A5037023113- Bone fractures and treatments
- Orthopaedic implants and arthroplasty
- 3D Printing in Biomedical Research
- Hip and Femur Fractures
- Bone Tissue Engineering Materials
- Shoulder and Clavicle Injuries
- Shoulder Injury and Treatment
- Additive Manufacturing and 3D Printing Technologies
- Lower Extremity Biomechanics and Pathologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Spine and Intervertebral Disc Pathology
- Effects of Vibration on Health
- Pelvic and Acetabular Injuries
- Spinal Fractures and Fixation Techniques
- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Diabetic Foot Ulcer Assessment and Management
- Robotic Mechanisms and Dynamics
- Hip disorders and treatments
- Soil Mechanics and Vehicle Dynamics
- Cell Image Analysis Techniques
- Thin-Film Transistor Technologies
- Structural Analysis and Optimization
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Nerve Injury and Rehabilitation
Pennsylvania State University
2013-2024
Penn State Milton S. Hershey Medical Center
2013-2024
University Orthopedics Center
2022
National Institute of Biomedical Imaging and Bioengineering
2021
Kitware (United States)
2021
Reid Health
2021
Johnson & Johnson (Brazil)
2021
Zimmer Biomet (France)
2021
Orthopaedic Trauma Association
2015
Pennsylvania Department of Health
2015
Abstract Reconstruction of complex craniomaxillofacial (CMF) defects is challenging due to the highly organized layering multiple tissue types. Such compartmentalization necessitates precise and effective use cells other biologics recapitulate native anatomy. In this study, intra‐operative bioprinting (IOB) different CMF tissues, including bone, skin, composite (hard/soft) demonstrated directly on rats in a surgical setting. A novel extrudable osteogenic hard ink introduced, which induced...
Abstract Conventional top-down approaches in tissue engineering involving cell seeding on scaffolds have been widely used bone applications. However, scaffold-based constructs had limited clinical translation due to constrains supporting scaffolds, minimal flexibility tuning scaffold degradation, and low achievable density as compared with native tissue. Here, we demonstrate a pragmatic scalable bottom-up method, inspired from embryonic developmental biology, build three-dimensional (3D)...
The biomechanical difficulty in fixation of a Vancouver B1 periprosthetic fracture is purchase the proximal femoral segment presence hip stem. Several newer technologies provide ability to place bicortical locking screws tangential stem with much longer lengths screw compared unicortical screws. This study compares stability 2 these constructs previous methods.Thirty composite synthetic femurs were prepared cemented stems. distal femur was osteotomized, and plates fixed proximally either (1)...
Proximal femur fracture fixation with intramedullary nailing relies on stability at the site and integrity of construct to achieve union. The biomechanics that dictate implant stress depend type as well features such nail length, diameter, presence distal screws, material composition implant. When deciding how fix a fracture, surgeons have choices in these implant-related design variables. This study models all combinations range variables for nine standard AO/OTA proximal fractures using...
Gene therapeutic applications combined with bio- and nano-materials have been used to address current shortcomings in bone tissue engineering due their feasibility, safety potential capability for clinical translation. Delivery of non-viral vectors can be altered using gene-activated matrices improve efficacy repair defects.Ex-situandin-situdelivery strategies are the most methods therapy, which never directly compared potency critical-sized defects. In this regard, we first time explore...
Aseptic loosening of cemented joint replacements is a complex biological and mechanical process, remains clinical concern especially in patients with poor bone quality. Utilizing high resolution finite element analysis series implanted cadaver glenoids, the objective this study was to quantify relationships between construct morphology resulting stresses cement trabeculae. Eight glenoid cadavers were central peg implant. Specimens imaged by micro-CT, subject-specific models developed. Bone...
OBJECTIVES: A variable pitch locking screw is intended to provide interfragmentary compression combined with fixed angle stability of plate constructs. The objective this study was compare screws (3.5-mm KreuLock Ti screws, Arthrex Inc., Naples, FL) standard (from the same manufacturer) in bicortical fixation scenarios cadaver bone by assessing (1) and plate-bone (2) construct biomechanical stability. METHODS: Nine matched pairs fresh-frozen cadaveric specimens an average age 67.2 years...
Internal fixation with the use of locking plates is standard surgical treatment for proximal humerus fractures, one most common fractures in elderly. Screw cut-out through weak cancellous bone humeral head, which ultimately results collapse fixed fracture, leading cause failure and revision surgery. In an attempt to address this problem, surgeons often attach plate as many screws possible into fragment. It not thoroughly understood screw combinations play critical roles stability. This study...
In bone cell culturing environment, mechanical vibration has been utilized to study the effects of various frequency and amplitude conditions on cells. this study, a spreading single was modeled as simple dome investigate dynamic properties in environment. The finite element modal analysis applied evaluate natural mode shapes cell. variance such Young's modulus were utilized. Simulation results show that range for sizes (135×30, 100×40, 80×50, 67×60 μm with 10 height) is 9.95-211.05 Hz do...
The time-course of cancellous bone regeneration surrounding mechanically loaded implants affects implant fixation, and is relevant to determining optimal rehabilitation protocols following orthopaedic surgeries. We investigated the influence controlled mechanical loading titanium-coated polyether-ether ketone (PEEK) on osseointegration using time-lapsed, non-invasive, in vivo micro-computed tomography (micro-CT) scans. Implants were inserted into proximal tibial metaphyses both limbs eight...
Micro-computed tomography (µCT) is the most common imaging modality to characterize three-dimensional (3D) morphology of bone and newly formed during fracture healing in translational science investigations. Studies long rodents typically involve secondary formation a mineralized callus. The shape callus density may vary substantially between timepoints treatments. Whereas standard methodologies for quantifying parameters intact cortical trabecular are widely used embedded commercially...
Abstract Conventional top-down approaches in tissue engineering involving cell seeding on scaffolds have been widely used bone applications. However, scaffold-based constructs had limited clinical translation due to constrains supporting scaffolds, minimal flexibility tuning scaffold degradation, and low achievable density as compared with native tissue. Here, we demonstrate a pragmatic scalable bottom-up method, inspired from embryonic developmental biology, build three-dimensional (3D)...
In the surgical fixation of fractures, proper biomechanical stability is key in preventing clinical complications including poor fracture healing, residual deformity, loss fixation, or implant failure. Stability largely influenced by treatment decisions made surgeon. The interplay surgeon-controlled variables and their effect on three-dimensional (3D) biomechanics a construct are often not intuitive, current training methods do facilitate deep understanding these interactions.A simulation...
This retrospective study investigated associations of rotator cuff muscle atrophy (MA) and fatty infiltration (FI) with glenoid morphology.
Category: Trauma; Basic Sciences/Biologics Introduction/Purpose: A variable pitch locking screw is intended to provide interfragmentary compression combined with fixed angle stability of plate constructs. The objective this study was compare screws standard in bicortical fixation scenarios cadaver bone, by assessing: (1) and plate-bone compression; (2) construct biomechanical stability. Methods: Nine matched pairs fresh-frozen cadaveric specimens were used screws. First, associated insertion...
Dynamic compression plating is a common type of fracture fixation used to compress between bone fragments. The quality across the important for postoperative stability and primary healing. Compression may be affected by surgical variations in plate prebend, screw location, torque, gap, implant material. Computational modeling provides tool systematically examining these factors, visualizing mechanisms involved. purpose this study was develop finite element model dynamic that includes...