A5101886888- Bacterial Identification and Susceptibility Testing
- Chemical synthesis and alkaloids
- Receptor Mechanisms and Signaling
- Advanced biosensing and bioanalysis techniques
- Plant Pathogens and Fungal Diseases
- Antibiotic Resistance in Bacteria
- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- Synthesis and Catalytic Reactions
- Neurotransmitter Receptor Influence on Behavior
- RNA Interference and Gene Delivery
- Enterobacteriaceae and Cronobacter Research
- Psychedelics and Drug Studies
- Quinazolinone synthesis and applications
- Advanced Drug Delivery Systems
- Pain Mechanisms and Treatments
- Educational Research and Pedagogy
- Nanopore and Nanochannel Transport Studies
- Lipid Membrane Structure and Behavior
- Traditional and Medicinal Uses of Annonaceae
- Neuroscience and Neuropharmacology Research
- Alkaloids: synthesis and pharmacology
- Plant and animal studies
- CRISPR and Genetic Engineering
- Pharmacological Effects of Natural Compounds
Korea University
2016-2020
Government of the Republic of Korea
2020
Seoul Institute
2020
Korea Institute of Science and Technology
2016-2019
Korea Institute of Brain Science
2016
Korea University of Science and Technology
2014
Seoul National University
2008
Abstract Summary: Genomes of more than 60 fungal species have been sequenced to date, yet there has no systematic approach analyze transcription factors (TFs) kingdom widely. We developed a standardized pipeline for annotating TFs in genomes. Resulting data archived new database termed the Fungal Transcription Factor Database (FTFD). In FTFD, 31 832 putative TFs, identified from 62 and 3 Oomycete species, were classified into 61 families phylogenetically analyzed. The FTFD will serve as...
We herein propose a polymeric nanovehicle system that has the ability to remarkably improve cellular uptake and transdermal delivery. Cell-penetrating peptide-patchy deformable nanovehicles were fabricated by tailored coassembly of amphiphilic poly(ethylene oxide)-block-poly(ε-caprolactone) (PEO-b-PCL), mannosylerythritol lipid (MEL), YGRKKRRQRRR-cysteamine (TAT)-linked MEL. Using X-ray diffraction, differential scanning calorimetry, nuclear magnetic resonance analyses, we revealed...
An ER-targeting, intracellular delivery approach that utilizes cell-penetrating peptide-conjugated lipid/polymer hybrid nanovehicles is proposed.
The serotonin 2C receptor subtype (5-HT2C) is an excitatory 5-HT widely distributed throughout the central nervous system. As 5-HT2C displays multiple actions on various neurotransmitter systems including glutamate, dopamine, epinephrine, and γ-aminobutyric acid (GABA), abnormalities of are associated with psychiatric diseases such as depression, schizophrenia, drug abuse, anxiety. Up to date, three kinds PET radiotracers [11C]N-methylated arylazepine (1), [11C]WAY-163909 (2),...
As a Korean endemic plant, Salix koriyanagi Kimura ex Goerz belongs to the genus L. which is largest of Salicaceae. In this study, we presented complete chloroplast genome S. 155,707 bp and has four sub-regions: 84,484 large single copy (LSC) 16,125 small (SSC) regions are separated by 27,549 inverted repeat (IR) including 130 genes (83 coding regions, 8 rRNAs, 38 tRNAs). The overall GC contents were 36.7% in LSC, SSC, IR 34.4%, 31.00%, 41.8%, respectively. A phylogenetic analysis showed...
Rapid and accurate detection of carbapenemase-producing Enterobacteriaceae (CPE) is critical for appropriate treatment infection control. We compared a rapid fluorogenic assay using carbapenem-based probe with other phenotypic assays: modified carbapenem inactivation method (mCIM), Carba NP test (CNP), carbapenemase inhibition (CIT).
Abstract Background: The cGAS-STING signaling pathway has led to significant anti-cancer innate immune responses in cancer immunotherapy. 2’3’-cGAMP binds STING and promotes the production of various pro-inflammatory cytokines such as type I interferon, which changes cold tumors hot through modulating tumor microenvironment. Therefore, activation been considered an important target for Ecto-Nucleotide Pyrophosphatase/Phosphodiesterases 1 (ENPP1), highly expressed membrane-bound enzyme cells,...
A transition‐metal‐free and regioselective synthesis of a series 2‐amino‐4‐alkoxypyrimidines is described. The S N Ar alkoxylation 2,4‐dichloropyrimidines regioselectively provided 2‐chloro‐4‐alkoxypyrimidines, which were subsequently subject to the second amination with cyclic amines in presence triethylamine at high temperature afford good overall yield.
A series of 2-amino and 2-methoxy quinoline-6-carboxamide derivatives have been synthesized their metabotropic glutamate receptor type 1 (mGluR1) antagonistic activities were evaluated in a functional cell-based assay. The compound 13c showed the highest potency with IC50 value 2.16 µm against mGluR1. Finally, vivo evaluation rat spinal nerve ligation (SNL) model exhibited weak analgesic effects regard to both mechanical allodynia cold allodynia.
Here, we describe the synthesis of disubstituted pyrimidine derivatives and their biological evaluation as selective 5-HT2C agonists. To improve selectivity for over other subtypes, synthesized two series pyrimidines with fluorophenylalkoxy groups at either 5-position or 4-position varying cyclic amines 2-position. The in vitro cell-based assay binding identified compounds 10a 10f potent Further studies on to 5-HT subtypes drug-like properties indicated that 2,4-disubstituted showed a highly...
With the new standards for “equal sign and equivalence relation” in grades 3 4 of 2022 revised mathematics curriculum, there is a need to specifically explore implement instructional practices that support relational understanding equality. In this study, we implemented three lessons emphasizing equal third grade students analyze lessons. We developed teaching methods emphasize both sameness substitution meaning based on previous research. First, teacher emphasized sameness, learned one...
2015â2016ë ì¬ì´ ë¼ì¤ì¤ ì물ìì ì¡°ì¬íë ê³¼ì ìì ë°ê²¬í ë¯¸ê¸°ë¡ ííì물ì ë³´ê³ íë¤. í¸ì¹´ì¤ì¿ ì¤ìì´ êµê°ì물ë¤ìì±ë³´ì ì§êµ¬ìì ì¼ëª©ë¨ê³¼(Melastomataceae)ì Phyllagathis tuberosa (C. Hansen) Cellinese & S. Rennerì 꼬리겨ì°ì´ì´ê³¼(Loranthaceae)ì Tolypanthus pustulatus Barlow를 ë°ê²¬íìì¼ë©°, ì´ë¤ì íêµì 기ì¤í본 ì±ì§ì§ ì¸ìë ìì§ê¹ì§ ì±ì§ë ë° ìë ì¢ ë¤ë¡, ë¼ì¤ì¤ì ë¶í¬íë...
A series of pyrimidine derivatives 4a–i were synthesized and evaluated for their binding affinities towards 5-HT2C receptors. With regard to designed molecules 4a–i, the influence size alkyl ether absolute configuration a stereogenic center on affinity selectivity was studied. The most promising diasteromeric mixtures 4d 4e selected in initial radioligand assay they further as optically active forms starting from alcohols 5d 5e, prepared by an enzymatic kinetic resolution. Pyrimidine...
<h3>Background</h3> The cGAS-STING (<b>c</b>yclic <b>G</b>MP-<b>A</b>MP <b>s</b>ynthase-<b>st</b>imulator of <b>in</b>terferon <b>g</b>enes) signaling pathway has led to significant innate immune responses in cancer immunotherapy. 2'3'-cGAMP, the second messenger pathway, binds STING and promotes production various pro-inflammatory cytokines such as type I interferon (IFN). Therefore, activated been considered an important target for however, agonists excessively activate causing side effect...