A5056640201- Connexins and lens biology
- Wnt/β-catenin signaling in development and cancer
- Aquaculture disease management and microbiota
- Bone Tissue Engineering Materials
- Physiological and biochemical adaptations
- Agricultural Productivity and Crop Improvement
- Heat shock proteins research
- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Bioinformatics and Genomic Networks
- RNA Research and Splicing
- Neurobiology and Insect Physiology Research
- Dental Implant Techniques and Outcomes
- Cancer Genomics and Diagnostics
- Cell Image Analysis Techniques
- RNA regulation and disease
- Botanical Research and Chemistry
- Metal and Thin Film Mechanics
- Cancer-related molecular mechanisms research
- Fungal and yeast genetics research
- Protein Structure and Dynamics
ShanghaiTech University
2023-2024
University of Toronto
2000-2017
Birkbeck, University of London
2000
Abstract The ten Frizzled receptors (FZDs) are essential in Wnt signaling and play important roles embryonic development tumorigenesis. Among these, FZD6 is closely associated with lens development. Understanding FZD activation mechanism key to unlock these emerging targets. Here we present the cryo-EM structures of FZD3 which known relay non-canonical planar cell polarity (PCP) pathways as well FZD1 their G protein-coupled states apo inactive states, respectively. Comparison three...
The freshwater snail Lymnaea stagnalis (L. stagnalis) has served as a successful model for studies in the field of Neuroscience. However, serious drawback molecular analysis nervous system L. been lack large-scale genomic or neuronal transcriptome information, thereby limiting use this unique model.In study, we report 7,712 distinct EST sequences (median length: 847 nucleotides) normalized central (CNS) cDNA library, resulting largest collection data currently available. Approximately 42%...
Micro RNAs (miRNAs) are a class of small regulatory RNAs, which posttranscriptionally repress protein production the targeted messenger (mRNAs). Accumulating evidence has suggested lineage-specific miRNAs have contributed to characteristics. However, birth and death these miRNAs, particularly in primates, largely remain unexplored. We herein characterized evolutionary history newly discovered miRNA cluster on primate X-chromosome, spanning ∼33-kb region human Xq27.3. The consists six...
About one-fifth of the genes in budding yeast are essential for haploid viability and cannot be functionally assessed using standard genetic approaches such as gene deletion. To facilitate analysis genes, we others have assembled collections strains expressing temperature-sensitive (ts) alleles genes. explore phenotypes caused by mutation used a panel genetically engineered fluorescent markers to morphology cells ts strain collection high-throughput microscopy. Here, describe design...
Plasma spray deposition of hydroxyapatite (HA) coatings is a well established commercial process. When deposited on metallic substrates, these have been shown to promote bone fixation and osteconductivity. A concern with current the formation relatively large debris particles during resorption. The size related particle powder injected into plasma use solution precursors or dispersions fine powders as feedstock for spraying has produce submicron/nanocrystalline structured from inexpensive...
Abstract The ten Frizzled receptors (FZDs) are essential in Wnt signaling and play important roles embryonic development tumorigenesis. Among these, FZD6 is closely associated with lens development. Understanding FZD activation mechanism key to unlock these emerging targets. Here we present the cryo-EM structures of FZD3 which known relay non-canonical Wnt-PCP (planar cell polarity) pathways as well FZD1 their G protein-coupled (active) protein-free (inactive) states, respectively....
Conference Abstract| October 01 2000 The biochemical activities of the aggregate formed by linear gramicidin in an aqueous environment V. K. Booth; Booth 1School Biosciences, University Birmingham, Birmingham B15 2TT, UK Search for other works this author on: This Site PubMed Google Scholar D. G. Flint; Flint F. White; White 2Department Physics, Guelph, Canada R. Hallett; Hallett Z. Zhang; Zhang 3Department Chemistry, Toronto, Canada; 4 Department Crystallography, Birkbeck College, London,...