A5006051728- Functional Brain Connectivity Studies
- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Neural and Behavioral Psychology Studies
- Mental Health Research Topics
- EEG and Brain-Computer Interfaces
- Tryptophan and brain disorders
- Restraint-Related Deaths
- Health, Environment, Cognitive Aging
- Neural dynamics and brain function
- Traumatic Ocular and Foreign Body Injuries
- Child Abuse and Related Trauma
- Medical and Health Sciences Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Cognitive Abilities and Testing
- Tuberculosis Research and Epidemiology
- Identity, Memory, and Therapy
- Schizophrenia research and treatment
- Immune Response and Inflammation
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Innovation, Technology, and Society
- Autopsy Techniques and Outcomes
- Advanced Breast Cancer Therapies
- Neuroscience and Neuropharmacology Research
University of Basel
2014-2022
Auckland District Health Board
2021
International Breast Cancer Study Group
2018
University of Zurich
2014
University of Bern
2014
Emotional information is better remembered than neutral information. Extensive evidence indicates that the amygdala and its interactions with other cerebral regions play an important role in memory-enhancing effect of emotional arousal. While cerebellum has been found to be involved fear conditioning, enhancement episodic memory less clear. To address this issue, we used a whole-brain functional MRI approach 1,418 healthy participants. First, identified clusters significantly activated...
Abstract Increasing age is tightly linked to decreased thickness of the human neocortex. The biological mechanisms that mediate this effect are hitherto unknown. DNA methylome, as part epigenome, contributes significantly age-related phenotypic changes. Here, we identify an epigenetic signature associated with cortical ( P =3.86 × 10 −8 ) and memory performance in 533 healthy young adults. on was replicated a sample comprising 596 participants major depressive disorder controls. mediates...
Abstract Alterations in hippocampal volume are a known marker for first-episode psychosis (FEP) as well the clinical high-risk state. The Polygenic Schizophrenia-related Risk Score (PSRS), derived from large case–control study, indicates polygenic predisposition schizophrenia our sample. A total of 65 at-risk mental state (ARMS) and FEP patients underwent structural magnetic resonance imaging. We used automatic segmentation volumes using FSL-FIRST software an odds-ratio-weighted PSRS based...
Working memory (WM) is an important endophenotype in neuropsychiatric research and its use genetic association studies thought to be a promising approach increase our understanding of psychiatric disease. As for any genetically complex trait, demonstration sufficient heritability within the specific study context prerequisite conducting that trait. Recently developed methods allow estimating trait using sets common markers from genome-wide (GWAS) data samples unrelated individuals. Here we...
Abstract Working memory (WM) is an important cognitive domain for everyday life functioning and often disturbed in neuropsychiatric disorders. Functional magnetic resonance imaging (fMRI) studies humans show that distributed brain areas typically described as fronto-parietal regions are implicated WM tasks. Based on data from a large sample of healthy young adults ( N = 1369), we applied independent component analysis (ICA) to the WM-fMRI signal identified two distinct networks were relevant...
Abstract The amygdala is critically involved in emotional processing, including fear responses, and shows hyperactivity anxiety disorders. Previous research healthy participants has indicated that activity down-regulated by cognitively demanding tasks engage the PFC. It unknown, however, if such an acute down-regulation of might correlate with reduced anxious participants. In fMRI study 43 (11 men) snakes, we found when visual stimuli were processed under high cognitive load, irrespective...
DNA methylation represents an important link between structural genetic variation and complex phenotypes. The study of genome-wide CpG its relation to traits relevant psychiatry has become increasingly important. Here, we analyzed quality metrics 394,043 sites in two samples 568 319 mentally healthy young adults. For 25% all CpGs observed medium large common epigenetic variation. These were overrepresented open sea shore regions, as well intergenic regions. They also showed a strong...
Background: Reductions in the volume of brain white matter are a common feature schizophrenia and bipolar disorder while association between polygenic schizophrenia-related risk is unclear. To look at intermediate state health full-blown disorder, we investigated this aspect groups patients before after onset psychosis. Methods: On 3 Tesla scanner, total regional volumes were by structural magnetic resonance imaging (MRI) following groups: 37 at-risk mental (ARMS), including 30 with no...
Encoding and retrieval of emotionally arousing stimuli depend on the activation multiple interconnected brain regions, with people showing differences in their individual strength emotional perception recollection. Understanding association between these regions behavioral outcome might therefore have important clinical implications as dysfunctional memory processes are characteristic many psychiatric disorders. Based fMRI data collected from healthy young adults (N = 1'385), we investigated...
Diabetes mellitus (DM) triples a person's risk of active tuberculosis (TB) and is associated with increased mortality. It unclear whether diabetes status and/or the renal dysfunction poor TB outcomes in New Zealand, which has high screening.To characterise population TB-DM TB-alone to assess effect function on hospitalisation mortality.Clinical records from all adult patients diagnosed Auckland over 6-year period (2010-2015) were reviewed. Baseline demographics, clinical presentation...
Abstract BACKGROUND: The phase III IBCSG 23-01 multicenter, randomized, non-inferiority trial compared disease-free survival (DFS) in breast cancer patients with one or more micrometastatic (≤2 mm) sentinel nodes (SNs) randomized to either axillary dissection (AD) no (no-AD). Results after 5 years showed difference DFS between the arms. Here we report results a median follow-up of 9.8 years. METHODS: Eligible had cancers pathological diameter ≤5 cm and foci, including isolated tumor cells,...
Studies assessing the existence and magnitude of epistatic effects on complex human traits provide inconclusive results. The study such is complicated by considerable increase in computational burden, model complexity, uncertainty, which concert decrease stability. An additional source introducing significant uncertainty with regard to detection robust epistasis biological distance between genetic variation trait under study. Here we studied CpG methylation, a genetically molecular that...
Recognition memory is an essential ability for functioning in everyday life. Establishing robust brain networks linked to recognition performance can help understand the neural basis of itself and interindividual differences performance. We analysed behavioural whole-brain fMRI data from 1′410 healthy young adults during testing phase a picture-recognition task. Using independent component analysis (ICA), we decomposed contrast previously seen vs. new (old-new) pictures into activity. This...