A5070166763- Animal Virus Infections Studies
- Virus-based gene therapy research
- Parvovirus B19 Infection Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Influenza Virus Research Studies
- Animal Disease Management and Epidemiology
- Tumors and Oncological Cases
- Immune Cell Function and Interaction
- Viral Infections and Immunology Research
- interferon and immune responses
- Respiratory viral infections research
- Herpesvirus Infections and Treatments
- Viral gastroenteritis research and epidemiology
- T-cell and B-cell Immunology
- Liver Disease Diagnosis and Treatment
- Primate Behavior and Ecology
- Infectious Diseases and Mycology
- Cannabis and Cannabinoid Research
- Hepatitis B Virus Studies
- Bird parasitology and diseases
- Sarcoma Diagnosis and Treatment
- Thermal Regulation in Medicine
- COVID-19 Impact on Reproduction
New York State College of Veterinary Medicine
2017-2025
Cornell University
2017-2025
British Veterinary Association
2020
American College of Veterinary Internal Medicine
2020
MRC Epidemiology Unit
2020
London School of Hygiene & Tropical Medicine
2020
The COVID-19 pandemic caused by the SARS-CoV-2 virus remains a global public health crisis. Although widespread vaccination campaigns are underway, their efficacy is reduced owing to emerging variants of concern
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing the ongoing global pandemic associated with morbidity and mortality in humans. Although disease severity correlates immune dysregulation, cellular mechanisms of inflammation pathogenesis COVID-19 remain relatively poorly understood. Here, we used mouse-adapted SARS-CoV-2 strain MA10 to investigate role adaptive cells disease. We found that while infected wild-type mice lost ~10% weight by 3 4 days postinfection,
Equine parvovirus-hepatitis (EqPV-H) has recently been associated with cases of Theiler's disease, a form fulminant hepatic necrosis in horses. To assess whether EqPV-H is the cause we first demonstrated hepatotropism by PCR on tissues from acutely infected We then experimentally inoculated horses and 8 10 developed hepatitis. One horse showed clinical signs liver failure. The onset hepatitis was temporally seroconversion decline viremia. Liver histology situ hybridization lymphocytic...
Pathology studies of SARS-CoV-2 Omicron variants concern (VOC) are challenged by the lack pathogenic animal models. While BA.1 and BA.2 replicate in K18-hACE2 transgenic mice, they cause minimal to negligible morbidity mortality, less is known about more recent VOC. Here, we show that contrast BA.1, BA.5-infected mice exhibited high levels correlating with higher early viral loads. Neither nor BA.5 replicated brains, unlike most prior Only BA.5–infected substantial weight loss, pathology...
Abstract OBJECTIVE To compare the pharmacokinetics of cannabidiol (CBD) and cannabidiolic acid (CBDA) in horses to evaluate safety their chronic administration. METHODS CBD- CBDA-rich oil (1 mg/kg) were administered orally twice daily 7 adult over 6 weeks a randomized, crossover design with 2-week washout period. A 12-hour pharmacokinetic analysis was conducted on day 1 each 6-week trial, followed by measurement peak trough concentrations at 1, 2, 4, 6. The cannabinoids assessed via physical...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza viruses lead to severe illnesses death in humans, exacerbated individuals with underlying health conditions, remaining substantial global public concerns. Here, we developed a bivalent replication-incompetent single-cycle pseudotyped vesicular stomatitis virus vaccine that incorporates both prefusion-stabilized SARS-CoV-2 spike protein lacking furin cleavage site full-length A neuraminidase protein. Vaccination of...
Induced pluripotent stem cells (iPSCs) can propagate indefinitely and give rise to every other cell type, rendering them invaluable for disease modelling, drug development research, usage in regenerative medicine. While feline iPSCs have been described, there are currently no reports on generating genome integration (footprint)-free from domestic cats. Therefore, the objective of this study was generate fetal fibroblasts using non-integrative Sendai virus (SeV) vectors carrying human...
ABSTRACT COVID-19 can cause neurological symptoms such as fever, dizziness, and nausea. However, of SARS-CoV-2 infection have been hardly assessed in mouse models. In this study, we infected two commonly used wild-type lines (C57BL/6J 129/SvEv) a 129S calcitonin gene-related peptide (αCGRP) null-line with mouse-adapted demonstrated signs including We then evaluated whether CGRP receptor antagonist, olcegepant, “gepant” antagonist migraine treatment, could mitigate acute neuroinflammatory...
Equine parvovirus-hepatitis (EqPV-H) has been proposed as the aetiological cause of Theiler's disease, also known serum hepatitis. EqPV-H-associated disease not previously reported in Europe.To determine whether EqPV-H infection was associated with a 2018-2019 outbreak four horses on studfarm.Descriptive case series.The medical records from same farm diagnosed fatal were examined retrospectively. Information collected included clinical history, physical examination findings, tetanus...
Summary The COVID-19 pandemic caused by the SARS-CoV-2 virus remains a global public health crisis. Although widespread vaccination campaigns are underway, their efficacy is reduced against emerging variants of concern (VOCs) 1,2 . Development host-directed therapeutics and prophylactics could limit such resistance offer urgently needed protection VOCs 3,4 Attractive pharmacological targets to impede viral entry include type-II transmembrane serine proteases (TTSPs), as TMPRSS2, whose...
Chronic viral infections, such as HIV and hepatitis C virus, represent a major public health problem. Although it is well understood that neonates adults respond differently to chronic the underlying mechanisms remain unknown. In this study, we transferred neonatal adult CD8+ T cells into mouse model of infection (lymphocytic choriomeningitis virus clone 13) dissected out key cell-intrinsic differences alter their ability protect host. Interestingly, found preferentially became effector...
Cedar virus (CedV) is a nonpathogenic member of the Henipavirus (HNV) genus emerging viruses, which includes deadly Nipah (NiV) and Hendra (HeV) viruses. CedV forms syncytia, hallmark henipaviral paramyxoviral infections pathogenicity. However, intrinsic fusogenic capacity relative to NiV or HeV remains unquantified. HNV entry mediated by concerted interactions between attachment (G) fusion (F) glycoproteins. Upon receptor binding G head domain, fusion-activating stalk region exposed...
Canid alphaherpesvirus 1 (CHV) causes morbidity and mortality in susceptible puppies. While the neuropathology of experimentally infected puppies has been detailed, characterization naturally acquired infections is limited. The aim this study was to describe histologic, immunohistochemical, situ hybridization features CHV encephalitis dog. Six female 11 male ranging age from stillborn 57 days old were included. Histologically, lesions included multifocal glial nodules (16/17, 94%), meningeal...
A seven-year-old male castrated mixed-breed dog was diagnosed with bilateral subconjunctival masses. In vivo confocal microscopy facilitated visualization of Onchocerca lupi adult nematodes and their characteristic cuticular morphology. Long, thin, white were extracted during excisional biopsy. Histopathologic parasitologic evaluation confirmed the diagnosis O. lupi. addition to surgical debulking parasitic granulomas, received systemic doxycycline, prednisone, ivermectin therapy. repeated...
Abstract Enveloped viruses can cause devastating zoonotic diseases and are the most likely to global pandemics. We identified a new class of small-molecule sulfur-containing antiviral compounds (XM series) that broadly inhibit enveloped viruses. The antivirals’ mechanism action was explored via various multidisciplinary approaches, concluding XM antivirals alter membrane lipid chemical compositions, increase order deep within hydrophobic region bilayer, phase transition temperatures. Such...
A 26-y-old, male, captive Humboldt penguin ( Spheniscus humboldti) was euthanized following a 3.5-mo history of weakened elimination mechanics, recurrent tenesmus, intermittent hemorrhagic droppings, and cloacal mass. Blepharospasm, unknown cause, the right eye present for ~3 mo before euthanasia. Autopsy revealed adenocarcinoma with localized coelomic carcinomatosis distant metastases to liver lungs. On histopathology, 2.6 × 1.2 0.5-mm, well-demarcated mass found surrounding optic nerve,...
Abstract Background Theiler’s disease, a.k.a. equine serum hepatitis, is a devastating, highly fatal disease of horses. Equine parvovirus-hepatitis (EqPV-H) has been identified as the likely cause this disease. While incidence low, prevalence EqPV-H DNA in horses high, with up to 37% some regions, suggesting that subclinical or persistent infection common. Methods To determine and pathogenicity at New York racetracks, was extracted from archived formalin-fixed, paraffin-embedded liver...
Skunk adenovirus-1 (SkAdV-1) has been reported infecting several North American wildlife species; however, lesions associated with disease have not yet completely characterized, particularly in porcupines. We describe and characterize the tissue distribution SkAdV-1 infection 24 diagnostic cases submitted between 2015 2020, including 16 porcupines (Erethizon dorsatum), three striped skunks (Mephitis mephitis), five raccoons (Procyon lotor), which constitute a new host species. The most...
Abstract COVID-19 can result in neurological symptoms such as fever, headache, dizziness, and nausea. However, signs of SARS-CoV-2 infection have been hardly assessed mouse models. Here, we infected two commonly used wildtype mice lines (C57BL/6 129S) with mouse-adapted demonstrated including motion- related dizziness. We then evaluated whether the Calcitonin Gene-Related Peptide (CGRP) receptor antagonist, olcegepant, migraine treatment could mitigate acute neuroinflammatory responses to...