A5103068928- Cancer Genomics and Diagnostics
- Breast Cancer Treatment Studies
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- HER2/EGFR in Cancer Research
- Radiomics and Machine Learning in Medical Imaging
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Galectins and Cancer Biology
- Diabetic Foot Ulcer Assessment and Management
- Cancer Risks and Factors
- Medical Imaging and Pathology Studies
- Ethics in Clinical Research
- NF-κB Signaling Pathways
- Neurofibromatosis and Schwannoma Cases
- Chronic Myeloid Leukemia Treatments
- Prostate Cancer Treatment and Research
- Genomics, phytochemicals, and oxidative stress
- Biomedical Ethics and Regulation
- Breast Lesions and Carcinomas
- Immunotherapy and Immune Responses
- Pressure Ulcer Prevention and Management
- Metastasis and carcinoma case studies
- Cell death mechanisms and regulation
- Wound Healing and Treatments
Adnan Menderes University
2007-2024
Dokuz Eylül University
2013-2022
Adıyaman University
2015
Clear cell renal carcinoma (ccRCC) is the most frequently encountered tumor in adult kidney. Many factors are known to take part development and progression of this tumor. Nuclear factor kappa B (NF-κB) a family genes that includes five members acting events such as inflammation apoptosis. In study, role NF-κB (p50 subunit) ccRCC its relation angiogenesis apoptosis were investigated. Formalin-fixed paraffin embedded tissue blocks from 40 patients with studied. Expressions (p50), VEGF, EGFR,...
The prognosis of metastatic gastric cancer is poor. Despite the use VEGF-, EGFR-, and HER2-targeting agents, still poor in advanced cancer. Although immunotherapy responds well some patients, clinical limited due to unanswered patients. For this reason, it necessary know characteristics primary cells for patient selection additional criteria are required. MHC-1 downregulation most frequently observed tumor escape mechanism from immune system. with increased PDL-1 expression has an important...
Menopausal status affects the prognoses and consequences of breast cancer. Therefore, this retrospective study aimed to reveal molecular variation profile differences in cancer patients according their menopausal status, with hypothesis that profiles will be different at premenopausal postmenopausal ages. Breast (n = 254) who underwent subtyping QIAseq Human Cancer NGS Panel screening between 2018 2022 were evaluated retrospectively. Their was defined by age, those aged 50 years above...
We aimed to evaluate the findings and results from breast magnetic resonance imaging (MRI) examinations performed for problem-solving purposes due inconclusive conventional findings.Imaging findings, biopsy follow-up were retrospectively evaluated MRI at our department between January 2011 December 2016 cases whose mammography, tomosynthesis, or ultrasonography inconclusive.Lesions identified in 414 of 986 examinations, 13.3% these lesions diagnosed as malignant. A total 124 additionally...
Colorectal cancer (CRC) is the third most frequent malignancy. Many factors such as NF-κB, matrix metalloproteinase-1 (MMP-1), p53, and Ki-67 are likely to be involved in its development progression. Lymph node metastases indicate increased tumor burden cell heterogeneity affect both treatment strategies prognosis. In this study, expressions of MMP-1, were between primary tumors lymph 110 Dukes' stage C, CRC cases by immunohistochemical methods, related patients' clinical outcomes....
ABSTRACT Background: The co-occurrence of lung adenocarcinoma and brain metastasis remains a significant cause morbidity mortality despite advancements in cancer treatment. activity neurofibromin, the product Neurofibromatosis Type 1 gene (NF1) , is crucial regulating RAS/MAPK pathway. NF1 somatic mutations are conditions such as melanoma, cancer, breast neuroblastoma, central nervous system tumors. Objective: Therefore, this research aims to uncover profile co-mutations patients with...
Prostate cancer is a common in males, frequently leading to mortality. Multiple genetic factors play roles prostate pathogenesis. Demonstration of pathological pathways and customised treatment options have been possible with next-generation sequencing.
Tuberculosis osteomyelitis is rarely seen in the diaphyseal bones. It may be confused with Brodie's abscess due to similar clinical, radiological and laboratory findings. Late diagnosis of disease causes bone destruction. a rare condition caused by Mycobacterium tuberculosis. Its incidence has increased Western countries recent years HIV infection, increasing elderly population emerging resistant strains. The slow progress tuberculous osteomyelitis, lack significant elevations values changes...
Introduction Absence of mismatch repair (MMR) genes in tumor cells or errors the replication process may lead to DNA-MMR deficiency and microsatellite instability (MSI) formation. Specific environments where gene variations are observed believed be conducive formation MSI. This study aimed determine MSI status, MMR protein expression, somatic mutation profile solid organ tumors. Material methods In this study, records 192 patients with tumors who were referred Molecular Pathology Laboratory...
Recent studies that reveal the molecular profiles of colorectal carcinomas have demonstrated tumor heterogeneity. Characterization carcinoma-specific genomic alterations is essential for developing more successful and targeted treat- ment protocols. Moreover, it vital in elucidating pathogenesis mechanisms resistance against treatment predicting prognosis.The study included 73 cases diagnosed with subjected to analysis by next-generation sequencing. The association between clinicopathologic...
Background: Flow cytometry is one of the classical diagnostic tools used in diagnosis AML. In particular, use these two methods essential for minimally measurable disease. According to our current knowledge, there only study literature that evaluated expression surface markers detected by both NGS and flow cytometry. this study, NPM1, FLT3 (TKD ITD), KRAS NRAS signal mutations were found be associated with high CD33 levels Aims: we aimed determine relationship between cytometrically...