A5066952258- Pancreatic function and diabetes
- Clostridium difficile and Clostridium perfringens research
- Helicobacter pylori-related gastroenterology studies
- SARS-CoV-2 and COVID-19 Research
- Diet and metabolism studies
- Microscopic Colitis
- Digestive system and related health
- Erythrocyte Function and Pathophysiology
- Gut microbiota and health
- CRISPR and Genetic Engineering
- Metabolism, Diabetes, and Cancer
- Drug Transport and Resistance Mechanisms
- Endoplasmic Reticulum Stress and Disease
- RNA and protein synthesis mechanisms
- Cancer Cells and Metastasis
- Viral gastroenteritis research and epidemiology
- Adipose Tissue and Metabolism
- RNA Research and Splicing
- Polyamine Metabolism and Applications
- Gastrointestinal motility and disorders
- Birth, Development, and Health
- Gastroesophageal reflux and treatments
- Lipid Membrane Structure and Behavior
- Mycobacterium research and diagnosis
- Animal Genetics and Reproduction
University of British Columbia
1997-2023
British Columbia Children's Hospital
2019-2023
Stanford University
2022
Youngstown State University
2016
Schüchtermann-Klinik
2008-2014
University of Bath
1981-1999
Salford Royal Hospital
1980-1997
University of Manchester
1980-1997
Reade (Brazil)
1997
University of Salford
1980-1997
The COVID-19 pandemic caused by the SARS-CoV-2 virus remains a global public health crisis. Although widespread vaccination campaigns are underway, their efficacy is reduced owing to emerging variants of concern
Beyond the short-term effects on fertility, there is increasing evidence that obesity or consumption of an inappropriate diet by mother during pregnancy adversely affects long-term health her offspring. PPAR and RXR isotypes are widely expressed in reproductive tissues developing fetus. Through their interactions with fatty acids, they may mediate adaptive responses to changes maternal diet. In maturing follicle, PPAR-gamma has important role granulosa cells surround oocyte. After...
Abstract Background and Aims Endoplasmic reticulum [ER] stress in intestinal epithelial cells [IECs] contributes to the pathogenesis of inflammatory bowel disease [IBD]. We hypothesized that ER changes innate signalling human IECs, augmenting toll-like receptor [TLR] responses inducing pro-inflammatory underlying dendritic [DCs]. Methods Caco-2 primary colon-derived enteroid monolayers were exposed ATP [control stressor] or thapsigargin [Tg] [ER inducer], stimulated with TLR5 agonist...
The gas and gadd family of genes, known collectively as the growth arrest are associated with negative control mammalian cell growth. steady-state levels their mRNAs increased by three to fivefold when exponentially multiplying cells exposed a variety stresses including inadequate nutrition or removal serum. Reverse transcription-polymerase chain reaction (RT-PCR) has been used analyze gene expression in preimplantation mouse embryo. gas5, gas6, CHOP-10 (gadd153, Ddit3) genes were expressed...
Our previous studies revealed that lactoferrin (LF) reconstitutes the cellular and humoral immune response in cyclophosphamide-treated mice. The aim of this investigation was to establish whether suppressory effects methotrexate (MTX) on can be modulated by LF. We found MTX, given intraperitoneally (i.p.) at a dose 200 mg/kg b.w., 48 h following sensitization CBA mice with ovalbumin (OVA), reduced 80% delayed type hypersensitivity (DTH) response. Co-administration LF drinking water (0.5%...
Acute damage to the intestinal epithelium can be repaired via de-differentiation of mature epithelial cells (IECs) a stem-like state, but there is lack knowledge on how stem function after chronic injury, such as in inflammatory bowel disease (IBD). We developed chronic-injury model human colonoid monolayers by repeated rounds air-liquid interface and submerged culture. use this understand affects ability IECs (1) respond microbial stimulation, using Toll-like receptor 5 (TLR5) agonist FliC...
Summary The COVID-19 pandemic caused by the SARS-CoV-2 virus remains a global public health crisis. Although widespread vaccination campaigns are underway, their efficacy is reduced against emerging variants of concern (VOCs) 1,2 . Development host-directed therapeutics and prophylactics could limit such resistance offer urgently needed protection VOCs 3,4 Attractive pharmacological targets to impede viral entry include type-II transmembrane serine proteases (TTSPs), as TMPRSS2, whose...