A5006236353- Pancreatic function and diabetes
- Diabetes and associated disorders
- Pluripotent Stem Cells Research
- Nerve injury and regeneration
- Sphingolipid Metabolism and Signaling
- Diabetes Management and Research
- Pancreatitis Pathology and Treatment
- Neuropeptides and Animal Physiology
- Congenital heart defects research
- Auditing, Earnings Management, Governance
- Neuroscience and Neural Engineering
- Axon Guidance and Neuronal Signaling
- S100 Proteins and Annexins
- Endoplasmic Reticulum Stress and Disease
- Immune Cell Function and Interaction
- Diabetes Treatment and Management
- Cannabis and Cannabinoid Research
- Calcium signaling and nucleotide metabolism
- HER2/EGFR in Cancer Research
- scientometrics and bibliometrics research
- Regulation of Appetite and Obesity
- Advancements in Transdermal Drug Delivery
- Ion Transport and Channel Regulation
- Cell Adhesion Molecules Research
- Microtubule and mitosis dynamics
Lund University
2009-2023
University of Gothenburg
2005-2022
Stem Cell Institute
2010
Harvard University
2003-2004
Massachusetts Eye and Ear Infirmary
2003
Smith-Kettlewell Eye Research Institute
2003
Human embryonic stem cell (hESC)-derived dopamine neurons are currently moving toward clinical use for Parkinson's disease (PD). However, the timing and extent at which cell-derived functionally integrate into existing host neural circuitry after transplantation remain largely unknown. In this study, we modified rabies virus to trace afferent efferent connectivity of transplanted hESC-derived in a rat model PD report that grafted human an unexpectedly rapid extensive manner. The pattern...
Abstract Fibroblast growth factor (FGF) signaling controls axis formation during endoderm development. Studies in lower vertebrates have demonstrated that FGF2 primarily patterns the ventral foregut into liver and lung, whereas FGF4 exhibits broad anterior-posterior left-right patterning activities. Furthermore, an inductive role of dorsal pancreas has been shown. However, whether plays a similar human development remains unknown. Here, we show specifies hESC-derived definitive (DE)...
Early growth and differentiation of the pancreatic endoderm is regulated by soluble factors from mesenchyme. Previously, we demonstrated that N-cadherin-deficient mice lack a dorsal pancreas, due to critical role N-cadherin in mesenchymal cell survival. Here, show restoring cardiac circulatory function null cardiac-specific expression N-cadherin, rescues formation indicating phenotype secondary defects related cardiac/vascular function. Based on this observation, demonstrate present plasma,...
Delamination plays a pivotal role during normal development and cancer. Previous work has demonstrated that delamination epithelial cell movement within the plane of an epithelium are associated with change in cellular phenotype. However, how this positional is linked to differentiation remains unknown. Using developing mouse pancreas as model system, we show β two independent events, which controlled by Cdc42/N-WASP signaling. Specifically, expression constitutively active Cdc42 cells...
The cadherin family of cell adhesion molecules mediates adhesive interactions that are required for the formation and maintenance tissues. Previously, we demonstrated N-cadherin, which is numerous morphogenetic processes, expressed in pancreatic epithelium at E9.5, but later becomes restricted to endocrine aggregates mice. To study role N-cadherin during pancreas function generated a tissue-specific knockout early by inter-crossing N-cadherin-floxed mice with Pdx1Cre Analysis...
Highlights•MAFA controls autonomic-nervous-system-mediated insulin secretion•MAFA activates nicotinic receptor expression in mouse and human β cells•Nicotinic signaling is required for acetylcholine-mediated secretion•Polymorphisms genes affect islet diabetesSummaryMonoamine acetylcholine neurotransmitters from the autonomic nervous system (ANS) regulate secretion pancreatic islets. The molecular mechanisms controlling neurotransmitter cells their impact on diabetes development are only...
To determine which of the neurotrophins (NTs)-nerve growth factor (NGF), brain-derived neurotrophic (BDNF), neurotrophin-3 (NT3), and neurotrophin-4/5 (NT4)-and their receptors (NTrs), TrkA, TrkB, TrkC, p75, are present in adult rat lacrimal gland.RT-PCR was performed on RNA isolated from male gland, using oligonucleotides specific to each NT NTr. The presence NTr protein, determined by Western blot analysis gland homogenate or membranes. location NTs NTrs immunofluorescence histochemistry....
Precise regulation of β-cell function is crucial for maintaining blood glucose homeostasis. Pax6 an essential regulator β-cell-specific factors like insulin and Glut2. Studies in the developing eye suggest that interacts with Mitf to regulate pigment cell differentiation. Here, we show Mitf, Pax6, expressed all pancreatic endocrine cells during mouse postnatal development adult islet. A loss-of-function mutation results improved tolerance enhanced secretion but no increase mass mice. Mutant...
Vitamin A-derived retinoic acid (RA) signals are critical for the development of several organs, including pancreas. However, tissue-specific control RA synthesis in organ and cell lineage has only poorly been addressed vivo. Here, we show that retinol dehydrogenase-10 (Rdh10), a key enzyme embryonic production, important functions pancreas organogenesis endocrine differentiation. Rdh10 was expressed developing epithelium surrounding mesenchyme. null mutant mouse embryos exhibited dorsal...
Hormone secretion from pancreatic islets is essential for glucose homeostasis, and loss or dysfunction of islet cells a hallmark type 2 diabetes. Maf transcription factors are crucial establishing maintaining adult endocrine cell function. However, during pancreas development, MafB not only expressed in insulin- glucagon-producing cells, but also Neurog3+ progenitor suggesting additional functions differentiation formation. Here, we report that deficiency impairs β clustering formation,...
The purpose of this citation analysis is to understand what kind publications are cited by scholars at the School Business, Economics and Law University Gothenburg. study uses publication data from 2015 2018, analyses school's four departments their research sections. Four questions examined: type documents cited, most-cited journals, age materials, extent library provides access these materials. seeks provide a better understanding similarities differences across cultures, respond faculty...
Type 1 (T1D) and type 2 (T2D) diabetes are triggered by a combination of environmental and/or genetic factors. Maf transcription factors regulate pancreatic beta (β)-cell function, have also been implicated in the regulation immunomodulatory cytokines like interferon-β (IFNβ1). In this study, we assessed MAFA MAFB co-expression with pro-inflammatory cytokine signaling genes RNA-seq data from human islets. Interestingly, expression was strongly negatively correlated cytokine-induced (such as...
Delamination plays a pivotal role during normal development and cancer. Previous work has demonstrated that delamination epithelial cell movement within the plane of an epithelium are associated with change in cellular phenotype. However, how this positional is linked to differentiation remains unknown. Using developing mouse pancreas as model system, we show β two independent events, which controlled by Cdc42/N-WASP signaling. Specifically, expression constitutively active Cdc42 cells...