The anti-obesity effects of anthocyanin and carotenoid extracts from color-fleshed potatoes were studied with 3T3-L1 cells in vitro high-fat diet (HFD)-induced obese mice vivo. Treatment adipocytes extracts, respectively, after differentiation induction significantly inhibited fat accumulation by 63.1 83.5%. Studies adipogenesis inhibition showed that the extract acts at intermediate stages, whereas influences all stages. diminished triglyceride (TG) content peroxisome proliferator-activated...

Withania somnifera (Solanaceae), commonly known as "ashwagandha", is an ayurvedic medicinal plant that has been used for promoting good health and longevity. As part of our ongoing natural product research the discovery bioactive phytochemicals with novel structures, we conducted a phytochemical analysis W. root, herbal medicine part. The investigation aided by liquid chromatography-mass spectrometry (LC/MS)-based led to isolation four withanolide glycosides (1-4), including one new...

The nuclear factor erythroid-derived 2-related 2 (NRF2) plays a pivotal role in the regulation of genes involved oxidative stress and drug detoxification. Therefore, it is important to find NRF2 inducers protect cells from excessive damage. Here, we investigated effect medicarpin isolated root Robinia pseudoacacia L. on activity HeLa cells. Medicarpin significantly induced antioxidant response elements (ARE)-luciferase concentration-dependent manner. Furthermore, not only HO-1, GCLC, NQO1...

Tomato is a widely distributed, cultivated, and commercialized vegetable crop. It contains antioxidant constituents including lycopene, tocopherols, vitamin C, γ-aminobutyric acid, phenols, flavonoids. This study determined the contents of components activities pulp with skin ten regular, six medium-sized, two small cherry tomato cultivars at red ripe (BR + 10) stage cultivated in Korea. The relationships among Hunter color coordinates, content each component, were measured by Pearson's...

Salix chaenomeloides Kimura, commonly known as pussy willow, is a deciduous shrub and tree belonging to the Salicaceae family. The genus spp. has been healing herb for treatment of fever, inflammation, pain relief. current study aimed investigate potential bioactive natural products from S. leaves evaluate their antibacterial activity against Helicobacter pylori. A phytochemical investigation ethanol (EtOH) extract led isolation 13 phenolic compounds (1–13) ethyl acetate (EtOAc) fraction,...

The fruit of Schisandra chinensis, Omija, is a well-known traditional medicine used as an anti-tussive and anti-diarrhea agent, with various biological activities derived from the dibenzocyclooctadiene-type lignans. A high-pressure liquid chromatography-diode array detector (HPLC-DAD) method was to determine seven lignans (schisandrol B, tigloylgomisin H, angeloylgomisin schisandrin A, C) in different plant parts beverages S. chinensis grown Korea. contents these descended following order:...

Rumex acetosa is a folk medicine for gastritis and gastric ulcers. In our previous study, the ethanol extract of R. inhibited ulcers protected tissue in mice induced with HCl/ethanol from Moreover, we isolated six anthraquinone compounds this plant evaluated their anti-Helicobacter pylori activity. Therefore, study was conducted to identify further related antioxidant anti-inflammatory activities bioactive constituents. Five fractions n-hexane, methylene chloride, ethyl acetate, n-butanol,...

As part of an ongoing natural product chemical research for the discovery bioactive secondary metabolites with novel structures, wild fruiting bodies Daedaleopsis confragosa were collected and subjected to biological analyses. We fractions derived from methanol extract D. bioactivity-guided fractionation because showed antibacterial activity against Helicobacter pylori strain 51, according our bioactivity screening. The n-hexane dichloromethane moderate weak H. active analyzed isolation...

, commonly known as the bonnet bellflower or deodeok, is primarily found in Eastern Asia. Its roots have been used traditionally across Asia to treat various ailments such bronchitis, coughs, asthma, and inflammation. In our ongoing efforts discover bioactive natural products, a phytochemical investigation of

Gastric problems are often caused by the well-known Helicobacter pylori (H. pylori) bacterium. One of biggest obstacles to treatment H. infections is increasing antibiotic resistance. During our search for naturally derived anti-H. compounds, six major compounds were isolated from methylene chloride (CH2Cl2) and ethyl acetate (EtOAc) fractions Rumex acetosa that showed activity. Three anthraquinones three anthraquinone glucosides identified as chemical constituents CH2Cl2 EtOAc fractions,...

Bacillus subtilis genes iolG, iolW, iolX, ntdC, yfiI, yrbE, yteT, and yulF belong to the Gfo/Idh/MocA family. The functions of ntdC are known; however, others unknown. We previously reported B. cell factory simultaneously overexpressing iolG iolW achieve bioconversion myo-inositol (MI) into scyllo-inositol (SI). YulF shares a significant similarity with IolW, NADP+-dependent SI dehydrogenase. Transcriptional abundance did not correlate that iol involved in inositol metabolism. However, when...

Reynoutria species are medicinal plants that belong to the family Polygonaceae and widely distributed in eastern Asia, North America Europe. Although phylogeny morphological anatomical studies of some Korea have been previously reported, there no discriminative chemical data available. Therefore, characterization leaf, stem root, high performance liquid chromatography–diode array detector (HPLC–DAD) analyses were carried out assess differences profiles among Korea, i.e., R. japonica,...

Bacillus subtilis is able to utilize at least three inositol stereoisomers as carbon sources, myo-, scyllo-, and D-chiro-inositol (MI, SI, DCI, respectively). NAD+-dependent SI dehydrogenase responsible for catabolism encoded by iolX. Even in the absence of functional iolX, presence or MI growth medium was found induce transcription iolX through an unknown mechanism. Immediately upstream there operon that encodes two genes, yisR iolQ (formerly known degA), each which could encode a...

As part of ongoing systematic research into the discovery bioactive secondary metabolites with novel structures from Korean wild mushrooms, we investigated a poisonous mushroom, Omphalotus japonicus (Kawam.) Kirchm. & O. K. Mill. belonging to family Marasmiaceae, which causes nausea and vomiting after consumption. The methanolic extract fruiting bodies was subjected fractionation by solvent partition, CH2Cl2 fraction analyzed for isolation compounds, aided an untargeted liquid chromatography...

Although melanogenesis is a defense mechanism against ultraviolet (UV)-induced skin damage, abnormally excessive melanin production causes pigmentation disorders. Tyrosinase, as key factor for synthesis, plays an important role in inducing pigmentation. Therefore, the inhibition of tyrosinase crucial preventing cosmetics and medicine fields. However, majority well-known inhibitors have been discontinued due to toxic effects on or lack selectivity and/or stability. In this study, we evaluated...

Pinus eldarica is a medicinal tree used in traditional herbal medicine for the treatment of bronchial asthma and various skin diseases. As part our ongoing search bioactive phytochemicals with novel structures natural products, we performed phytochemical analysis methanol (MeOH) extract from P. needles collected Iran. Phytochemical investigation MeOH extract, aided by liquid chromatography–mass spectrometry-based analysis, resulted isolation identification three labdane-type diterpenes...

The fruit of Tetradium ruticarpum, known as Evodiae Fructus, is a traditional herbal medicine used to treat gastric and duodenal ulcers, vomiting, diarrhea. usage can be potentially associated with the antibacterial activity T. ruticarpum fruits against Helicobacter pylori. However, so far, components H. pylori has not been investigated despite folk use. current study was conducted investigate bioactive chemical evaluate their Phytochemical investigation EtOH extract led isolation...

Mangifera indica L., a member of the Anacardiaceae family, is widely cultivated across globe. The leaves M. are renowned for their medicinal properties, attributed to abundance bioactive compounds. This study investigated effects mango leaf extract on oxidative stress in HeLa cells. Notably, n-hexane fraction (MLHx) significantly enhanced antioxidant response element (ARE)-luciferase activity at concentration 100 µg/mL, surpassing other fractions. MLHx also promoted expression HO-1 mRNA by...

Salix koreensis Anderss (Salicaceae), commonly referred to as Korean willow, is native East Asia, particularly Korea and China, it has been used in traditional folk medicine for its potent anti-inflammatory, analgesic, antioxidant properties. In our ongoing research efforts discover biologically new natural products, phytochemical analysis on an ethanolic extract of S. twigs yielded the isolation identification ten phenolic compounds (1–10), including a newly discovered glycoside (1) named...

Ulmus species (Ulmaceae) are large deciduous trees distributed throughout Korea. Although their root and stem bark have been used to treat gastrointestinal diseases wounds in folk medicine, commercial products consumed without any standardization. Therefore, we examined anatomical chemical differences among five South Transverse sections of leaf, stem, barks were under a microscope elucidate differences. Stem exhibited characteristic medullary ray secretary canal size. Leaf surface, petiole,...

Amanita hemibapha subsp. javanica (Amanitaceae) is an edible Korean wild mushroom. A. often confused with subjunquillea, known as the East Asian death cap, which potentially fatal when ingested. This study aimed to conduct first chemical investigation of javanica, resulted in isolation seven fatty acid derivatives (1-7) and three steroids (8-10) from MeOH extract its fruiting bodies, their structures were determined by comparing NMR spectroscopic data those previously reported, along LC/MS....