A5012396675- Cardiac Health and Mental Health
- Functional Brain Connectivity Studies
- Heart Rate Variability and Autonomic Control
- Inflammatory Bowel Disease
- Genetic Associations and Epidemiology
- Microscopic Colitis
- Cardiovascular and exercise physiology
- Heart Failure Treatment and Management
- EEG and Brain-Computer Interfaces
- Cardiac Imaging and Diagnostics
- Neural and Behavioral Psychology Studies
- Transcranial Magnetic Stimulation Studies
- Healthcare professionals’ stress and burnout
- Endometriosis Research and Treatment
- Stress and Burnout Research
- Psychosomatic Disorders and Their Treatments
- Health, psychology, and well-being
- Receptor Mechanisms and Signaling
- Cognitive Abilities and Testing
- Stress Responses and Cortisol
- COVID-19 and Mental Health
- Optimism, Hope, and Well-being
- Tryptophan and brain disorders
- Posttraumatic Stress Disorder Research
- Nail Diseases and Treatments
University Hospital of Zurich
2019-2024
University of Zurich
2019-2024
Oxfam
2021
John Wiley & Sons (United States)
2021
Hudson Institute
2021
John Wiley & Sons (United Kingdom)
2021
University of Basel
2010-2019
University Hospital of Basel
2017
Laboratory of Molecular Genetics
2013
Working memory, the capacity of actively maintaining task-relevant information during a cognitive task, is heritable trait. memory deficits are characteristic for many psychiatric disorders. We performed genome-wide gene set enrichment analyses in multiple independent data sets young and aged cognitively healthy subjects (n = 2,824) large schizophrenia case-control sample 32,143). The voltage-gated cation channel activity set, consisting genes related to neuronal excitability, was robustly...
The dorsolateral prefrontal cortex (DLPFC) plays a key role in working memory. Evidence indicates that transcranial magnetic stimulation (TMS) over the DLPFC can interfere with memory performance. Here we investigated for how long continuous theta-burst (cTBS) decreases performance and whether effect of cTBS on depends load. Forty healthy young subjects received either left or sham before performing 2-, 3-back letter task. An additional 0-back condition served as non-memory-related control,...
Extensive evidence indicates that women outperform men in episodic memory tasks. Furthermore, are known to evaluate emotional stimuli as more arousing than men. Because arousal typically increases formation, the females' advantage might be pronounced for emotionally information neutral information. Here, we report behavioral data from 3398 subjects, who performed picture rating and tasks, corresponding fMRI up 696 subjects. We were interested interaction between sex valence category on...
Background: Individuals with a high prevalence of child maltreatment, e.g. those borderline personality disorder, tend to see neutral facial expressions as negative.Objective: Our aim was assess whether this bias is present in individuals posttraumatic stress disorder (PTSD) and it linked maltreatment.Methods: Thirty-nine PTSD participants, 44 traumatized 35 non-traumatized healthy controls watched 300 one-second movies showing 30 270 emotional expressions, indicated they interpreted each or...
Inflammatory bowel disease (IBD) patients are at high risk for depression, and depression has been shown to affect course. We examined interrelations between genetic factors IBD flares.In 1973 (1137 Crohn's disease, 836 ulcerative colitis) of the Swiss Cohort Study (SIBDCS), depressive status (hospital anxiety subscale HADS-D ≥11) was assessed on a yearly basis. investigated impact IBD-relevant clinical outcomes in Cox proportional hazards models. used active (CDAI ≥150 or MTWAI ≥10) 2...
Abstract Working memory (WM) is an important cognitive domain for everyday life functioning and often disturbed in neuropsychiatric disorders. Functional magnetic resonance imaging (fMRI) studies humans show that distributed brain areas typically described as fronto-parietal regions are implicated WM tasks. Based on data from a large sample of healthy young adults ( N = 1369), we applied independent component analysis (ICA) to the WM-fMRI signal identified two distinct networks were relevant...
Summary Background Inflammatory bowel disease (IBD) can be exacerbated by stress and depression. Type D personality, characterised high negative affectivity social inhibition, represents a vulnerability towards stressors is associated with adverse outcomes in coronary heart disease. Aims To assess the prevalence of personality IBD patients investigate potential associations course. Methods We tested for between ( Scale‐14 ), depressive symptoms Hospital Anxiety Depression Scale's depression...
Human episodic memory performance is linked to the function of specific brain regions, including hippocampus; declines as a result increasing age; and markedly disturbed in Alzheimer disease (AD), an age-associated neurodegenerative disorder that primarily affects hippocampus. Exploring molecular underpinnings human key understanding hippocampus-dependent cognitive physiology pathophysiology.
Cutaneous peripheral T-cell lymphoma, not otherwise specified (PTL NOS) is an aggressive, but poorly characterized neoplasm.The European Organization for Research and Treatment of Cancer cutaneous lymphoma taskforce (EORTC CLTF) investigated 33 biopsies 30 patients with primary PTL NOS to analyse their clinical, histological, immunophenotypic features outcome.Retrospective analysis clinical data histopathological by expert panel.Cutaneous manifested clinically either solitary or disseminated...
The genetic basis of phenotypic variation can be partially explained by the presence copy-number variations (CNVs). Currently available methods for CNV assessment include high-density single-nucleotide polymorphism (SNP) microarrays that have become an indispensable tool in genome-wide association studies (GWAS). However, insufficient concordance rates between different call cautious interpretation results from CNV-based studies. Here we provide a cross-population, microarray-based map...
In the last decade there has been an exponential increase in knowledge about genetic basis of complex human traits, including neuropsychiatric disorders. It is not clear, however, to what extent this can be used as a starting point for drug identification, one central hopes genome project. The aim present study was identify memory-modulating compounds through use information. We performed multinational collaborative study, which included assessment aversive memory--a trait posttraumatic...
Olfactory decline is a frequent and early non-motor symptom in Parkinson's disease (PD) which increasingly used for diagnostic purposes. Another appearing sign of PD consists EEG alterations. The combination olfactory assessment may improve the identification patients with stages PD. We hypothesized that capacity would be correlated alterations motor cognitive impairment patients. To our knowledge, mutual influence both markers – decrease changes was not studied before. assessed function...
Cardiac rehabilitation (CR) is a cornerstone of secondary prevention that improves cardiovascular outcomes. However, the determinants treatment success are poorly understood.We investigated associations health-related quality life (HRQoL), sex, age, employment status and housing situation with improvement in exercise capacity throughout CR.We analyzed data from 392 CR outpatients (81% men 19% women). Exercise at baseline upon completion program was measured 6-minute walk distance (6MWD)....
Despite the current progress in high-throughput, dense genome scans, a major portion of complex traits' heritability still remains unexplained, phenomenon commonly termed "missing heritability." The negligence analytical approaches accounting for gene-gene interaction effects, such as statistical epistasis, is probably central to this phenomenon. Here we performed comprehensive two-way SNP analysis human episodic memory, which heritable trait, and focused on 120 genes known show...
Cardiac rehabilitation (CR) not only improves cardiovascular outcomes, but also health-related quality of life (HRQOL). Unfortunately, CR is still underutilized, especially among women and older patients. Aim this study was to highlight age- sex-specific effects inpatient on HRQOL. From 2012 2018, 18 459 patients were prospectively assessed in six Swiss clinics. Of these, we retrospectively analysed a final sample 8286 with mean (standard deviation) age 67.8 (11.3) men 72.2 women. HRQOL...
Abstract Background Bleedings are frequent and dreaded complications in heart failure patients with ventricular assist devices (VAD). Serotonin reuptake inhibitor (SRI) antidepressants widely used to treat depression these patients, though they attributed an increased risk of bleeding due their modification hemostasis. Evidence on VAD under SRI medication is scarce limited. We therefore aimed assess if use associated elevated this particularly vulnerable population. Methods analyzed the...
There is a high prevalence of job burnout in physicians, impacting both the professional and personal levels. This study aimed to investigate whether physicians with show specific pathological traits facets their personalities compared healthy controls, according dimensional personality models ICD-11 DSM-5. The role perceived stress, anxiety, depression were exploratively investigated regarding group differences. Male (n = 60) recruited into two groups (burnout vs. healthy). Personality...
Abstract Introduction Cardiovascular diseases (CVD) represent the world’s leading cause of death. Health-related quality life (HRQoL) is a widely applied concept patients’ perceived health and directly linked to CVD morbidity, mortality, re-hospitalization rates. Cardiac rehabilitation (CR) improves both cardiovascular outcomes HRQoL. Regrettably, CR still underutilized, especially in subgroups like women elderly patients. The aim our study was investigate predictive potential sex age on...
Background: Low health-related quality of life (HRQoL) is associated with adverse cardiovascular outcomes in coronary heart disease (CHD) patients. Cardiac rehabilitation (CR) improves HRQoL; however, evidence on long-term HRQoL changes after CR, and their predictors, missing. Methods: A total 153 patients complete data the short-form (SF)-36 Health Survey at CR entry, discharge follow-up were included. Using linear mixed-effects regression models for repeated time measurements, we examined...
Abstract Background The bidirectional “gut-brain axis” has been implicated in the pathogenesis of inflammatory bowel diseases (IBD). While influence stress and depressive symptoms on IBD is well-characterized, role personality remains insufficiently investigated. Methods Personality was assessed 1154 Swiss cohort study (SIBDCS) patients via NEO-Five-Factor Inventory (NEO-FFI) as well 2600 participants population-based CoLaus¦PsyCoLaus (NEO-FFI-revised). NEO-FFI subcomponents activity,...
Cardiac rehabilitation (CR), a key component of secondary prevention in cardiac patients, contributes fundamentally to improved cardiovascular health outcomes. Health-related quality life (HRQOL) represents widely employed outcome measure CR, yet, its predictive properties on exercise capacity change during CR are poorly understood. Aim this study was examine the association between baseline HRQOL and subdomains improvement CR.Study participants were 13,717 inpatients six Swiss clinics from...