A5056624782- Ethics in Clinical Research
- Biomedical Ethics and Regulation
- BRCA gene mutations in cancer
- Global Cancer Incidence and Screening
- Axon Guidance and Neuronal Signaling
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hereditary Neurological Disorders
- Vasculitis and related conditions
- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Health, Environment, Cognitive Aging
- Intellectual Property and Patents
- Apelin-related biomedical research
- Skin and Cellular Biology Research
- Biomedical and Engineering Education
- Delphi Technique in Research
- Nutrition, Genetics, and Disease
- Law, AI, and Intellectual Property
- Ethics in medical practice
- Race, Genetics, and Society
- Health Systems, Economic Evaluations, Quality of Life
- Patient Dignity and Privacy
- Neurogenesis and neuroplasticity mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Feminist Epistemology and Gender Studies
McGill University
2013-2024
McGill Genome Centre
2013-2022
McGill University Health Centre
2021
McGill University and Génome Québec Innovation Centre
2014
Mount Sinai Hospital
2012-2013
Lunenfeld-Tanenbaum Research Institute
2012-2013
Mount Sinai Hospital
2004-2005
Centre Hospitalier de l’Université de Montréal
1998-1999
Université de Montréal
1995
Université de Sherbrooke
1993-1994
Efforts are underway to harmonise the return of individual results and incidental findings from whole genome sequencing (WGS) across research contexts countries. We reviewed international, regional national laws policies applying 20 countries identify areas convergence divergence. Discrepancies between most problematic where they cannot be reconciled through harmonisation project-level governance. Rules for apply at different levels in jurisdictions (e.g., human subjects research, biobanks,...
Consent is generally required for research and sharing rich individual-level data but presents additional ethical legal challenges where participants have diminished decision-making capacity. We formed a multi-disciplinary team to develop best practices consent in data-intensive dementia research. recommend that processes support by persons with dementia, protect them from exploitation, promote the common good. Broad designed endure beyond loss of capacity combined ongoing oversight can...
Risk-stratified screening for breast cancer (BC) is increasingly considered as a promising approach. However, its implementation challenging and needs to be acceptable women. We examined Canadian women’s attitudes towards, comfort level about, willingness take part in BC risk-stratified screening. conducted an online survey women aged 30 69 years four provinces. In total, 4293 completed the questionnaire (response rate of 63%). The majority (63.5% 72.8%) expressed favorable towards Most...
Context Biobanks are important resources which enable large-scale genomic research with human samples and data, raising significant ethical concerns about how participants' information is managed shared. Three previous studies of the Canadian public's opinion these topics have been conducted. Building on those results, an online survey representing first study public perceptions biobanking spanning all provinces was Specifically, this examined qualitative views biobank objectives, governance...
Plexins are functional receptors for Semaphorin axon guidance cues. Previous studies have established that some directly bind RACGTP and RHO. Recent work in C. elegans showed semaphorin 1 (smp-1 smp-2) plexin (plx-1)are required to prevent anterior displacement of the ray cells male tail (Fujii et al., 2002; Ginzburg 2002). We show genetically plx-1 is part same pathway as smp-1 smp-2 positioning. RAC GTPase genes mig-2 ced-10 probably function redundantly, whereas unc-73, which encodes a...
The participation of individuals who lack capacity is essential for advancing genomics research and neuroscience, but raises ethical legal challenges relating to vulnerability, consent, exclusion. Capacity differences between populations individuals, the dynamics over time, evolving consent regimes all raise uncertainty researchers, institutional review boards, policy makers. We international best practices including children decisionally vulnerable adults in health research. Research ethics...
Vulva development in C. elegans involves cell fate specification followed by a morphogenesis phase which homologous mirror image pairs within linear array of primordial vulva cells form crescent shape as they move sequentially towards midline position the array. The from opposite half vulvae fixed sequence fuse with one another at their leading tips to ring-shaped (toroidal) stacked precise alignment atop other. Here, we show that semaphorin 1a SMP-1, and its plexin receptor PLX-1, are...
Genetic stratification approaches in personalized medicine may considerably improve our ability to predict breast cancer risk for women at higher of developing cancer. Notwithstanding these advantages, concerns have been raised about the use genetic information derived processes, outside research and medical health care settings, by third parties such as insurers. Indeed, insurance applicants are asked consent insurers accessing their (implicitly including genetic) verify or determine...
Graded distributions of netrin and semaphorin guidance cues convey instructive polarity information to migrating cells growth cones, but also have permissive (i.e. non-polarity determining) functions in mammalian development repair. The these are largely uncharacterised at a molecular level. We found previously that UNC-6 (netrin) signals permissively through UNC-40 (DCC) UNC-5 receptors prevent anterior displacement the ray 1 sensillum C. elegans male tail. UNC-6/UNC-40 signalling parallel...
Strategy, Management and Health Policy Enabling Technology, Genomics, Proteomics Preclinical Research Postmarketing Phase IV Healthcare-related bioinformatics databases are increasingly offering the possibility to maintain, organize, distribute DNA sequencing data. Different national international institutions currently hosting such that offer researchers website platforms where they can obtain data on which perform different types of analysis. Until recently, this process remained mostly...
In June 2013, Canadian Blood Services (CBS) established the National Public Cord Bank (NPCBB) accessible to and international patients researchers. The NPCBB promotes efforts that contribute research improved clinical care by making units not suitable for banking or transplantation available research. context of CBS, this article will focus on practical tools (e.g., consent protocols) developed optimize umbilical cord blood (UCB) while enabling ethical provenance UCB stem cells. approach...
Netrin and semaphorin axon guidance cues have been found to function in the genesis of several mammalian organs; however, little is known about underlying molecular mechanisms involved. A genetic approach could help reveal underpinnings these mechanisms. The most anterior ray sensillum (ray 1) Caenorhabditis elegans male tail frequently displaced its normal position smp-1/semaphorin-1a plexin-1/plx-1 mutants. Here we report that UNC-6/netrin UNC-40/DCC receptor signal parallel...
Dystonia musculorum is a hereditary mouse neurodegenerative disorder that primarily affects the sensory arm of nervous system. We have recently cloned and identified candidate gene for this designated it dystonin. The sequence dystonin predicts rod-shaped cytoskeletal-associated protein with an actin-binding domain at N-terminal end hemidesmosomal (bpag1) C-terminal end. Here we show abnormal transcripts are present in neural tissues spontaneous dystonia mutant, dt 24J . further transcript...
The success of risk-stratified approaches in improving population-based breast cancer screening programs depends no small part on women’s buy-in. Fear genetic discrimination (GD) could be a potential barrier to testing uptake as risk assessment. Thus, the objective this study was twofold. First, evaluate Canadian knowledge legislative context governing GD. Second, assess their concerns about possible use levels by insurance companies or employers. We cross-sectional survey 4293 (age: 30–69)...