Of all of the epithelial ovarian cancers, clear cell carcinoma (CCC) ovary has worst prognosis. We applied oligonucleotide array technique to identify genes generally involved in CCC. ∼12,600 that were analyzed, 28 expressed significantly differently between four CCC and seven non-CCC lines. Among 16 up-regulated CCC, we further investigated a transcription factor, hepatocyte nuclear factor-1β (HNF-1β). validated up-regulation HNF-1β terms both mRNA protein level using real-time quantitative...

No AccessJournal of Urology1 Jul 1983Hematoporphyrin Derivative and Laser Photoradiation in the Diagnosis Treatment Bladder Cancer Akira Tsuchiya, Nobuo Obara, Makoto Miwa, Tetsutaro Ohi, Harubumi Kato, Yoshihiro Hayata TsuchiyaAkira Tsuchiya More articles by this author , ObaraNobuo Obara MiwaMakoto Miwa OhiTetsutaro Ohi KatoHarubumi Kato HayataYoshihiro View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)50965-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack...

Zwitterionic polymer PMPC was conjugated to a DNA aptamer enhance its therapeutic efficacy in vivo , while minimizing the recognition by anti-PEG antibodies.

To evaluate the TRUCLEAR™ system (Smith and Nephew Inc., London, UK), a hysteroscopic that morcellates aspirates masses, in terms of operating time, surgeon's convenience, effect on patients compared with conventional electrosurgical resection.Patients undergoing resection endometrial polyps were randomly allocated to undergo morcellation or (UMIN-CTR identifier: UMIN000019649). The primary outcome was time. Secondary outcomes removal success, fluid deficit, convenience technique, insertion...

This paper proposes a set of monitor circuits to estimate global process variations in post-silicon. Ring oscillators (ROs) are chosen as where ROs designed have enhanced sensitivities variations. The proposed technique extracts parameter from RO outputs. An iterative estimation method is also developed correctly under the presence nonlinearity outputs Simulation results show that robust against uncertainties such measurement error. A test chip 65-nm has been fabricated validate circuits....

Abstract Dysadherin is a membrane glycoprotein expressed strongly in several human cancers. Overexpression of dysadherin tumor cells closely associated with malignant phenotype (e.g., metastasis) and poor prognosis. In our analysis, six pancreatic cancer cell lines showed positive correlation between expression motility. Introduction small interfering RNA (siRNA) against into the Panc-1 line caused reduction suppression contrast, stable transfection vector Capan-1 increased vivo, metastatic...

A body bias generator (BBG) for fine-grain biasing (FGBB) that can operate under wide supply-range is proposed. While FGBB effective in reducing variability and power consumption, a number of BBGs are required on die therefore simplified design necessary. This paper proposes cell-based BBG generates forward reverse voltages only from core supply voltage ranging the near threshold 500mV to nominal 1.2V. operating range achieved by low error amplifier with V <sub...

We evaluated the clinical usefulness and safety of transradial approach for transcatheter arterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC) compared that conventional transfemoral approach. The two groups (radial group, n = 177; femoral 150) cases were retrospectively regard to successful rate angiography or TACE, time required catheterizaiton complications. Hepatic TACE completed 174 (98.3%) 177 radial group. There was no intergroup difference...

The brain is composed of many different types neurons. Therefore, analysis activity with single-cell resolution could provide fundamental insights into mechanisms. However, the electrical signal an individual neuron very small and precise isolation single neuronal from moving subjects still challenging. To measure single-unit signals in actively behaving states, establishment technologies that enable fine control electrode positioning strict spike sorting essential. further apply such a...

In this paper, we propose a multistage transimpedance amplifier (TIA) based on the local negative feedback technique. Compared with conventional global-feedback technique, proposed TIA has advantages of wider bandwidth, and lower power dissipation. The schematic characteristics circuit are described. Moreover, employs inductive peaking to increase bandwidth. is implemented using 65 nm complementary metal oxide semiconductor (CMOS) technology consumes 23.9 mW supply voltage 1.0 V. Using...

We propose a set of variation-sensitive ring oscillators (RO) to estimate Die-to-Die process parameter variation. ROs are designed have different sensitivity each A method suitable variation from is proposed. fabricated test chip and successfully estimated Variation results correlated with that in Process Control Module data.

Background: In decompensated liver cirrhosis, hypoalbuminemia still persists even after they have been treated with branched-chain amino acid (BCAA) granules. We prospectively evaluated whether BCAA enriched nutrient switched from granules would increase the serum albumin level, and consequently extend survival time hepatocellular carcinoma (HCC) treatment. Methods: This study included 77 patients for cirrhosis HCC. After nutritional assessment, all initially received unchanged or decreased...

A body bias generator (BBG) for fine-grain biasing (FGBB) compatible with cell-based design How is proposed. The FGBB effective to reduce variability and power consumption in a system-on-chip (SoC). Since needs number of BBGs, automated BBGs required. This paper proposes the BBG implement by partitioning into unit-height cells. Circuit configuration enables wide range supply voltage from 0.6V 1.2V. We fabricated 65nm CMOS process control 0.1mm <sup...

To reduce intraoperative blood loss in laparoscopic myomectomy, uterine artery occlusion or temporary clipping have been employed. Recently, addition to these techniques, ligation has reported as a new method that less invasive effects on fertility and needs no special devices be used. This study aimed evaluate the effect of minimize during myomectomy.This was retrospective case-control at department Obstetrics Gynaecology, University Hospital Mizonokuchi, Teikyo School Medicine. A total 264...

To compensate the die-to-die and location correlated variation, we propose to split digital circuit sub-mm-scale area controlling each with an on-chip forward/reverse body bias generator (BBG). The proposed BBG is configured as a feedforward control system achieve small area. realized by combining low output resistance DAC charge pump type level shifter. design implemented 1.2V thin gate oxide MOSFET in 65nm CMOS technology. simulation measurement results show that variation compensated overhead 2%.

We propose a low-power and compact 25-Gb/s differential CMOS modulator driver. To achieve low power consumption, we employ an output driver with high-gain single-stage amplifier gainless pre-driver equalizer function. In the pre-driver, use area-efficient 3D inductors for inductor peaking technique to obtain function compactness. also cascode consisting of high-voltage standard MOSFETs large voltage swing in technology. The proposed was fabricated 65-nm 1P9M CMOS. It exhibits data rate 25...

This paper investigates the impact of size effect and anomalous skin in on-chip interconnects under cryogenic environment. Cryo-CMOS technology is required for quantum computers. At temperature, electron-mean-free-path becomes longer surface scattering dominant factor to determine resistivity. Also, affects frequency characteristics. I investigate by evaluating considering scattering. Numerical evaluation reveals that size-dependency resistivity have be taken into consideration.

Purpose: We report on a case of extragonadal germ cell tumor the prostate associated with Klinefelter’s syndrome. Methods/Results: The patient was 33‐year‐old man. A transrectal biopsy suggested combined (yolk sac + teratoma). Because there no except from prostate, we considered this to be primary prostate. responded systemic chemotherapy cisplatin, vinblastine and bleomycin elevated lactate dehydrogenase α‐fetoprotein levels normalized. In addition chemotherapy, also underwent radiation...

To address the performance limitation brought by scaling issues of on-chip global wires, a new configuration for wiring using lossy transmission lines is proposed and optimized. We propose signaling structure to compensate distortion attenuation lines, which uses passive compensation inserts repeated transceivers composing sense amplifiers inverter chains. An optimization flow designing this scheme based on eye-diagram prediction sequential quadratic programming (SQP) devised. This used...