A5058637359- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Genetic Associations and Epidemiology
- Neural and Behavioral Psychology Studies
- Memory and Neural Mechanisms
- Epigenetics and DNA Methylation
- Long-Term Effects of COVID-19
- Neural dynamics and brain function
- Transcranial Magnetic Stimulation Studies
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Genetics and Neurodevelopmental Disorders
- Mental Health Research Topics
- Neuroscience and Neuropharmacology Research
- Motor Control and Adaptation
- Health, Environment, Cognitive Aging
- Respiratory Support and Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Intensive Care Unit Cognitive Disorders
- Genetic Syndromes and Imprinting
- Pneumothorax, Barotrauma, Emphysema
- Cognitive Abilities and Testing
- Gaze Tracking and Assistive Technology
- Birth, Development, and Health
- Family and Patient Care in Intensive Care Units
University of Basel
2014-2023
Klinikum Aschaffenburg
2020
University Psychiatric Hospital
2017
Laboratory of Molecular Genetics
2017
Goethe University Frankfurt
2009-2013
University Hospital Magdeburg
2012-2013
Otto-von-Guericke University Magdeburg
2013
Recent evidence suggests that altered expression and epigenetic modification of the glucocorticoid receptor gene (<i>NR3C1</i>) are related to risk post-traumatic stress disorder (PTSD). The underlying mechanisms, however, remain unknown. Because signaling is known regulate emotional memory processes, particularly in men, modifications <i>NR3C1</i> might affect strength traumatic memories. Here, we found increased DNA methylation at NGFI-A (nerve growth factor-induced protein A) binding site...
Positive and negative emotional events are better remembered than neutral events. Studies in animals suggest that this phenomenon depends on the influence of amygdala upon hippocampus. In humans, however, it is largely unknown how these two brain structures functionally interact whether interactions similar between positive information. Using dynamic causal modeling fMRI data 586 healthy subjects, we show strength connection from to hippocampus was rapidly robustly increased during encoding...
Emotional information is better remembered than neutral information. Extensive evidence indicates that the amygdala and its interactions with other cerebral regions play an important role in memory-enhancing effect of emotional arousal. While cerebellum has been found to be involved fear conditioning, enhancement episodic memory less clear. To address this issue, we used a whole-brain functional MRI approach 1,418 healthy participants. First, identified clusters significantly activated...
Working memory, the capacity of actively maintaining task-relevant information during a cognitive task, is heritable trait. memory deficits are characteristic for many psychiatric disorders. We performed genome-wide gene set enrichment analyses in multiple independent data sets young and aged cognitively healthy subjects (n = 2,824) large schizophrenia case-control sample 32,143). The voltage-gated cation channel activity set, consisting genes related to neuronal excitability, was robustly...
The dorsolateral prefrontal cortex (DLPFC) plays a key role in working memory. Evidence indicates that transcranial magnetic stimulation (TMS) over the DLPFC can interfere with memory performance. Here we investigated for how long continuous theta-burst (cTBS) decreases performance and whether effect of cTBS on depends load. Forty healthy young subjects received either left or sham before performing 2-, 3-back letter task. An additional 0-back condition served as non-memory-related control,...
Extensive evidence indicates that women outperform men in episodic memory tasks. Furthermore, are known to evaluate emotional stimuli as more arousing than men. Because arousal typically increases formation, the females' advantage might be pronounced for emotionally information neutral information. Here, we report behavioral data from 3398 subjects, who performed picture rating and tasks, corresponding fMRI up 696 subjects. We were interested interaction between sex valence category on...
The risk of developing posttraumatic stress disorder (PTSD) increases with the number traumatic event types experienced (trauma load) in interaction other psychobiological factors. NOTCH (neurogenic locus notch homolog proteins) signaling pathway, consisting four different trans-membrane receptor proteins (NOTCH1-4), constitutes an evolutionarily well-conserved intercellular communication pathway (involved, e.g., cell-cell interaction, inflammatory signaling, and learning processes). Its...
Abstract Increasing age is tightly linked to decreased thickness of the human neocortex. The biological mechanisms that mediate this effect are hitherto unknown. DNA methylome, as part epigenome, contributes significantly age-related phenotypic changes. Here, we identify an epigenetic signature associated with cortical ( P =3.86 × 10 −8 ) and memory performance in 533 healthy young adults. on was replicated a sample comprising 596 participants major depressive disorder controls. mediates...
Working memory (WM) is an important endophenotype in neuropsychiatric research and its use genetic association studies thought to be a promising approach increase our understanding of psychiatric disease. As for any genetically complex trait, demonstration sufficient heritability within the specific study context prerequisite conducting that trait. Recently developed methods allow estimating trait using sets common markers from genome-wide (GWAS) data samples unrelated individuals. Here we...
Abstract Working memory (WM) is an important cognitive domain for everyday life functioning and often disturbed in neuropsychiatric disorders. Functional magnetic resonance imaging (fMRI) studies humans show that distributed brain areas typically described as fronto-parietal regions are implicated WM tasks. Based on data from a large sample of healthy young adults ( N = 1369), we applied independent component analysis (ICA) to the WM-fMRI signal identified two distinct networks were relevant...
Abstract Heroin dependence is a severe and chronically relapsing substance use disorder with limited treatment options. Stress known to increase craving drug-taking behavior, but it not whether the stress hormone cortisol mediates these effects or may rather reduce craving, for example, by interfering addiction memory. The aim of present study was determine administration on in heroin-dependent patients depend daily dose heroin consumption. We used double-blind, placebo-controlled,...
Human episodic memory performance is linked to the function of specific brain regions, including hippocampus; declines as a result increasing age; and markedly disturbed in Alzheimer disease (AD), an age-associated neurodegenerative disorder that primarily affects hippocampus. Exploring molecular underpinnings human key understanding hippocampus-dependent cognitive physiology pathophysiology.
Abstract Dysregulation of emotional arousal is observed in many psychiatric diseases such as schizophrenia, mood and anxiety disorders. The neurotrophic tyrosine kinase receptor type 2 gene ( NTRK2 ) has been associated with these Here we investigated the relation between genetic variability healthy young subjects two independent samples n 1 =1171; =707). In addition, diffusion tensor imaging (DTI) data a subgroup 342 participants were used to identify -related white-matter structure...
The identification of genes related to encoding, storage, and retrieval memories is a major interest in neuroscience. In the current study, we analyzed temporal gene expression changes neuronal mRNA pool during an olfactory long-term associative memory (LTAM) <i>Caenorhabditis elegans</i> hermaphrodites. Here, identified core set 712 (538 upregulated 174 downregulated) that follows three distinct peaks demonstrating multiple regulation waves LTAM. Compared with previously published positive...
Perception of emotional valence and memory performance vary across the menstrual cycle. However, consequences altered ovarian hormone levels due to intake hormonal contraceptives on these cognitive processes remain be established. In present study, which included 2169 healthy young females, we show that (HC) users rated pictures as more than HC-non-users outperformed non-users in terms better recall pictures. The observed association between HC-status was partially mediated by perception...
Significance Human memory is a highly heritable and complex trait that the outcome of several neurobiologically distinct mental processes, such as learning, maintenance, emotional modulation strength. Such which are not always amenable to direct observation, can be dissociated using computational models. Here we provide converging evidence linking model parameters related behavioral neuroimaging phenotypes sets biologically genes in populations healthy young elderly adults. Our findings...
In the last decade there has been an exponential increase in knowledge about genetic basis of complex human traits, including neuropsychiatric disorders. It is not clear, however, to what extent this can be used as a starting point for drug identification, one central hopes genome project. The aim present study was identify memory-modulating compounds through use information. We performed multinational collaborative study, which included assessment aversive memory--a trait posttraumatic...
Abstract Only a small proportion of what we see can later be recalled. Up to date it is unknown how far differences in visual exploration during encoding affect the strength episodic memories. Here, identified individual gaze characteristics by analyzing eye tracking data picture task performed 967 healthy subjects fMRI. We found positive correlation between fixation frequency and subsequent free recall performance. Brain imaging results showed with activations regions related vision memory,...
Abstract The probability to develop posttraumatic stress disorder (PTSD), characterized by vivid, intrusive emotional memories of the encountered traumatic events, depends - among other factors on number previous experiences (traumatic load) and individual genetic vulnerability. So far, our knowledge regarding biological underpinnings PTSD is relatively sparse. Genome-wide association studies (GWAS) followed independent replication might help discover novel, so far unknown mechanisms...