A5011294440- Spaceflight effects on biology
- High Altitude and Hypoxia
- Musculoskeletal pain and rehabilitation
- Cardiovascular and Diving-Related Complications
- Cardiovascular and exercise physiology
- Sports Performance and Training
- Effects of Vibration on Health
- Balance, Gait, and Falls Prevention
- Occupational Health and Performance
- Muscle activation and electromyography studies
- Space Exploration and Technology
- Muscle metabolism and nutrition
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Health and Disease Prevention
- Ergonomics and Musculoskeletal Disorders
- Motor Control and Adaptation
- Scoliosis diagnosis and treatment
- Muscle Physiology and Disorders
- Noise Effects and Management
- Sports injuries and prevention
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Barrier Structure and Function Studies
- Lower Extremity Biomechanics and Pathologies
- Prosthetics and Rehabilitation Robotics
Boeing (Spain)
2025
European Astronaut Centre
2015-2024
Northumbria University
2021-2024
Otto-von-Guericke University Magdeburg
2016-2022
Stadtwerke Köln (Germany)
2021
International Space University
2021
University Hospital Magdeburg
2012-2020
Boeing (Germany)
2020
Karlsruhe Institute of Technology
2019
Philipps University of Marburg
2018
Many robotic applications, such as milling, gluing, or high precision measurements, require the precise following of a predefined geometric path. We investigate real-time feasible implementation model predictive path-following control for an industrial robot. consider constrained output path with and without reference speed assignment. Finally, we present results proposed controller on KUKA LWR IV
To counteract microgravity (µG)-induced adaptation, European Space Agency (ESA) astronauts on long-duration missions (LDMs) to the International Station (ISS) perform a daily physical exercise countermeasure program. Since first ESA crewmember completed an LDM in 2006, program has strived provide efficient protection against decreases body mass, muscle strength, bone and aerobic capacity within operational constraints of ISS environment changing availability on-board devices. The purpose...
Inactivating mutations of the NF-κB essential modulator (NEMO), a key component signaling, cause genetic disease incontinentia pigmenti (IP). This leads to severe neurological symptoms, but mechanisms underlying brain involvement were unclear. Here, we show that selectively deleting Nemo or upstream kinase Tak1 in endothelial cells resulted death cells, rarefaction microvessels, cerebral hypoperfusion, disrupted blood–brain barrier (BBB), and epileptic seizures. TAK1 NEMO protected BBB by...
Exercise in space has evolved from rudimental testing into the multi-modal countermeasure (CM) program used on International Space Station (ISS). However, with constraints of future exploration missions, replicating this will be a significant challenge. Recent ISS data suggest that crew now experience only relatively moderate levels microgravity (μG)-induced adaptation, although variation remains, some displaying marked changes despite time/effort investment. This suggests efficacy exercise...
<b>Objective:</b> To evaluate whether left ventricular ejection time indexed for heart rate (left index (LVETI)) and arterial wave reflections (augmented pressure (AP)) are increased in patients with diastolic dysfunction (DD). <b>Design:</b> Prospective observational study. <b>Setting:</b> University teaching hospital providing primary tertiary care. <b>Subjects:</b> 235 consecutive undergoing catheterisation were categorised as having definite DD, possible DD or no (controls) on the basis...
Abstract A systematic review of literature was conducted to evaluate the effectiveness passive countermeasures in ameliorating cardiopulmonary and musculoskeletal effects gravitational unloading on humans during spaceflight. This is third a series being by European Space Agency physiologic deconditioning With future long-duration space missions horizon, it critical understand existing promote astronaut health improve probability mission success. An updated search for studies examining 2021...
<title>Abstract</title> Computer simulations of structural mechanics, like Finite Element Method (FEM) models or multibody systems, have been a standard tool for engineers long time; nevertheless, those kinds are typically performed offline, i.e., there is no possibility to interact with the simulation before it completed. Especially changing parameters boundary conditions, however, being able in real-time online might be advantageous. Instead building visualization and user input components...
Moon and Mars are considered to be future targets for human space explorations. The gravity level on the amount 16% 38%, respectively, of Earth’s gravity. Mechanical loading during anticipated habitual activities in these hypogravity environments will most likely not sufficient maintain physiological integrity astronauts unless additional exercise countermeasures performed. Current microgravity appear attenuate but prevent ‘space deconditioning’. However, plyometric exercises (hopping whole...
BackgroundPostoperative atrial fibrillation (AF) occurs in up to 50% of cardiac surgery patients and represents the most common postoperative arrhythmic complication. A reduction length hospital stay is a desirable goal preventive strategies AF. The aim present investigation was determine whether prolonged associated with AF after attributable arrhythmia itself or baseline characteristics who develop
Exposure to axial unloading induces adaptations in paraspinal muscles, as shown after spaceflights. This study investigated whether daily exposure artificial gravity (AG) mitigated lumbar spine flattening and muscle atrophy associated with 60-day head-down tilt (HDT) bed rest (Earth-based space analog). Twenty-four healthy individuals participated the study: 8 received 30-min continuous AG; 6 × 5-min AG interspersed periods; no (control group). Magnetic resonance imaging (MRI) of lumbopelvic...
The validity of venous ultrasound (V-US) for the diagnosis deep vein thrombosis (DVT) during spaceflight is unknown and difficult to establish in diagnostic accuracy management studies this context. We performed a systematic review use V-US upper-body system identify microgravity-related changes effect interventions reverse them, assess appropriateness with terrestrial standards. An tool was developed following expert panel discussions studies, including criteria relevant crew experience,...
Summary Whole‐body vibration ( WBV ) training is commonly practiced and may enhance peripheral blood flow. Here, we investigated muscle morphology acute microcirculatory responses before after a 6‐week resistive exercise intervention without RE or with RVE simultaneous whole‐body vibrations (20 Hz, 6 mm peak‐to‐peak amplitude) in 26 healthy men randomized, controlled parallel‐design study. Total haemoglobin (t H b) tissue oxygenation index TOI were measured gastrocnemius GM near‐infrared...
This study investigated whether artificial gravity (AG), induced by short-radius centrifugation, mitigated deterioration in standing balance and anticipatory postural adjustments (APAs) of trunk muscles following 60-day head-down tilt bed rest. Twenty-four participants were allocated to one three groups: control group (n = 8); 30-min continuous AG daily intermittent 6 × 5 min 8). Before immediately after rest, was assessed four conditions: eyes open closed on both stable foam surfaces....
Summary In the light of dynamic nature habitual plantar flexor activity, we utilized an incremental isokinetic exercise test ( IIET ) to assess work‐related power deficit W o RPD as a measure for exercise‐induced muscle fatigue before and after prolonged calf unloading in relation arterial blood flow perfusion. Eleven male subjects (31 ± 6 years) wore HEPHAISTOS orthosis unilaterally 56 days. It allows ambulation while greatly reducing activity torque production. Endpoint measurements...
Summary Background The impact of whole‐body vibration ( WBV ) upon the cardiovascular system is receiving increasing attention. Despite numerous studies addressing acute effects training, very little known regarding long‐term adaptations in healthy humans. Methods A 6‐week training study, with a 70 days follow‐up was designed to compare resistive exercise or without super‐imposed vibrations. Arterial diameter, intima media thickness and flow‐mediated dilation FMD were assessed by...