo using dual-color fluorescence tracing.Cell sorting micropipetting techniques were used to obtain highly...
Background: Accumulating evidence suggests that the principal TNF-α converting enzyme, a disintegrin and metalloproteinase 17 (ADAM17), is involved in development of human abdominal aortic aneurysm (AAA). However, association between ADAM17 gene polymorphisms AAA has not been explored. The present study was aimed to determine promoter AAA. Methods: A total 316 patients with 306 age-matched healthy controls were enrolled this study. Two (rs12692386 rs1524668) determind. Real-time PCR employed...
Glioblastoma multiform is one of the most common and aggressive brain tumors in humans. The molecular cellular mechanisms responsible for onset progression GBM are elusive controversial. function tumor suppressor candidate 3 (TUSC3) has not been previously characterized GBM. TUSC3 was originally identified as part an enzyme complex involved N-glycosylation proteins, but recently implicated a potential gene variety cancer types. In this study, we demonstrated that expression levels were...
The aim of this study was to evaluate the effect artemisinin on proliferation and apoptosis rat vascular smooth muscle cells (VSMCs). Primary VSMCs were treated with various doses artemisinin. Cell evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, messenger RNA protein expressions proliferating cell nuclear antigen determined reverse-transcription polymerase chain reaction immunohistochemistry. Apoptosis measured using annexin V propidium iodide double staining...
Glioblastoma multiforme (GBM), one of the most aggressive human malignant brain tumors, is induced by multiple complex pathological mechanisms. The main cause mortality in patients with GBM invasion‑metastasis cascade tumor cells. dysfunction Parkinson protein 2 E3 ubiquitin ligase (PARK2) closely linked development certain cancers. However, whether PARK2 associated metastasis remains unknown. present study demonstrated that and invasion U87 cells were significantly repressed overexpression....
The present study was designed to investigate the role of circulating miRNA-21 (miR-21) in vascular restenosis lower extremity arterial occlusive disease (LEAOD) patients after interventional therapy. A total 412 LEAOD were enrolled randomly study. According computed tomography angiography (CTA) and ankle-brachial index (ABI), assigned into group non-restenosis group. miR-21 expression detected with quantitative real-time PCR (qRT-PCR) before underwent follow-up period 6 months achieved....
Abstract Background Abdominal aortic aneurysm (AAA) is a highly lethal cardiovascular disease. The aim of this research to identify new biomarkers and therapeutic targets for the treatment such deadly diseases. Methods Single-sample gene set enrichment analysis (ssGSEA) CIBERSORT algorithms were used distinct immune cell infiltration types between AAA normal abdominal aortas. Single-cell RNA sequencing data analyse hallmark genes AAA-associated macrophage subsets. Six macrophage-related hub...
We determined whether low bilirubin level is a risk factor for peripheral arterial disease (PAD). recruited 318 patients with PAD and 100 healthy volunteers. Patients were divided into 4 groups by the Fontaine classification PAD, namely, group 1 (grade 1, n = 4); 2 2, 114), 3 3, 164), 4, 36). Total (T-BIL), direct (D-BIL), indirect (I-BIL) levels compared using stepwise multiple regressions adjusted selected factors. After adjusting gender, age, smoking, diastolic blood pressure, serum of...