A5016415916- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Microwave-Assisted Synthesis and Applications
- Radical Photochemical Reactions
- Multicomponent Synthesis of Heterocycles
- Chemical Synthesis and Analysis
- Synthesis and Biological Evaluation
- Fluorine in Organic Chemistry
- Advanced NMR Techniques and Applications
- Crystallography and molecular interactions
- Microfluidic and Capillary Electrophoresis Applications
- Sulfur-Based Synthesis Techniques
- Electron Spin Resonance Studies
- Phytochemicals and Antioxidant Activities
- Historical Studies in Latin America
- Analytical Chemistry and Chromatography
- Synthetic Organic Chemistry Methods
- Oxidative Organic Chemistry Reactions
- Dendrimers and Hyperbranched Polymers
- Synthesis and Reactions of Organic Compounds
- Graphene and Nanomaterials Applications
- Forest Management and Policy
- History and Politics in Latin America
- Fermentation and Sensory Analysis
- Historical and socio-economic studies of Spain and related regions
University of Tarapacá
2025
University of Castilla-La Mancha
2015-2024
Pontificia Universidad Católica de Chile
2024
Chapingo Autonomous University
2021
Hospital General Universitario de Ciudad Real
2015-2020
Instituto de Investigación en Recursos Cinegéticos
2017
Universidad Nacional Autónoma de México
2010-2015
Instituto de Síntesis Química y Catálisis Homogénea
2015
Universidad de Zaragoza
2015
Cincinnati Children's Hospital Medical Center
2013-2015
Old industrial cities have made broad use of new strategies as the means to overcome difficulties created by restructuring their former economic basis. Although usually based on physical practices, these attempted ease transformation towards a services‐based economy, which has been presented essential solve cities’ problems. Even if it widespread currency, effectiveness this formula is not clear, its impact city Glasgow illustrates. Yet, at present, Bilbao, Basque variant one those old...
To gain knowledge of the characteristic flavonol 3-O-glycosides red grape Vitis vinifera varieties, we isolated fraction from V. cv. Petit Verdot skins by solid-phase extraction using a combination reverse-phase and ion-exchanging materials. This procedure allowed us to separate anthocyanin-free that was further split into neutral acidic subfractions, thus facilitating identification. By means semipreparative high-performance liquid chromatography, several these for structural elucidation....
Among the methods to enhance sensitivity of nuclear magnetic resonance (NMR) spectroscopy, small-diameter NMR coils (microcoils) are promising tools tackle study mass-limited samples. Alternatively, hyperpolarization schemes based on dynamic polarization techniques provide strong signal enhancements target Here we present a method effortlessly perform photo-chemically induced in microcoil setups boost detection down sub-picomole limits 9.4T system (400 MHz 1H Larmor frequency). This setup is...
High-resolution solution NMR spectroscopy has been used to characterize the structure of Pd dendrimer-encapsulated nanoparticles (DENs), consisting approximately 55-atom encapsulated within fourth-generation, hydroxyl-terminated poly(amidoamine) PAMAM dendrimers (G4-OH). Detailed analysis 1D and 2D spectra with (G4-OH(Pd(55))) without (G4-OH) unambiguously demonstrate that single are individual dendrimers. This conclusion is based on following results. First, data show signals arising from...
The merging of photoredox and transition-metal catalysis has become one the most attractive approaches for carbon-carbon bond formation. Such reactions require use two organo-transition-metal species, which acts as a photosensitizer other cross-coupling catalyst. We report herein an exogenous-photosensitizer-free photocatalytic process formation bonds by direct acceleration well-known nickel-catalyzed Negishi that is based on naturally abundant metals. This finding will open new avenues in...
The article is based on methodological reflections and recollections from two qualitative cross-national research projects, one of them comparing Finland Scotland, the other Scotland Spain. One was a case-oriented study local regeneration strategies in cities, while used an ethnographic approach for practices maternity child healthcare services. authors’ dialogue it contributes to discussion about value comparisons its place field comparative research. It points at advantages enabling...
Objective— Calcific aortic valve disease (CAVD) is a significant cause of morbidity and mortality, which affects ≈1% the US population characterized by calcific nodule formation stenosis valve. Klotho -deficient mice were used to study molecular mechanisms CAVD as they develop robust (AoV) calcification. Through microarray analysis AoV tissues from klotho wild-type mice, increased expression gene encoding cyclooxygenase 2 (COX2; Ptgs2 ) was found. COX2 activity contributes bone...
Neuropathological symptoms of Alzheimer's disease appear in advances stages, once neuronal damage arises. Nevertheless, recent studies demonstrate that early asymptomatic ß-amyloid peptide damages the cerebral microvasculature through mechanisms involve an increase reactive oxygen species and calcium, which induces necrosis apoptosis endothelial cells, leading to cerebrovascular dysfunction. The goal our work is study potential preventive effect lipophilic antioxidant coenzyme Q (CoQ)...
Low doses of GO or FLG produce a metabolic remodeling that differentially affects human skin cell death and motility.
Abstract A visible‐light‐induced Negishi cross‐coupling is enabled by the activation of a Pd 0 –Zn complex. With this photocatalytic method, scope deactivated aryl halides that can be employed in coupling was significantly expanded. NMR experiments conducted presence and absence light confirmed formation palladium–zinc complex key for accelerating oxidative addition step.
Este artículo evalúa el nivel del síndrome de burnout y su relación con variables sociodemográficas laborales en docentes educación básica colegios privados norte Chile, durante la transición entre pandemia postpandemia. Utilizando un diseño cuantitativo, descriptivo transversal, se aplicó Maslach Burnout Inventory (MBI) a una muestra 50 seleccionados aleatoriamente. Los resultados mostraron bajos general. Se constató alto agotamiento emocional, despersonalización media realización personal...
An efficient, chemoselective and environmentally friendly procedure for the oxidation of sulfides is described. Reactions are carried out using sodium perborate or percarbonate as oxidant, solvent-free conditions water reaction medium microwave irradiation conventional heating energy source. A comparative study concerning effect oxidant on yield chemoselectivity (sulfoxide vs. sulfone) has been out. In solid phase, nature support catalyst a more marked influence than electrophilic...
In this paper, we report the functionalization of surface multiwalled carbon nanotubes (MWNTs) with Au dendrimer encapsulated nanoparticles (DENs). The results show that, when pristine MWNTs having hydrophobic surfaces are exposed to DENs, dendrimers aggregate on MWNT surface. However, oxidized in acid prior exposure well-dispersed submonolayer coverages observed This suggests that acid-induced debundling is an essential prerequisite for attachment nearly monodisperse DENs. Electron...
High-resolution solution 1H NMR spectroscopy has been used to characterize the size of Pd dendrimer-encapsulated nanoparticles (DENs). The measured by this technique contain 55, 147, 200, or 250 atoms, and they are encapsulated within sixth-generation, hydroxyl-terminated poly(amidoamine) PAMAM dendrimers (G6-OH). Detailed analysis data shows that signals arising from innermost protons G6-OH(Pdn) decrease significantly as increase. A mathematical correlation between in integral value...
We report the use of a nanolitre nuclear magnetic resonance (NMR) spectroscopy microfluidic chip hyphenated to continuous-flow microlitre-microwave irradiation set-up, for on-line monitoring and rapid optimization reaction conditions.
Polyproline II (PPII) helices play vital roles in biochemical recognition events and structures like collagen form part of the conformational landscapes intrinsically disordered proteins (IDPs). Nevertheless, this structure is generally hard to detect quantify. Here, we report first thorough NMR characterization a PPII helical bundle protein, Hypogastrura harveyi "snow flea" antifreeze protein (sfAFP). J-couplings nuclear Overhauser enhancement spectroscopy confirm natively folded consisting...
Calafate (Berberis microphylla G. Forst) is an edible wild berry growing in South Patagonia that very rich anthocyanins and hydroxycinnamic acid derivatives. contains unusual phenolic compounds compared to other berries, such as anthocyanidin dihexosides, different from the common 3,5-diglucosides, isomeric esters of caffeic with hexaric acids. After isolation, their structures have been elucidated by UV-vis, MS/MS, NMR spectroscopies. The dihexosides constitute complete series...
Abstract The stereoselective synthesis of ε‐isomers dimethyl esters 1,3‐diaminotruxillic acid in three steps is reported. first step the ortho ‐palladation ( Z )‐2‐aryl‐4‐aryliden‐5(4 H )‐oxazolones 1 to give dinuclear complexes 2 with bridging carboxylates. reaction occurs through regioselective activation ‐CH bond 4‐arylidene ring carboxylic acids. second [2+2]‐photocycloaddition CC exocyclic bonds oxazolone skeleton afford corresponding ‐palladated cyclobutanes 3 . This key was...
T-Shaped 2<italic>H</italic>-benzo[<italic>d</italic>][1,2,3]triazole derivatives have been synthesized by Sonogashira coupling reactions under microwave irradiation.