A5090891751- RNA modifications and cancer
- Neuroscience and Neuropharmacology Research
- RNA and protein synthesis mechanisms
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Signaling Pathways in Disease
- Calpain Protease Function and Regulation
- RNA regulation and disease
- DNA Repair Mechanisms
German Centre for Cardiovascular Research
2023
Universitätsmedizin Göttingen
2021-2022
University of Göttingen
2022
Abstract Calpains are calcium-activated neutral proteases involved in the regulation of key signaling pathways. Junctophilin-2 (JP2) is a Calpain-specific proteolytic target and essential structural protein inside Ca 2+ release units required for excitation-contraction coupling cardiomyocytes. While downregulation JP2 by Calpain cleavage heart failure has been reported, precise molecular identity sites (patho-)physiological roles products remain controversial. We systematically analyzed...
The highly conserved YrdC domain-containing protein (YRDC) interacts with the well-described KEOPS complex, regulating specific tRNA modifications to ensure accurate synthesis. Previous studies have linked complex a role in promoting telomere maintenance and controlling genome integrity. Here, we report on newborn severe neonatal progeroid phenotype including generalized loss of subcutaneous fat, microcephaly, growth retardation, wrinkled skin, renal failure, premature death at age 12 days....
In the heart, genetic or acquired mishandling of diastolic [Ca 2+ ] by ryanodine receptor type 2 (RyR2) overactivity correlates with risks arrhythmia and sudden cardiac death. Strategies to avoid these include decrease Ca release drugs modulating RyR2 activity increase in uptake SR ATPase (SERCA2a) activity. Here, we combine strategies developing experimental compounds that act simultaneously on both processes. Our screening efforts identified new 1,4-benzothiazepine derivative GM1869 as a...