A5033444295- RNA regulation and disease
- Epilepsy research and treatment
- MicroRNA in disease regulation
- Neuroscience and Neuropharmacology Research
- RNA Research and Splicing
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- Functional Brain Connectivity Studies
- Genetic Neurodegenerative Diseases
- Cancer Diagnosis and Treatment
- CCD and CMOS Imaging Sensors
- Genetics and Neurodevelopmental Disorders
- Pharmacological Effects and Toxicity Studies
- Pancreatitis Pathology and Treatment
- Neural dynamics and brain function
- Cancer Immunotherapy and Biomarkers
- Metabolism and Genetic Disorders
- Cell Adhesion Molecules Research
- CAR-T cell therapy research
- Abdominal Trauma and Injuries
- Gallbladder and Bile Duct Disorders
- Mitochondrial Function and Pathology
- Colorectal Cancer Treatments and Studies
- Immune Response and Inflammation
- Endoplasmic Reticulum Stress and Disease
Universidade Estadual de Campinas (UNICAMP)
2019-2024
Brazilian Institute of Neuroscience and Neurotechnology
2020-2021
Christchurch Hospital
1991
SUNY Cortland
1982
Abstract Focal cortical dysplasia is a highly epileptogenic malformation with few treatment options. Here, we generated human organoids from patients focal type II. Using this model, mimicked some hallmarks, such as impaired cell proliferation, the presence of dysmorphic neurons and balloon cells, neuronal network hyperexcitability. Furthermore, observed alterations in adherens junctions zonula occludens-1 partitioning defective 3, reduced polarization actin cytoskeleton, fewer synaptic...
C-terminal binding protein 2 (CTBP2) gene can be related with mechanisms involved in the pathogenesis of type II Focal cortical dysplasia (FCD).The main goal this work is to investigate frequency a single nucelotide variant (SNV) identified CTBP2, rs76555439, cohort patients FCD and compare it healthy control individuals.
Mesial temporal lobe epilepsy (MTLE) stands out among the different types of due to its prevalence and high rate resistance treatment with antiepileptic drugs (AEDs). Because challenge predict which patients will respond drug treatments, alternative therapies seizures, such as surgery, may take many years be indicated. Thereby, search for new biomarkers, capable predicting pateitns witll AED is necessary. The metabolomic approach has advantages over other molecular techniques, greater...