Kefan Wu

ORCID: 0000-0002-3108-0790
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About
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Research Areas
  • Luminescence Properties of Advanced Materials
  • Nanoplatforms for cancer theranostics
  • Radiation Detection and Scintillator Technologies
  • Perovskite Materials and Applications
  • Atomic and Subatomic Physics Research
  • Advanced Sensor and Energy Harvesting Materials
  • Advanced Materials and Mechanics
  • Photoacoustic and Ultrasonic Imaging
  • Photodynamic Therapy Research Studies
  • Hydrogels: synthesis, properties, applications
  • Soft Robotics and Applications
  • Neuroscience and Neuropharmacology Research
  • Micro and Nano Robotics
  • Covalent Organic Framework Applications
  • CO2 Reduction Techniques and Catalysts
  • Bee Products Chemical Analysis
  • Advanced Combustion Engine Technologies
  • Luminescence and Fluorescent Materials
  • Medical Imaging Techniques and Applications
  • Medicinal Plant Research
  • Biochemical effects in animals
  • Click Chemistry and Applications
  • Innovative Energy Harvesting Technologies
  • Ocular Oncology and Treatments
  • Topological Materials and Phenomena

University of Amsterdam
2021-2025

Renmin Hospital of Wuhan University
2023-2025

Wuhan University
2023-2025

Macau University of Science and Technology
2025

Institute of Physics
2024

University of Chinese Academy of Sciences
2024

Changchun Institute of Optics, Fine Mechanics and Physics
2023

Huazhong University of Science and Technology
2022-2023

Anhui University
2020-2023

Wuhan Institute of Physics and Mathematics
2023

Abstract With the rapid development of micro‐energy harvesting technology, noise has great potential as a new type source by developing high‐performance acoustic energy harvester (AEH). Nevertheless, challenges from are low density, multi‐frequency mixed sound, and unstable sound pressure. Piezoelectric‐based AEHs proposed solution, but most reported devices need to work at certain frequency very high pressure, exhibit disadvantages being bulky heavy when using an extra sound‐pressure...

10.1002/aelm.202300348 article EN cc-by Advanced Electronic Materials 2023-07-02

Simultaneous photothermal ablation of multiple tumors is limited by unpredictable photo-induced apoptosis, caused individual intratumoral differences. Here, a multi-channel lanthanide nanocomposite was used to achieve tailored synergistic treatment subcutaneous orthotopic under non-uniform whole-body infrared irradiation prescription. The reduces glutathione simultaneously activating the fluorescence and channels. provides information on different tumors, allowing customized prescriptions be...

10.1002/anie.202303570 article EN cc-by Angewandte Chemie International Edition 2023-04-26

Abstract As a promising material, ionogels have garnered increasing interest in various applications including flexible electronics and energy storage. However, most existing suffer from poor mechanical properties. Herein, an effective universal strategy is reported to toughen by freezing the polymer network via design. proof of concept, ionogel readily prepared copolymerization isobornyl acrylate (IBA) ethoxyethoxyethyl (CBA) presence ionic liquid, resulting bicontinuous phase‐separated...

10.1002/smll.202500477 article EN Small 2025-02-18

Background/Objectives: Lactate, classically considered a metabolic byproduct of anaerobic glycolysis, is implicated in ischemic acidosis and neuronal injury. The recent evidence highlights its potential role sustaining networks neuroprotection. This study investigates lactate’s compensatory mechanisms brain injury by analyzing post-ischemic enrichments inter-regional metabolite correlations. Methods: Dynamic profiling was conducted using 13C-labeled glucose combined with 1H-13C NMR...

10.3390/biomedicines13040789 article EN cc-by Biomedicines 2025-03-24

Abstract Achieving accurate and real‐time ratiometric luminescence thermometry is one important application of lanthanide‐based upconversion materials. Traditional sensoring mechanism relies on the thermal coupling between two closely linked energy levels (following Boltzmann's law), which locks ability these sensors to detection relatively high temperatures (usually above 77 K). In this work, limitation broken by establishing a new type thermometer with lanthanide high‐level‐doping...

10.1002/lpor.202402222 article EN Laser & Photonics Review 2025-03-31

Relatively low efficiency is the bottleneck for application of lanthanide-doped upconversion nanoparticles (UCNPs). The high-level doping strategy realized in recent years has not improved as much expected. It argued that cross relaxation (CR) detrimental to upconversion. Here we combine theoretical simulation and spectroscopy elucidate role CR process Er

10.1002/anie.202217100 article EN cc-by-nc-nd Angewandte Chemie International Edition 2022-12-13

Nowadays, cancer poses a significant hazard to humans. Limitations in early diagnosis techniques not only result waste of healthcare resources but can even lead delays and treatment, consequently reducing cure rates. Therefore, it is crucial develop an imaging probe that provide diagnostic information precisely rapidly. Here, we used simple hydrothermal method design multimodal based on the excellent properties rare-earth ions. Calcium fluoride co-doped with ytterbium, gadolinium, neodymium (CaF

10.3390/pharmaceutics14040840 article EN cc-by Pharmaceutics 2022-04-11

Recently high doping of lanthanide ions (till 100 %) is realized unprecedentedly in nanostructured upconversion (UC) phosphors. However, oddly enough, this significant breakthrough did not result a corresponding UC enhancement at ambient temperature, which hinders the otherwise very interesting applications these materials various fields. In work, taking Er3+ -rich nanosystem as an example, we confirm unambiguously that phonon-assisted cross relaxation (CR) culprit. More importantly,...

10.1002/anie.202306585 article EN cc-by Angewandte Chemie International Edition 2023-06-24

Abstract Photoclick reactions combine the selectivity of classical click chemistry with high precision and spatiotemporal control afforded by light, finding diverse utility in surface customization, polymer conjugation, photocross‐linking, protein labeling, bioimaging. Nonetheless, UV pivotal prevailing photoclick reactions, poses issues, especially biological contexts, due to its limited tissue penetration cell‐toxic nature. Herein, a reliable versatile strategy activating...

10.1002/adfm.202306531 article EN cc-by Advanced Functional Materials 2023-09-06

Nanoplatforms consisting of an upconversion nanocore and outermost X-ray active shell for PDT enable photoswitchable UCL imaging RT&X-PDT.

10.1039/d1tc04930e article EN cc-by-nc Journal of Materials Chemistry C 2021-11-29

Here, we describe the synthesis of a novel type rare-earth-doped nanoparticles (NPs) for multimodal imaging, by combining rare-earth elements Ce, Gd and Nd in crystalline host lattice consisting CaF2 (CaF2: Gd, Nd). CaF2: NPs are small (15-20 nm), uniform shape size distribution, show good biocompatibility low immunogenicity vitro. In addition, possess excellent optical properties. produce downconversion emissions second near-infrared window (NIR-II, 1000-1700 nm) under 808 nm excitation,...

10.3390/pharmaceutics14122796 article EN cc-by Pharmaceutics 2022-12-14

When combined with diverse sensors, soft robots significantly improve their functionalities and intelligence levels. However, most of the existing sensors require complex signal analysis devices or algorithms, which severely increase complexity robot systems. Here, based on unique fluidic property liquid metal, we propose a magnet-controllable microswitch that can be well-integrated into system, e.g., gripper to help it facilely detect precisely grab objects. The consists flexible beam...

10.3390/mi13122255 article EN cc-by Micromachines 2022-12-18

Direct visualization of the states originating from electron-electron interactions is great importance for engineering surface and interfacial properties graphene-based quantum materials. For instance, rotational symmetry breaking or nematic phase inferred spectroscopic imaging has confirmed existence correlated in a wide range moiré Here, we study atomic-scale spatial distributions wave functions gate-tunable twisted double bilayer graphene by employing scanning tunneling...

10.1039/d4nr02933j article EN cc-by-nc Nanoscale 2024-01-01

Purpose: To investigate the antidepressant mechanism of action Crassifoside H (CH) from rhizomes Curculigo glabrescens (Hypoxidaceae) in chronic unpredictable mild stress (CUMS)-induced rats.Methods: CUMS-induced rat depressant model was established. Behavioral tests, viz, sucrose preference test (SPT), open field (OFT) and forced swimming (FST) were applied to assess effect CH. Enzyme linked immunosorbent assay (ELISA) used thelevels corticosterone (CORT), TNF-α IL-1β serum. Protein...

10.4314/tjpr.v19i8.18 article EN cc-by Tropical Journal of Pharmaceutical Research 2020-11-19

Abstract Simultaneous photothermal ablation of multiple tumors is limited by unpredictable photo‐induced apoptosis, caused individual intratumoral differences. Here, a multi‐channel lanthanide nanocomposite was used to achieve tailored synergistic treatment subcutaneous orthotopic under non‐uniform whole‐body infrared irradiation prescription. The reduces glutathione simultaneously activating the fluorescence and channels. provides information on different tumors, allowing customized...

10.1002/ange.202303570 article EN cc-by Angewandte Chemie 2023-04-26

Abstract Relatively low efficiency is the bottleneck for application of lanthanide‐doped upconversion nanoparticles (UCNPs). The high‐level doping strategy realized in recent years has not improved as much expected. It argued that cross relaxation (CR) detrimental to upconversion. Here we combine theoretical simulation and spectroscopy elucidate role CR process Er 3+ highly doped (HD) UCNPs. found if purposively suppressed, can be significantly improved. Specifically, demonstrate...

10.1002/ange.202217100 article EN cc-by-nc-nd Angewandte Chemie 2022-12-13

Abstract Energy crises and climate change lead to restricted standards of emission energy consumption in regular road vehicles. Combustion method, ignition time, injection time are engine development priorities. Optimal timing at 1600 rpm can save 10% on brake fuel. Perfect reduce heat loss emissions. Various approaches reducing transportation emissions were implemented. Plug-in electric vehicles hydrogen fuel cell (HFCV) eliminated because the lack charging refilling facilities. Mild hybrid...

10.1088/1742-6596/2419/1/012019 article EN Journal of Physics Conference Series 2023-01-01

Abstract Recently high doping of lanthanide ions (till 100 %) is realized unprecedentedly in nanostructured upconversion (UC) phosphors. However, oddly enough, this significant breakthrough did not result a corresponding UC enhancement at ambient temperature, which hinders the otherwise very interesting applications these materials various fields. In work, taking Er 3+ ‐rich nanosystem as an example, we confirm unambiguously that phonon‐assisted cross relaxation (CR) culprit. More...

10.1002/ange.202306585 article EN cc-by Angewandte Chemie 2023-06-24

Abstract Lactate is not only the energy substrate of neural cells, but also an important signal molecule in brain. In modern societies, disturbed circadian rhythms pose a global challenge. Therefore, exploring influence period on lactate and its metabolic kinetics essential for advancement neuroscientific research. present study, mice were infused [3- 13 C] through tail vein duration two minutes. After 30 minutes metabolism, animals sacrificed brain tissue was extracted tested. And then [ 1...

10.21203/rs.3.rs-3348739/v1 preprint EN cc-by Research Square (Research Square) 2023-09-26
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