A5101971919- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- CAR-T cell therapy research
- SARS-CoV-2 and COVID-19 Research
- Botulinum Toxin and Related Neurological Disorders
- Vitamin D Research Studies
- Bioactive Natural Diterpenoids Research
- Bone health and treatments
- Dermatologic Treatments and Research
- Parkinson's Disease Mechanisms and Treatments
- Plant-based Medicinal Research
- Cancer Immunotherapy and Biomarkers
- Traditional Chinese Medicine Analysis
- Immunotherapy and Immune Responses
- Medicinal Plant Pharmacodynamics Research
- Phytochemistry and Bioactive Compounds
- Biomarkers in Disease Mechanisms
- HER2/EGFR in Cancer Research
- Phytochemistry and Biological Activities
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- S100 Proteins and Annexins
- Neurological disorders and treatments
- Medicinal Plants and Bioactive Compounds
- Sodium Intake and Health
- Ginseng Biological Effects and Applications
Dalian Medical University
2017-2025
Second Affiliated Hospital of Dalian Medical University
2017-2025
Foshan Maternity and Child Health Care Hospital
2024
Hainan Normal University
2024
Guangdong Medical College
2010-2024
Central People's Hospital of Zhanjiang
2024
Georgetown University
2021-2022
Chinese Academy of Sciences
2021-2022
China Pharmaceutical University
2022
University of Chinese Academy of Sciences
2022
While highly efficacious in treating rheumatoid arthritis (RA), the approved Janus kinase (JAK) inhibitor, Tofacitinib (Tofa, CP-690 550), has dose-dependent toxicities that limit its clinical application. In this study, we have examined whether a prodrug design targets arthritic joints would enhance Tofa's therapeutic efficacy, which may provide an opportunity for future development of safer Tofa dosing regimens. A (P-Tofa) was synthesized by conjugating drug to...
Secondary osteoporosis is frequently due to the use of high-dose glucocorticoids (GCs). The existing strategy for managing glucocorticoid-induced (GIOP) considered insufficient and remains in a state ongoing evolution. Therefore, it crucial develop more precise effective agents treatment GIOP. constituents
Senile osteoporosis (SOP) is a systemic bone disease characterized by increased susceptibility to fractures. However, there currently no effective treatment for SOP. The Zhuangyao Jianshen Wan (ZYJSW) pill traditionally believed possess kidney-nourishing and bone-strengthening effects, demonstrating efficacy in treating Despite this, its effectiveness mechanism SOP remain unclear. This study aims investigate the therapeutic potential of ZYJSW senescence accelerated mouse prone 6 (SAMP6, P6)...
Osteopenia and skeletal fragility are considered to be the complications associated with type 2 diabetes mellitus (T2DM). The relationship between glucose metabolism, quality, vitamin D have not been completely understood. We aimed demonstrate a comprehensive bone quality profile in T2DM model subject investigate whether 1, 25-dihydroxy D3 could prevent osteopenia rats. Daily calcitriol (a formulation, 0.045 μg/kg/day) treatment was administered 21-week-old male Goto-Kakizaki (GK) rats...
Patients with hematologic malignancies have poor outcomes from COVID infection and are less likely to mount an antibody response after infection. This is a retrospective study of adult lymphoma patients who received the vaccine between 12/1/2020 11/30/2021. The primary endpoint was positive anti-COVID spike protein level following vaccination series. series defined as 2 doses mRNA vaccines or 1 dose adenovirus vaccine. Subgroups were compared using Fisher’s exact test, unadjusted adjusted...
Vitamin D modulates about 3% human gene transcription besides the classical action on calcium/phosphorus homeostasis. The blood pressure-lowing and other protective cardiovascular disease have been reported. present study aims to examine whether COX-1 COX-2 were implicated in endothelial dysfunction hypertension calcitriol, an active form of vitamin preserved function through regulating COX expression. Isometric demonstrated impaired endothelium-dependent relaxation (EDR) renal arteries from...
The chemical constituents from the stems and leaves of Mycetia hainanensis were isolated by silica gel, ODS Sephadex LH-20 gel column chromatography preparative HPLC. structures all compounds identified on basis their physicochemical properties, spectroscopic data, as well comparison data with reported in literature. Twelve 85% ethanol extract M. hainanensis, they mycehainanic acid(1), 11-methoxyviburtinal(2), isovaltrate acetoxyhydrin(3), jatamanvaltrate K(4), jatamanin C(5), sarmentol...
Abstract Patients with hematologic malignancies have poor outcomes from COVID infection and are less likely to mount an antibody response after infection. There is limited data on the efficacy of vaccines in lymphoma patients, suggest optimal timing vaccination elicit immunity patients receiving immunochemotherapy. This a retrospective study adult who received vaccine between 12/1/2020 11/30/2021. The primary endpoint was positive anti-COVID spike protein titer following series. series...
Objective This study aimed to investigate early brain microstructural changes discovered using magnetization-prepared two rapid acquisition gradient echo (MP2RAGE) sequence and cerebral hemodynamic TCD for cognitive impairment after acute infarction. Methods We enrolled 43 patients with infarction 21 healthy people in the study, who were subjected assessments, MP2RAGE sequence, a examination. A total of 26 regions interest investigated. Furthermore, we used hemodynamics explain changes,...
This study aimed to assess the effects of total flavonoid extracts (TFDG) and monomers Daphne genkwa on CYP2C8 activity in vitro vivo.The 50% inhibitory concentration (IC50) values were used determine effect TFDG its four for by recombinant human (RHCYP2C8) yeast microsome system vitro, volume per dose index (VDI) was predicted potential inhibition vivo. The multiple-dose administration pharmacokinetic parameters rosiglitazone rats evaluated.The IC50 apigenin, luteolin, hydroxy-genkwanin,...