A5006405741- Cellular Mechanics and Interactions
- Genomics and Chromatin Dynamics
- DNA Repair Mechanisms
- Wound Healing and Treatments
- Immune cells in cancer
- Genetics and Neurodevelopmental Disorders
- Planarian Biology and Electrostimulation
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Cell Adhesion Molecules Research
- Immune Response and Inflammation
- CRISPR and Genetic Engineering
- Lymphatic System and Diseases
- Neuroendocrine Tumor Research Advances
The Wallace H. Coulter Department of Biomedical Engineering
2020-2023
Georgia Institute of Technology
2020-2023
Salk Institute for Biological Studies
2020-2021
DNA repair within neurons Humans have only a limited capacity to generate new neurons. These cells thus need errors in the genome. To better understand this process, Reid et al. developed Repair-seq, method locate genome of stem cell–derived hotspots (DRHs) were more likely occur specific genomic features such as gene bodies well formations, open chromatin, and active regulatory regions. This showed that was enriched at sites involved neuronal function identity. Furthermore, proteomic data...
Local biomaterial-mediated delivery of PD-L1 induces alloislet graft survival and function in a murine model type 1 diabetes.
Understanding the immune response to hydrogel implantation is critical for design of immunomodulatory biomaterials. To study progression inflammation around poly(ethylene glycol) hydrogels presenting Arg-Gly-Asp (RGD) peptides and vascular endothelial growth factor, we used temporal analysis high-dimensional flow cytometry data paired with intravital imaging, immunohistochemistry, multiplexed proteomic profiling. RGD-presenting created a reparative microenvironment promoting CD206 + cellular...
Abstract Neurons are the longest-living cells in our bodies, becoming post-mitotic early development upon terminal differentiation. Their lack of DNA replication makes them reliant on repair mechanisms to maintain genome fidelity. These decline with age, potentially giving rise genomic dysfunction that may influence cognitive and neurodegenerative diseases. Despite this challenge, knowledge how instability emerges what neurons other long-lived have evolved protect their integrity over human...
Purpose - Wound care following surgical procedures involves careful management, reducing risk of infection, and maximizing tissue oxygenation. Even with new strides in biological synthetic products, achieving adequate wound remains an important topic interest. In this study, we develop injectable hydrogel to promote resolution while increasing polarization immune subsets towards healing phenotypes. These poly(ethylene glycol)-maleimide (PEG-MAL) hydrogels are capable locally delivering...