A5075685892- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Porphyrin and Phthalocyanine Chemistry
- Graphene and Nanomaterials Applications
- Carbon and Quantum Dots Applications
- Nanoparticles: synthesis and applications
- Nanoparticle-Based Drug Delivery
- Photoacoustic and Ultrasonic Imaging
- Ultrasound and Hyperthermia Applications
- Force Microscopy Techniques and Applications
- Nanocluster Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- bioluminescence and chemiluminescence research
- Nematode management and characterization studies
- Skin Protection and Aging
- Healthcare and Environmental Waste Management
- Spectroscopy Techniques in Biomedical and Chemical Research
- thermodynamics and calorimetric analyses
- RNA Interference and Gene Delivery
- Bone Tissue Engineering Materials
- Essential Oils and Antimicrobial Activity
- Plant Virus Research Studies
- Microplastics and Plastic Pollution
- Ultrasound and Cavitation Phenomena
- Gold and Silver Nanoparticles Synthesis and Applications
Palacký University Olomouc
2013-2024
Central Institute for Supervising and Testing in Agriculture
2018-2023
Institute of Molecular and Translational Medicine
2012-2022
State Phytosanitary Administration
2010-2014
Regional Centre of Advanced Technologies and Materials
2012
Photodynamic therapy is usually used against malignant and non-malignant tumors. Nowadays, due to resistance of bacterial strains, we are looking for a new antimicrobial strategy destroy bacteria with minimal invasive consequences. The worldwide increase in antibiotic among different classes gram-positive gram-negative has led the search alternative anti-microbial therapies such as PDT (aPDT). Development technology combines nontoxic compound, called photosensitizer, visible light...
Cationic quaternized carbon dots (QCDs) and anionic graphene oxide sheets (GO) are combined via non-covalent interactions following a self-assembly pathway to form highly biocompatible fluorescent hybrid materials. These hybrids act as selective probes with controlled labelling of the cell nucleus or cytoplasm depending on QCD loading.
In vitro cytotoxicity analysis of doxorubicin-loaded/superparamagnetic iron oxide colloidal nanoassemblies on MCF7 and NIH3T3 cell lines Katerina Tomankova,1 Polakova,2 Klara Pizova,1 Svatopluk Binder,1 Marketa Havrdova,2 Mary Kolarova,2 Eva Kriegova,3 Jana Zapletalova,1 Lukas Malina,1 Horakova,1 Jakub Malohlava,1 Argiris Kolokithas-Ntoukas,4 Aristides Bakandritsos,4 Hana Kolarova,1 Radek Zboril2 1Department Medical Biophysics, Institute Translation Medicine, Faculty Medicine Dentistry,...
Clustering of biocompatible magnetic iron oxide nanocrystallites (MIONs) is a synthetic strategy which improves manipulation, imaging, and sensing for biomedical applications. In this work we describe the synthesis condensed clustered MIONs obtained through biomineralization epitaxial aggregation in presence alginate at ambient conditions, mimicking process that so far has been achieved only by nature, iron-oxidizing bacteria. These condensed-type nanostructures exhibit higher...
Core–shell hydrophilic superparamagnetic iron oxide (SPIO) nanoparticles, surface functionalized with either terephthalic acid or 2-amino acid, showed large negative MRI contrast ability, validating the advantage of using low molecular weight and π-conjugated canopies for engineering functional nanostructures superior performances.
It is important to understand the nanomaterials intracellular trafficking and distribution investigate their targeting into nuclear area in living cells. In our previous study, we firstly observed penetration of nonmodified positively charged carbon dots decorated with quaternary ammonium groups (QCDs) nucleus mouse NIH/3T3 fibroblasts. Thus, this work, focused on deeper study QCDs inside two healthy L929 cell lines by fluorescence microspectroscopy performed a comprehensive cytotoxic DNA...
In 2009 a new three year EU funded project (QBOL) started on DNA barcoding of important plant pests. An international consortium 20 partners (universities, research institutes, and phytosanitary organizations) from around the world, coordinated by Plant Research International (Wageningen, Netherlands), will collect barcodes many pathogenic quarantine organisms, store these sequences in database accessible over internet, develop bank train end‐users. All activities should help National...
Several recent studies bring evidence of cell death enhancement in photodynamic compound loaded cells by ultrasonic treatment. There are a number hypotheses suggesting the mechanism harmful effect. One them considers process activation photosensitizers energy. Because basis damaging effect on consists production reactive oxygen species (ROS), we focused our study whether ultrasound can increase ROS within cancer cells. Particularly, studied formation pretreated breast adenocarcinoma during...
The modification of implant surface situated in the area peri‐implant sulcus has important role bacterial and cell adhesion. Six different chemically physically modified titanium discs were prepared: glazed (Tis‐MALP), unglazed (Tis‐O), alkali‐etched (Tis‐OA), coated with ZrN (Tis‐OZ), unglazed, sand blasted, acid etched (Tis‐OPAE), acid, alkali (Tis‐OPAAE). Analysis topography was determined using scanning electron microscopy atomic force (AFM). Biocompatibility gingival fibroblasts...