A5010382497- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Receptor Mechanisms and Signaling
- Virology and Viral Diseases
- Neuroscience and Neuropharmacology Research
- Mitochondrial Function and Pathology
- Bipolar Disorder and Treatment
- Neuropeptides and Animal Physiology
- Synthetic Organic Chemistry Methods
- Heat shock proteins research
- Memory and Neural Mechanisms
- Muscle metabolism and nutrition
- Adipose Tissue and Metabolism
- Sleep and Wakefulness Research
- Mosquito-borne diseases and control
- Cardiac Ischemia and Reperfusion
- Trace Elements in Health
- Cardiovascular Disease and Adiposity
- Ion channel regulation and function
- Radiation Therapy and Dosimetry
- Genetic Syndromes and Imprinting
- Nerve injury and regeneration
- Muscle Physiology and Disorders
- Parathyroid Disorders and Treatments
- Child Nutrition and Feeding Issues
Centre National de la Recherche Scientifique
2006-2021
Université de Toulouse
2008-2021
Inserm
2014-2021
Université Toulouse III - Paul Sabatier
2006-2021
Centre de Physiopathologie de Toulouse-Purpan
2014-2020
Nelson Engineering (United States)
2020
University of California, San Francisco
2017-2018
Institut Cellule Souche et Cerveau
2015
Université Claude Bernard Lyon 1
2015
Centre de Recherches sur la Cognition Animale
2006-2009
Background:Recent studies revealed that bipolar disorder may be associated with deficits of neuroplasticity. Additionally, accumulating evidence has implicated alterations the intracellular signaling molecule protein kinase C (PKC) in mania.
Disruption in copper homeostasis causes a number of cognitive and motor deficits. Wilson's disease Menkes are neurodevelopmental disorders resulting from mutations the transporters ATP7A ATP7B, with also causing occipital horn syndrome, distal neuropathy. A 65 year old male presenting brachial amyotrophic diplegia diagnosed lateral sclerosis (ALS) was found to harbor p.Met1311Val (M1311V) substitution variant ATP7A. ALS is fatal neurodegenerative associated progressive muscle weakness,...
ABSTRACT Understanding the modalities of interaction neurotropic viruses with their target cells represents a major challenge that may improve our knowledge many human neurological disorders for which viral origin is suspected. Borna disease virus (BDV) an ideal model to analyze molecular mechanisms persistence in neurons and its consequences neuronal homeostasis. It now established BDV ensures long-term maintenance infected through stable components host cell chromatin, particular, core...
Abstract Mortalin is a mitochondrial chaperone protein involved in quality control of proteins imported into the matrix, which was recently described as sensor neuronal stress. down-regulated neurons patients with neurodegenerative diseases and levels expression are correlated fate animal models Alzheimer's disease or cerebral ischemia. To date, however, links between levels, its impact on function morphology and, ultimately, initiation neurodegeneration, still unclear. In present study, we...
Significance As obligate parasites, viruses have evolved strategies to hijack cellular pathways and persist in their host, sometimes without causing overt diseases. such, they represent unique tools decipher functions consequences on host physiology. Here, we exploited the natural property of a virus-encoded protein known act as decoy substrate for kinase C (PKC), pathway thought play key roles learning memory processes. When selectively expressed hippocampal dentate gyrus mice, this caused...
INTRODUCTION: Oral administration of riluzole is the only Food and Drug Administration-approved therapy for amyotrophic lateral sclerosis (ALS). However, per os has shown modest efficacy limited by its negative impact on liver function. We hypothesize that intrathecal (IT) will significantly improve drug increasing local concentrations at targeted spinal cord segments, while circumventing peripheral toxicity. METHODS: A programmable infusion pump (SynchroMed II) connected to an IT catheter...
Riluzole is the only treatment known to improve survival in patients with Amyotrophic Lateral Sclerosis (ALS). However, oral riluzole efficacy modest at best, further it have large inter-individual variability of serum concentration and clearance, formulated as an drug a patient population plagued dysphagia, has systemic side-effects like asthenia (limiting compliance) elevated liver enzymes. In this context, we postulated that continuous intrathecal (IT) infusion low doses could provide...
Abstract Mortalin is a mitochondrial chaperone protein involved in quality control of proteins imported into the matrix, which was recently described as sensor neuronal stress. down-regulated neurons patients with neurodegenerative diseases and levels expression are correlated fate animal models Alzheimer's disease or cerebral ischemia. To date, however, links between levels, its impact on function morphology and, ultimately, initiation neurodegeneration, still unclear. In present study, we...
Abstract Aging is the primary risk factor for Parkinson’s disease (PD) and cognitive impairment from PD a major unmet biomedical challenge. Klotho, pleiotropic protein, extends lifespan enhances cognition. Whether longevity factors such as klotho can counteract PD-related mortality deficits in mice or associate with resistance to humans unknown. Here we show that transgenic elevation of increased lifespan, improved synaptic cognitive, but not motor, functions mice, decreased steady state...
Summary Riluzole is the only treatment known to improve survival in patients with Amyotrophic Lateral Sclerosis (ALS). However, oral riluzole efficacy modest at best, further it have large inter-individual variability of serum concentration and clearance, formulated as an drug a patient population plagued dysphagia, has systemic side-effects like asthenia (limiting compliance) elevated liver enzymes. In this context, we postulated that continuous intrathecal (IT) infusion low doses could...