A5016193706- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lymphoma Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Muscle Physiology and Disorders
- Radiology practices and education
- Radiomics and Machine Learning in Medical Imaging
- Eicosanoids and Hypertension Pharmacology
- Radiation Dose and Imaging
- Peroxisome Proliferator-Activated Receptors
- Viral-associated cancers and disorders
- Immune Response and Inflammation
- Ultrasound in Clinical Applications
- CNS Lymphoma Diagnosis and Treatment
- Genetic Neurodegenerative Diseases
- Fatty Acid Research and Health
- Cardiac Ischemia and Reperfusion
- HIV-related health complications and treatments
- Diet, Metabolism, and Disease
- Polyomavirus and related diseases
- Organ and Tissue Transplantation Research
- Tracheal and airway disorders
- Neurogenetic and Muscular Disorders Research
Durham VA Medical Center
2024-2025
Geriatric Research Education and Clinical Center
2025
Duke University Hospital
2024
Duke Medical Center
2023-2024
Duke University
2023
Clinical Research Institute
2023
The University of Texas Southwestern Medical Center
2019-2020
Southwestern Medical Center
2019
Emory University
2005-2017
University of Georgia
2014
The vacuolar proton pyrophosphatase (H(+) -PPase) of Toxoplasma gondii (TgVP1), a membrane pump, localizes to acidocalcisomes and novel lysosome-like compartment termed plant-like vacuole (PLV) or (VAC). We report the characterization T. null mutant for TgVP1 gene. Propagation these mutants decreased significantly because deficient attachment invasion host cells, which correlated with microneme secretion. Processing cathepsin L (CPL) in was only when parasites were incubated presence low...
Carli J. Lehr, MD, PhD; Lyla Mourany, MS; Paul Gunsalus, Johnie Rose, Maryam Valapour, MPP; Jarrod E. Dalton, PhD
Separately, chronic alcohol ingestion and HIV-1 infection are associated with severe skeletal muscle derangements, including atrophy wasting, weakness, fatigue. One prospective cohort study reported that 41% of HIV-infected patients met the criteria for alcoholism, however; few reports exist on co-morbid effects these two disease processes homeostasis. Thus, we analyzed atrophic in transgenic rats identified alterations to several catabolic anabolic factors.Relative plantaris mass, total...
Aims: To assess the effectiveness of procysteine (PRO) supplementation provided during a period abstinence (ABS) on alcohol-induced skeletal muscle atrophy and oxidant stress. Methods: Age- gender-matched Sprague–Dawley rats were fed Lieber–DeCarli liquid diet containing either alcohol or an isocaloric substitution (control diet) for 12 week. Next, subgroups alcohol-fed control 2 week supplemented with PRO (0.35%, w/v) vehicle. Plantaris morphology was assessed by hematoxylin eosin staining....
Mantle cell lymphoma (MCL) is a heterogeneous disease with high relapse rates. Limited data guide the use of surveillance imaging following treatment. We constructed retrospective cohort from two academic institutions patients MCL who completed first-line therapy and underwent follow-up for relapse, analyzing effect on survival. Of 217 patients, 102 had documented 38 (37%) diagnosed by 64 (63%) other methods. Relapse diagnosis no significant advantage in overall survival date (hazard ratio...
Innovations in organ preservation, surgical technique, and post-operative care have transformed solid transplantation. As transplantation becomes more common, potential racial, ethnic, socioeconomic inequities the referral selection process are also emerging. Research studies highlight that patients from minoritized low groups experience lower rates of referrals, reduced access to transplant waitlist, higher postoperative complications, mortality for cardiothoracic (lung/heart) abdominal...
Acute exacerbations of interstitial lung disease (AE-ILD) cause severe respiratory failure, and mortality is high despite treatment. Lung transplantation an effective therapy for late-stage (ILD), but prior studies on post-transplant outcomes patients trandsplanted in AE-ILD are conflicting. We performed a retrospective evaluation all first-time transplant recipients ILD at our institution between May 1, 2005, April 2019. Patients were stratified according to published consensus definition...
Background: The US rate of Donation after Circulatory Death (DCD) Heart Transplant (HT) increased threefold from 2020 to 2022. While early analyses DCD HT have suggested similar outcomes compared donation brain death HT, this may be the result a restrictive donor and recipient selection process, intended minimize risk in first cohorts. Hypothesis: We hypothesized that profiles for donors recipients over time, as has rapidly expanded. sought identify longitudinal changes 2019-2023, determine...
HomeCirculation: Heart FailureVol. 16, No. 12Longitudinal Trends in Donor and Recipient Risk Profile, Clinical Outcomes, for Donation After Circulatory Death Transplantation Free AccessResearch ArticlePDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree ArticlePDF/EPUBLongitudinal Joseph B. Lerman, Daniel M. Guidot, Cynthia L. Green, Chetan Patel, Richa Agarwal, Nancy K....
Chronic alcohol exposure in rats induces oxidative stress the lung via angiotensin II pathway and elicits an increase expression of profibrotic mediator, transforming growth factor β1 (TGF-β1). In addition, fibronectin is increased lungs alcohol-fed rats. These data strongly suggest that mechanisms are activated response to chronic exposure, if true, this would abuse might risk fibrotic diseases. Consistent with hypothesis, we have recently determined ingestion increases TGF-β1 collagen...
<h3></h3> Alcohol abuse increases the risk of developing acute respiratory distress syndrome (ARDS) ˜ 3-fold in septic patients. We have shown that chronic ethanol ingestion rats impairs alveolar epithelial barrier function and sepsis-mediated lung injury vivo. Recently we determined ethanol-induced dysfunction is corrected by treatment with granulocyte-macrophage colony-stimulating factor (GM-CSF). Interestingly, a Phase II clinical trial from Australia published 2002 suggested GM-CSF...
<h3></h3> Primary graft failure following lung transplantation bears considerable resemblance to the acute respiratory distress syndrome. There is leakage of inflammatory cells and proteinaceous fluid into alveolar airspace, leading hypoxemia, failure, death in as many 50% cases. Despite improvements allograft identification, procurement, preservation, incidence primary 15 20%. Central pathogenesis epithelial cell dysfunction, a phenomenon also seen alcoholics. Previously, we have shown that...
<h3></h3> Chronic alcohol abuse impairs alveolar macrophage immune function and renders patients susceptible to severe pneumonia acute lung injury. Macrophage maturation require priming by granulocyte-macrophage colony-stimulating factor (GM-CSF), which is produced the epithelium signals via specific cell surface receptors. The GM-CSF receptor composed of a binding subunit (GM-CSFRα) signaling (GM-CSFRβ), must be coordinately expressed inserted into membrane in order for respond stimulation....