A5071416138- Reproductive Biology and Fertility
- Multiple Myeloma Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Reproductive Health and Technologies
- SARS-CoV-2 and COVID-19 Research
- CAR-T cell therapy research
- Ovarian function and disorders
- Peptidase Inhibition and Analysis
- Pluripotent Stem Cells Research
- Protein Degradation and Inhibitors
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Acute Myeloid Leukemia Research
- Renal and related cancers
- Quinazolinone synthesis and applications
- Chronic Myeloid Leukemia Treatments
Icahn School of Medicine at Mount Sinai
2024
Tisch Hospital
2024
GameDesk
2024
Rutgers, The State University of New Jersey
2022
Hackensack University Medical Center
2022
Background Autologous stem cell transplantation (ASCT) after induction therapy improves disease-free survival for patients with multiple myeloma (MM). While the goal of ASCT is to render a minimal disease state, it also associated eradication immunosuppressive cells, and we hypothesize that early introduction immunotherapy post-ASCT may provide window opportunity boost treatment efficacy. Methods We conducted phase 1 clinical trial investigate application autologous lymphocyte infusion...
Human induced pluripotent stem cells (hiPSCs) show great promise in the development of novel strategies to mitigate reproductive diseases and promote successful outcomes. Recently, a approach for fast efficient differentiation ovarian support (OSCs) generate versatile platform basic research clinical applications was demonstrated. This study details process application an OSC product, known as Fertilo, improve vitro maturation (IVM) human oocytes, method referred OSC-IVM. First,...
Determine if the gene expression profiles of ovarian support cells (OSCs) and cumulus-free oocytes are bidirectionally influenced by co-culture during in vitro maturation (IVM).
ABSTRACT Objective To evaluate how minimal controlled ovarian stimulation (COS) for in vitro maturation (IVM) affects subjects’ oocyte retrieval experiences compared to conventional COS, considering side effects Design Retrospective Survey Study Setting Clinical fertilization (IVF) treatment centers Spain and the United States. Subjects Data were collected from subjects undergoing COS (n=110; 600-800 IU FSH) IVM egg donation (n=48; 2000-3000 April 2022 November 2023. In same period, a...
Abstract In vitro maturation (IVM) is an infertility treatment used during in fertilization (IVF) procedures which immature oocytes are matured outside the body, limiting excessive hormone doses required for retrieval of ready-to-fertilize oocytes. To overcome historically low embryo formation rate associated with IVM, we have recently demonstrated that co-culture hiPSC-derived ovarian support cells (OSCs) yielded higher rates oocyte and euploid formation, by mimicking complex environment...
To evaluate oocyte retrieval experiences and side effects under minimally controlled ovarian stimulation (COS) treatment for in vitro maturation (IVM) of oocytes compared with conventional COS treatment.
Cytogenetic analysis is important for stratifying patients with various neoplasms. We explored the use of targeted next generation sequencing (NGS) in detecting chromosomal structural abnormalities or copy number variations (CNVs) myeloid neoplasms.Plasma cell-free DNA (cfDNA) from 2821 lymphoid neoplasm were collected. cfDNA was sequenced using a 275 gene panel. CNVkit software used analyzing and visualizing CNVs. data corresponding bone marrow (BM) samples available on 89 samples.Of...
Patients with hematologic malignancies have poor outcomes from COVID infection and are less likely to mount an antibody response after infection. This is a retrospective study of adult lymphoma patients who received the vaccine between 12/1/2020 11/30/2021. The primary endpoint was positive anti-COVID spike protein level following vaccination series. series defined as 2 doses mRNA vaccines or 1 dose adenovirus vaccine. Subgroups were compared using Fisher’s exact test, unadjusted adjusted...
Abstract Study question Are the gene expression profiles of ovarian support cells (OSCs) and cumulus-free oocytes bidirectionally influenced by co-culture during in vitro maturation (IVM)? Summary answer OSC is modulated oocyte presence OSC-IVM matured display transcriptomic resemblance to vivo potentially due OSC-oocyte crosstalk. What known already The application IVM holds a significant interest improve infertility treatment. We previously showed development human OSCs generated from...
Abstract Patients with hematologic malignancies have poor outcomes from COVID infection and are less likely to mount an antibody response after infection. There is limited data on the efficacy of vaccines in lymphoma patients, suggest optimal timing vaccination elicit immunity patients receiving immunochemotherapy. This a retrospective study adult who received vaccine between 12/1/2020 11/30/2021. The primary endpoint was positive anti-COVID spike protein titer following series. series...