A5052731996- Opioid Use Disorder Treatment
- Substance Abuse Treatment and Outcomes
- Forensic Toxicology and Drug Analysis
- Cannabis and Cannabinoid Research
- Pain Management and Opioid Use
- HIV, Drug Use, Sexual Risk
- Treatment of Major Depression
- Homelessness and Social Issues
- Neurotransmitter Receptor Influence on Behavior
- Prenatal Substance Exposure Effects
- Mental Health Treatment and Access
- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Attention Deficit Hyperactivity Disorder
- Pharmaceutical Practices and Patient Outcomes
- Healthcare Decision-Making and Restraints
- Psychiatric care and mental health services
- Psychology, Coaching, and Therapy
- Diet and metabolism studies
- Migration, Health and Trauma
- Child Abuse and Trauma
- Child and Adolescent Psychosocial and Emotional Development
- Health and Medical Studies
- Bipolar Disorder and Treatment
- Digital Mental Health Interventions
University of Basel
2016-2025
Universitäre Psychiatrische Kliniken Basel
2014-2025
University of Zurich
2023
Technical University of Darmstadt
2022
Museum of Art and Design Hamburg
2022
Kantonsspital Münsterlingen
2020-2021
Universitäre Psychiatrische Dienste Bern
2021
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2018
Centre for Health Evaluation and Outcome Sciences
2016-2018
University of British Columbia
2016-2018
Childhood maltreatment has diverse, lifelong impact on morbidity and mortality. The Trauma Questionnaire (CTQ) is one of the most commonly used scales to assess quantify these experiences their impact. Curiously, despite very widespread use CTQ, scores its Minimization-Denial (MD) subscale-originally designed a positive response bias-are rarely reported. Hence, little known about this measure. If biases are either common or consequential, current practices ignoring MD scale deserve revision....
Use of microdoses for induction buprenorphine treatment with overlapping full opioid agonist use: the “Bernese method” Robert Hämmig,1 Antje Kemter,2 Johannes Strasser,2 Ulrich von Bardeleben,1 Barbara Gugger,1 Marc Walter,2 Kenneth M Dürsteler,2 Vogel2 1Division Addiction, University Psychiatric Services Bern, Switzerland; 2Division Substance and Addictive Disorders, Basel Hospital, Basel, Switzerland Background: Buprenorphine is a partial µ-opioid receptor used...
Buprenorphine/naloxone (Suboxone) is a current first-line treatment for opioid use disorder (OUD). The standard induction method of buprenorphine/naloxone requires patients to be abstinent from opioids and therefore experience withdrawal symptoms prior induction, which can barrier in starting treatment. Rapid micro-induction (micro-dosing) involves the administration small, frequent does removes need period start This study aims compare effectiveness safety rapid versus with OUD.This...
<sec> <title>BACKGROUND</title> Open-door policies are recommended to reduce coercion in psychiatric wards, but evidence integrating patient perspectives on facility openness and safety measures is limited. Traditional qualitative frameworks often lack the scope necessary fully capture these views. We hypothesized that patients would express a preference for open-door demonstrate an apprehensive stance toward closed-door with emphasis autonomy dignity their care. </sec>...
Introduction: Heroin-assisted treatment (HAT) involves the supervised administration of pharmaceutical heroin (diacetylmorphine, DAM), either injectable or oral, for individuals with severe opioid use disorder who have not achieved stabilization conventional agonist treatment. Despite its growing adoption, there is limited literature on phenomenon diversion in HAT. Diversion refers to redirecting legal prescription medications from their intended medical illegal unauthorised use. This study...
Metabotropic glutamate receptor 5 (mGluR5) is involved in cocaine reward processing and addiction. Preclinical studies suggest that blocking this inhibits self-administration seeking behavior rodents. We assessed a selective noncompetitive antagonist of mGluR5 called mavoglurant phase 2 randomized, placebo-controlled clinical trial 68 adults with use disorder. Study participants were randomly assigned 1:1 ratio to an up-titrating schedule oral twice daily up 200 mg for 98 days or placebo....
Cocaine has become one of the drugs most concern in Switzerland, being associated with a wide range medical, psychiatric and social problems. Available treatment options for cocaine dependence are rare. The study sought to compare combined prize-based contingency management (prizeCM) plus cognitive-behavioral therapy (CBT) CBT alone cocaine-dependent patients. Sixty patients participated randomized, controlled trial two conditions. participants were randomly assigned experimental group (EG;...
Heroin-assisted treatment comprises the use of diacetylmorphine (pharmaceutical heroin) for individuals with severe opioid disorder. In Switzerland, take-home doses in heroin-assisted are more strictly regulated as compared to conventional agonist treatment. light COVID-19 pandemic, Swiss Federal Council provisionally adapted its policy, allowing longer prescriptions diacetylmorphine. Before beginning only occurred exceptional circumstances and under strict criteria patient eligibility....
Data from the US indicates that methadone-maintained populations are aging, with an increase of patients aged 50 or older. European methadone is sparse. This retrospective cohort study sought to evaluate age trends and related developments in population Basel-City, Switzerland. The included between April 1, 1995 March 31, 2003. Anonymized data was taken register Basel-City. For analysis distributions, patient samples were split into four categories '20-29 years' '50 years over'....
Abstract Background and aims Opioid agonist treatment (OAT) is currently the most effective for people with opioid dependence. In countries, however, access to whole range of medications restricted. This study model distribution different OAT within a naturalistic relatively unrestricted setting (Zurich, Switzerland) over time, identify patient characteristics associated each medication. Methods We used generalized estimating equation analysis data from register Zurich Swiss heroin‐assisted...
Abstract Drug markets are dynamic systems which change based on demand, competition, legislation and revenue. Shifts that not met with immediate appropriate responses from the healthcare system can lead to public health crises tragic levels of morbidity mortality, as experienced Europe in early 1990s is case North America currently. The major feature current drug market shift towards highly potent synthetic opioids such fentanyl analogues. An additional spike stimulant use further...
Abstract Heroin dependence is a severe and chronically relapsing substance use disorder with limited treatment options. Stress known to increase craving drug-taking behavior, but it not whether the stress hormone cortisol mediates these effects or may rather reduce craving, for example, by interfering addiction memory. The aim of present study was determine administration on in heroin-dependent patients depend daily dose heroin consumption. We used double-blind, placebo-controlled,...
Heroin dependence is a chronic relapsing brain disorder, characterized by the compulsion to seek and use heroin. itself has strong potential produce subjective experiences intense euphoria, relaxation release from craving. The neurofunctional foundations of these perceived effects are not well known. In this study, we have used pharmacological magnetic resonance imaging (phMRI) in 15 heroin-dependent patients stable heroin-assisted treatment program observe steady state heroin (60 min after...
Abstract Background Heroin-assisted treatment (HAT) is effective for individuals with severe opioid use disorder (OUD) who do not respond sufficiently to other agonist treatments. It mostly offered injectable diacetylmorphine (DAM) or DAM tablets creating a barrier need the rapid onset of action but are either unable unwilling inject, primarily snort opioids. To explore another route administration, we evaluated safety and feasibility intranasal (IN) DAM. Methods This multicentre...
QUESTIONS UNDER STUDY: Suicidal behaviour is a major source of burden disease. While most studies focus on cost associated with completed suicides, data costs of, non-lethal, suicide attempts are lacking. The aim this study was to assess direct annual in Basel 2003 from health services perspective. METHODS: Retrospective cost-of-illness-study the cohort WHO/EURO-Multicentre Study Parasuicide. We extracted information two hospitals involved treatment these patients. determined overall cost,...
Abstract Heroin addiction is a severe relapsing brain disorder associated with impaired cognitive control, including deficits in attention allocation. The thalamus has high density of opiate receptors and critically involved orchestrating cortical activity during control. However, there have been no studies on how acute heroin treatment modulates thalamic activity. In cross‐over, double‐blind, vehicle‐controlled study, 29 heroin‐maintained outpatients were studied after placebo...