A5101610567- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Lymphoma Diagnosis and Treatment
- Medical Imaging and Analysis
- Musculoskeletal pain and rehabilitation
- Anatomy and Medical Technology
- Viral-associated cancers and disorders
- Pelvic and Acetabular Injuries
- Chronic Lymphocytic Leukemia Research
- Scoliosis diagnosis and treatment
- Multiple Myeloma Research and Treatments
- Knee injuries and reconstruction techniques
- CNS Lymphoma Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Lower Extremity Biomechanics and Pathologies
- Bacterial Identification and Susceptibility Testing
- Otitis Media and Relapsing Polychondritis
- Surgical Simulation and Training
- Hematological disorders and diagnostics
- Neutropenia and Cancer Infections
- Antifungal resistance and susceptibility
- Vascular Malformations and Hemangiomas
- Advanced Radiotherapy Techniques
- Bone Tissue Engineering Materials
- Soft Robotics and Applications
Jining First People's Hospital
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2023
Institute of Hematology & Blood Diseases Hospital
2019-2023
Southern Medical University
2013-2022
Third Affiliated Hospital of Southern Medical University
2021
Comparing with X-ray, ultrasound imaging has the advantages of no radiation and easy operation, etc., which is expected to be an effective alternative in clinical assessment for human spine. At present, freehand scanning mainly used field, recently robot-assisted emerged as a promising way gradually reduce intervention. However, automatic recognition scanning, well control strategy robots that guarantee tight coupling between probe skin, are still challenges. Moreover, current measurement...
Background With the properties of three-column fixation and anterior-approach-only procedure, anterior transpedicular screw (ATPS) is ideal for severe multilevel traumatic cervical instabilities. However, accurate insertion ATPS remains challenging. Here we constructed a patient-specific biocompatible drill template evaluated its accuracy in assisting insertion. Methods After ethical approval, 24 formalin-preserved vertebrae (C2–C7) were CT scanned. 3D reconstruction models vertebra obtained...
Background: Intervertebral disc degeneration (IDD) underlies the pathogenesis of degenerative diseases spine; however, its exact molecular mechanism is unclear. Purpose: To explore mechanical pressure (MP)-induced IDD and to assess role Rosuvastatin (RSV) inhibits MP-induced IDD. Methods: SD rat nucleus pulposus cells (NPCs) were cultured in vitro an apoptosis model NPCs was constructed using MP. Proliferative activity, reactive oxygen species content, apoptosis, wound healing detected each...
Background: Ligament repair and augmentation techniques can stabilize syndesmosis injuries. However, little is known about the mechanical behavior of syndesmotic ligaments. The aim this study was to analyze full-field strain, strain trend under foot rotation, subregional differences anterior inferior tibiofibular ligament (AITFL), posterior (PITFL), interosseous membrane (IOM). Methods: Eleven fresh-frozen lower limbs were dissected expose AITFL, PITFL, IOM. underwent rotation from 0° 25°...
Purpose: To investigate the molecular mechanism underlying inhibitory effect of sinomenine (SN) on interleukin-1β (IL-1β)-induced apoptosis in nucleus pulposus cells (NPCs), and to evaluate potential role SN preventing intervertebral disk degeneration (IDD). Methods: The Rat NPCs were cultured vitro identified using Hematoxylin-Eosin (HE) staining, toluidine blue immunofluorescence analysis. pretreated with or without SN, then induced IL-1β assess cell viability, ROS levels, apoptotic rates,...
Aims The aim of this study was to compare the peak pull-out force (PPF) pedicle-lengthening screws (PLS) and traditional pedicle (TPS) using instant cyclic fatigue testing. Materials Methods A total 60 lumbar vertebrae were divided into six groups: PLS submitted fatigue-resistance testing (groups A1 A2, respectively), TPS B1 B2, respectively) augmented with 2 ml polymethylmethacrylate, C1 C2, respectively). PPF normalized (PPFn) for bone mineral density (BMD) compared within between all...
Objective: To investigate the clinical status of lymphoid tissue neoplasms patients with bacteria bloodstream infections, bacteriology and drug susceptibility results, provide basis for rational anti-infection option. Methods: A retrospectively analysis data bacterial test results infections from September 2010 to December 2014 was conducted. Results: total 134 cases including 107 were enrolled. 84 male, 50 female, median age 31 (12-71) years old. 112 agranulocytosis, 106 severe...
Objective: To investigate the curative effect of hairy cell leukemia by clatabine. Methods: The clinical data 24 patients with treated cladribine from November 2006 to October 2017 were analyzed retrospectively, then and adverse drug reaction analyzed. Results: ① A total including 22 male 2 female, median age was 49.5 years (range 33 76) at diagnosis. There 20 splenomegaly (4 mild splenomegaly, 4 moderate 12 massive splenomegaly), 3 enlargement lymph nodes, 1 who had undergone splenectomy....
Background: Cryptococcus neoformans infection has significantly increased recently, particularly in AIDS patients and immunocompromised individuals. At present, it is unclear how C. traversesthe alveolar-capillary interface causes infection. Previous study show that capsular hyaluronic acid (HA) was a virulent factor CD44 the major HA receptor on HBMEC during Methods & Materials: Our examined characterized interaction of with human pulmonary microvascular endothelial cells (HPMEC), which...
Objective: This retrospective, single-center study aimed to evaluate the efficacy and safety of programmed death-1 (PD-1) inhibitors, either as monotherapy or in combination with chemotherapy, management relapse/refractory classical Hodgkin's lymphoma (R/R cHL) . Methods: A total 35 patients R/R cHL who received treatment at Institute Hematology Blood Diseases Hospital, Chinese Academy Medical Sciences & Peking Union College from September 2016 December 2020 were enrolled this study. Among...
Objective: To evaluate the efficacy and long-term outcome of a combined protocol for multiple myeloma (MM) , including induction therapy, autologous hematopoietic stem cell transplantation (ASCT) consolidation maintenance therapy. Methods: Clinical records 144 patients with MM from January 1, 2005 to February 2016 were retrospectively analyzed. Results: The overall response rate (ORR) after ASCT was 100.0%, in which complete remission (CR) 64.1% best treatment superior PR 89.4%. During...
Background: Cytogenetic aberration detected by fluorescence in situ hybridization is one of the most important prognostic factors for multiple myeloma (MM). Identifying patients with high risk aberrations (HRA) critical initial stratification as well follow‐up treatment. Although specific HRA has been discussed, cumulative impact still unclear. Also, limited published reports on this issue were almost conducted context traditional chemotherapy, incomplete FISH detections. Aims: Based our...
Objective: To investigate the efficacy of fludarabine and cyclophosphamide combined with rituximab (FCR) in previously untreated patients chronic lymphocytic leukemia (CLL) . Methods: The clinical data 43 enrolled from May 2004 to December 2017 were analyzed survival results. Results: A total 31 males 12 females, median age was 58 years old (range 36 to72) before treatment. There 8 symptom B. number peripheral blood lymphocyte 26 (3-550) ×10(9)/L. IGHV unmutated detected 62.1% (18/29)...