A5039093947- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Diseases and Immunity
- Liver Disease and Transplantation
- Diet, Metabolism, and Disease
- Systemic Lupus Erythematosus Research
- Nutrition and Health in Aging
- Drug-Induced Hepatotoxicity and Protection
- HIV/AIDS drug development and treatment
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Body Composition Measurement Techniques
- Hepatitis Viruses Studies and Epidemiology
- Renal Diseases and Glomerulopathies
- Systemic Sclerosis and Related Diseases
- Tuberculosis Research and Epidemiology
- Diet and metabolism studies
- Alcohol Consumption and Health Effects
- Amoebic Infections and Treatments
- Platelet Disorders and Treatments
- Complement system in diseases
- Chronic Lymphocytic Leukemia Research
- Cytomegalovirus and herpesvirus research
- Diabetes Treatment and Management
National and Kapodistrian University of Athens
2016-2025
Hippocration General Hospital
2012-2025
New York Institute of Technology
2025
Athens Euroclinic
2024
North Carolina Exploring Cultural Heritage Online
2024
401 General Military Hospital of Athens
2023
Laiko General Hospital of Athens
2016
Ospedale Maggiore
2016
New York University
2015
Creative Commons
2013
Information is presented from 555 patients with Dukes B and C rectal cancers treated by curative resection who were entered into the National Surgical Adjuvant Breast Bowel Project (NSABP) protocol R-01 between November 1977 October 1986. Their average time on study was 64.1 months. The randomized to receive no further treatment (184 patients), postoperative adjuvant chemotherapy 5-fluorouracil, semustine, vincristine (MOF) (187 or radiation therapy patients). group, when compared group...
Powerful digital grasping is essential for primates navigating arboreal environments and often regarded as a defining characteristic of the order. However, in vivo data on primate grip strength are limited. In this study, we collected from hands feet eleven strepsirrhine species to assess how ecomorphological variables-such autopodial shape, laterality, body mass locomotor mode-influence performance. Additionally, derived anatomical estimates force cadaveric material determine whether ex...
Abstract Lifestyle interventions remain the cornerstone therapy for non-alcoholic fatty liver disease (NAFLD). This randomised controlled single-blind clinical trial investigated effect of Mediterranean diet (MD) or lifestyle, along with weight loss, in NAFLD patients. In all, sixty-three overweight/obese patients (50 ( sd 11) years, BMI=31·8 4·5) kg/m 2 , 68 % men) ultrasonography-proven (and elevated alanine aminotransferase (ALT) and/or γ-glutamyl transpeptidase (GGT) levels) were to...
Necroptosis is a recently described Caspase 8-independent method of cell death that denotes organized cellular necrosis. The roles RIP1 and RIP3 in mediating hepatocyte from acute liver injury are incompletely defined. Effects necroptosis blockade were studied by separately targeting diverse murine models injury. Blockade had disparate effects on disease outcome depending the precise etiology component necrosome targeted. In ConA-induced autoimmune hepatitis, deletion was protective, whereas...
The prevalence of antithyroid peroxidase antibodies (ATPO) and/or thyroid dysfunction was studied in 422 patients with chronic viral hepatitis C, B, and D. Baseline results were compared those during 6 months after interferon alfa (IFN-α) therapy. overall ATPO among untreated 14.1%, no significant differences between or D, as well males females. However, high titers (≥ 18 IU/mL) clustered significantly females (8.7% vs. 3.4%; P = .022), especially C (11.2% 3.6%; .036). Before treatment, 3.7%...
The impedance to blood flow was examined by transvaginal color imaging in 53 ovarian masses before exploratory laparotomy. Serum CA 125 levels were measured all subjects. Thirty-six had benign tumors and 17 malignant confirmed histopathologic examination. Intratumoral vessels, detected 16 of the tumors, consistently demonstrated low flow, with a pulsatility index (PI) always below 1. PI intraovarian or intratumoral vessels greater than 1 35 36 although 11 suspicious sonographic findings (P...
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies worldwide, while it persists as fourth most prevalent cause cancer-related death in United States America. Although there are several novel therapeutic strategies for approach this intensely aggressive tumor, remains a clinical challenge, hard to identify early stages, due its asymptomatic course. A diagnosis usually established when disease already late chemoresistance constitutes an obstacle optimal management...
Malnutrition risk screening in cirrhotic patients is crucial, as poor nutritional status negatively affects disease prognosis and survival. Given that a variety of malnutrition tools usually used routine clinical practice, the effectiveness eight detecting was sought. A total 170 (57·1 % male, 59·4 (sd 10·5) years, 50·6 decompensated ones) with cirrhosis various aetiologies were enrolled. Nutritional performed using Universal Screening Tool, Risk Index, (NRS-2002), Birmingham Score, Short...
Newer advances involving immunotherapies are changing the hepatocellular carcinoma (HCC) landscape. In multinational OPAL study, we described characteristics of patients with HCC during 2014-2021 in Greece. This was a retrospective chart review study adults (alive/dead) newly diagnosed between 2014-2021. Of 406 patients, 37.7%, 33.0%, 25.9% and 3.4% had Barcelona Clinic Liver Cancer (BCLC) stage 0/A, B, C D, respectively. Common etiologies were hepatitis B virus (32.9%), alcohol use (31.6%),...
Intravenous methylprednisolone (IVMP) pulses, widely used for managing multiple sclerosis (MS) exacerbations, can lead to acute liver injury, presenting a diagnostic challenge in distinguishing between drug-induced autoimmune-like hepatitis (DI-ALH) and idiopathic autoimmune (AIH). This study aimed delineate the clinical biochemical features of IVMP-induced discern its etiology, evaluate efficacy glucocorticoid (GC) therapy treatment. A retrospective analysis 13 relapsing MS patients with...
How exon-intron structures of eukaryotic genes evolved under various evolutionary forces remains unknown. The phases spliceosomal introns (the placement with respect to reading frame) provide an opportunity approach this question. When a large number nuclear in protein-coding were analyzed, it was found that most phase 0, which keeps codons intact. We the distribution is strongly correlated sequence conservation splice signals exons; relatively underrepresented 2 are associated lowest...
Background Hepatic granulomas have been reported in 2–15% of unselected liver biopsies, with a wide clinical profile responsible for their presence. To date, no series concerning the prevalence and etiology from Greece has reported. Objectives evaluate hepatic to investigate whether there an alteration distribution diagnoses our compared those published so far literature. Study The results biopsy specimens performed Department Medicine, between 1999 2004, were retrospectively reviewed cases...
Dietary and physical activity (PA) habits have been suggested as important factors for nonalcoholic fatty liver disease (NAFLD). Published data are mainly focused on the effect of either diet or exercise, whereas other aspects like sleep remain sparse. The aim this study was to explore potential associations between dietary intake, PA, sleeping habits, presence NAFLD.One hundred patients with ultrasound-proven NAFLD 55 healthy controls matched age, sex, body mass index were included....
In primary biliary cirrhosis (PBC), the development of hepatocellular carcinoma (HCC) was thought to represent a rare complication. contrast, extrahepatic malignancies have been reported be significantly associated with PBC. The aim this study determine incidence HCC and in large cohort patients PBC.A total 212 documented PBC (19 men 193 women) were followed up for median 6 (range, 1-23) years.In total, 23 (10.8%) cases malignancy diagnosed; eight (3.8%) 15 (7.0%) malignancies. found 10-year...
Goals/Background: Nonalcoholic fatty liver disease (NAFLD) is associated with obesity, but it may also be present in lean individuals. We evaluated the characteristics of NAFLD patients, focusing on those normal body mass index (BMI). Study: One hundred and sixty-two 185 consecutive patients were included. Demographic, clinical, somatometric, laboratory recorded. BMI<25 kg/m2 was considered to normal. Results: Of 162 12% had BMI. Patients compared increased BMI fulfilled more frequently no...
The aim of this study was to evaluate whether ursodeoxycholic acid (UDCA) has any effect on the development liver decompensation and survival patients with primary biliary cirrhosis (PBC).A total 86 compensated PBC were randomly assigned receive UDCA (n = 43) or remain untreated (controls, n 43). There no significant difference in baseline characteristics between two groups. Mean follow-up 7.3 +/- 3.0 yr 8.1 3.1 control group. Fourteen crossed-over therapy after a median 3.5 (range 2-8 yr),...