A5104831163- Synthesis and biological activity
- Crystal structures of chemical compounds
- Metal complexes synthesis and properties
- Synthesis and Characterization of Heterocyclic Compounds
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Phenothiazines and Benzothiazines Synthesis and Activities
- Analytical Methods in Pharmaceuticals
- Quinazolinone synthesis and applications
- Polysaccharides Composition and Applications
- Polysaccharides and Plant Cell Walls
- Nanoparticles: synthesis and applications
- Drug Solubulity and Delivery Systems
- Antibiotics Pharmacokinetics and Efficacy
- Synthesis and Reactions of Organic Compounds
- Thermal and Kinetic Analysis
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Crystallography and molecular interactions
- Analytical Chemistry and Chromatography
- biodegradable polymer synthesis and properties
- Computational Drug Discovery Methods
- Inorganic and Organometallic Chemistry
- Nanoparticle-Based Drug Delivery
- Drug Transport and Resistance Mechanisms
- RNA Interference and Gene Delivery
Forman Christian College
2016-2025
Albany College of Pharmacy and Health Sciences
2021
Sir Syed University of Engineering and Technology
2017
College of Medical Sciences
2017
Government College University, Lahore
2008-2016
University of Windsor
2013
University of Sargodha
2005-2008
Pakistan Army
2002
Scientific Services
2000
Pakistan Atomic Energy Commission
1990-1992
Hemicelluloses are biopolymers with versatile properties for biomedical applications. Herein, hemicellulose (arabinoxylan)-based antibacterial film dressings were prepared and characterized. Arabinoxylan was isolated from psyllium husk. Blank gentamicin-loaded films by the solvent cast method using glycerol as plasticizer. The appropriate composition of obtained varying amounts arabinoxylan, glycerol, gentamicin. found to be transparent, smooth, bubble-free, flexible, easily peelable 2% 3%...
A series of 15 previously reported N(4)-substituted isatin-3-thiosemicarbazones 3a-o has been screened for cytotoxic, antibacterial, antifungal and urease inhibitory activities. Compounds 3b, 3e 3n proved to be active in cytotoxicity assay; exhibited a high degree cytotoxic activity (LD(50) = 1.10 x 10(-5) M). Compound 3h significant antibacterial against B. subtilis, whereas compounds 3a, 3k 3l displayed one or more fungal strains i.e. T. longifusus, A. flavus M. canis. In human enzyme...
Introduction: Non-steroidal anti-inflammatory drugs are associated with severe gastrointestinal irritation upon prolonged use, largely due to their carboxylic (-- COOH) functional group. Aim: To address this issue, we aimed synthesize diclofenac conjugates glucosamine and chitosan, converting the -COOH group into an amide (-CONH-) via a mechanochemical, environmentally friendly method. Method: In study, acid was first converted its chloride using thionyl under mechanochemical conditions...
Modern dressings should provide for local delivery of antibiotics and protect the wound from bacterial infection, dehydration environmental factors to achieve optimal healing. The can reduce adverse effects resistance challenges. In this study, we fabricated film composed arabinoxylan (AX) Plantago ovata seed husks carboxymethylcellulose (CMC) by a solvent cast method antibiotic amikacin (AMK). To determine suitability prepared AX-CMC composite films as drug materials, their physical,...
Mononuclear and binuclear transition metal [Co(II), Cu(II), Ni(II) Zn(II)] acetylsalicylates of the type [M(L)2], [M(L)2Cl2] [(M)2(L)4] have been prepared characterized on basis their physical, spectral analytical data. The complexes investigated in an vivo animal model for anti-inflammatory activity show a better effect more potent action than acetylsalicylic acid.
Sixty-three patients with rheumatoid arthritis were randomly divided into 3 groups, and treated either sodium aurothiomalate (Myocrisin), auranofin, or placebo. Gold levels in whole blood, plasma, haemolysate measured serially along clinical laboratory parameters of efficacy. Auranofin produced a higher ratio to plasma gold than Myocrisin, it appears that the affinity red cell for is reduced during therapy auranofin. did not correlate changes pain score, erythrocyte sedimentation rate,...
The mechanochemical synthesis and characterization of a zinc complex with famotidine is described. was characterized by microanalysis number spectroscopic techniques. M:L dihydrate type. Derivatization appears to enhance the activity drug inhibiting growth Helicobacter pylori (two reference 34 clinical isolates). inhibited H. in an MIC range 1-8 microg mL(-1). anti-H. zinc-famotidine against antibiotic-resistant strains nearly comparable that antibiotic-susceptible strains. found be far less...
Copper(II) and zinc(II) complexes of Schiff bases obtained by condensation amoxicillin cephalexin with salicylaldehyde/pyridoxal were prepared characterized microanalytical, thermogravimetric, magnetic spectroscopic data. All the found to be six-coordinate containing two water molecules. The electron paramagnetic resonance spectral lines exhibited rhombic distortion from axial symmetry, g|| > g⟂ ge, in copper(II) complexes. geometry appears octahedral. compounds under investigation showed...
In this article, we describe a simple and new method for the synthesis of some N4-substituted isatin-3-thiosemicarbazones based on reactions common intermediate, methyl 2-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-1-hydrazinecarbodithioate, prepared by condensing isatin with 1-hydrazinecarbodithioate, readily available amines in essentially one-step reaction. The synthesized thiosemicarbazones were fully characterized their physical, analytical, spectral (IR, 1H-NMR, EIMS) data.
Copper(II) and zinc(II) complexes of cephalexin have been prepared characterized by microanalysis thermogravimetric, magnetic spectroscopic analysis. The were found to be five-coordinate, monohydrate, ML2 type. electron paramagnetic resonance spectral lines revealed rhombic distortion from axial symmetry, with g(parallel) > g(perpendicular) g(e), in the elongated-tetragonal copper(II) complex. geometry complex seems square-pyramidal. On complexation copper zinc antimicrobial activity...
A new series of six chromone-derived compounds and their Cu(II) complexes have been synthesized characterized by physical, spectral analytical data. The ligands were screened for in vitro antibacterial activity against four Gram-negative (Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Shigella flexneri) two Gram-positive (Bacillus subtilis, Staphylococcus aureus) bacterial strains agar-well diffusion method. found to exhibit either no or low-to-moderate activities one more...