A5024907062- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- Bone Metabolism and Diseases
- Knee injuries and reconstruction techniques
- S100 Proteins and Annexins
- Bone health and treatments
- Infectious Diseases and Tuberculosis
- Magnesium Alloys: Properties and Applications
- Titanium Alloys Microstructure and Properties
- TGF-β signaling in diseases
- Osteoarthritis Treatment and Mechanisms
- Osteomyelitis and Bone Disorders Research
- Orthopedic Infections and Treatments
- Lower Extremity Biomechanics and Pathologies
- Total Knee Arthroplasty Outcomes
- Periodontal Regeneration and Treatments
- Sports injuries and prevention
- Foot and Ankle Surgery
Nanfang Hospital
2011-2024
Southern Medical University
2011-2024
The competition between cells integration and bacterial colonization determines the fate of implantations. To reveal effects clinical implant topographies on osteoblast differentiation biofilm formation, a series micron/submicron/nano-hierarchical structures were created at pure titanium surfaces (Ti-I, Ti-II, Ti-III). It was found that hierarchical promoted MC3T3-E1 cell through contact guidance Ti-II processed best osteogenic ability. Undesirably, further accelerated formation due to...
To investigate the molecular pathogenesis of bone with osteomyelitis, we developed implant-associated osteomyelitis (IAOM) models in mice. An orthopedic stainless pin was surgically placed right femoral midshaft mice, followed by an inoculation Staphylococcus aureus into medullary cavity.
We developed an innovative method to include quercetin into alpha-calcium sulphate hemihydrate/nano-hydroxyapatite (α-CSH/n-HA), prepare a novel quercetin-containing α-CSH/n-HA composite (Q-α-CSH/n-HA). The physicochemical properties, and ability of Q-α-CSH/n-HA promote cell proliferation, migration, osteogenic differentiation bone marrow stem cells (BMSCs) in vitro were examined. Further, the potential defect repair was studied using Sprague-Dawley rat model critical tibial defects. Imaging...
In the mammalian skeletal system, osteogenesis and angiogenesis are closely linked by type H vessels during bone regeneration repair. Our previous studies confirmed promotion of these processes copper-containing metal (CCM) in vitro vivo . However, whether how coupling participates CCM is unknown. this study, M2a macrophages but not M2c were shown to be immunoregulated CCM. A CCM, 316L−5Cu, was applied drilling hole injuries tibia C57/6 mice for comparison. We observed advanced formation...
To achieve osteogenesis, angiogenesis, and neurogenesis for repairing bone defects, we constructed an anisotropic microspheres–cryogel composite loaded with magnesium l-threonate (MgT). These composites were prepared by the photo-click reaction of norbornene-modified gelatin (GB) in presence MgT-loaded microspheres through bidirectional freezing method. The possessed macroporous (around 100 μm) structure sustained release bioactive Mg2+, which facilitate vascular ingrowth. could...
Background: Ligament repair and augmentation techniques can stabilize syndesmosis injuries. However, little is known about the mechanical behavior of syndesmotic ligaments. The aim this study was to analyze full-field strain, strain trend under foot rotation, subregional differences anterior inferior tibiofibular ligament (AITFL), posterior (PITFL), interosseous membrane (IOM). Methods: Eleven fresh-frozen lower limbs were dissected expose AITFL, PITFL, IOM. underwent rotation from 0° 25°...
Objective To explore the effects of cyclic tensile stresses different magnitudes on expressions apoptosis cytokines and transforming growth factors (TGF) in chondrocytes. Methods Classical methods were used to culture primary chondrocytes New Zealand rabbits. Mechanical exerted onto mono-layer cells cultured by FLEXERCELL-5000T system. The experiment was conducted 3 groups: low magnitude stress group (5% ), high (15% ) control group. applied for 5 days 8 hours per day. harvested S measure...