A5040334266- Autophagy in Disease and Therapy
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Histone Deacetylase Inhibitors Research
- RNA modifications and cancer
- Extracellular vesicles in disease
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genetic factors in colorectal cancer
- Circular RNAs in diseases
- Protein Degradation and Inhibitors
- Hepatocellular Carcinoma Treatment and Prognosis
- Ferroptosis and cancer prognosis
- Ubiquitin and proteasome pathways
- CAR-T cell therapy research
- Colorectal Cancer Treatments and Studies
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- PI3K/AKT/mTOR signaling in cancer
- Hepatitis B Virus Studies
- Gastrointestinal Tumor Research and Treatment
- Angiogenesis and VEGF in Cancer
Evangelismos Hospital
2024-2025
National and Kapodistrian University of Athens
2017-2024
Molecular Oncology (United States)
2019
National Hellenic Research Foundation
2014-2016
Colorectal cancer (CRC) remains a major public health issue. The detection of parameters that affect CRC prognosis is great significance. KRAS mutations, play crucial role in tumorigenesis with strong predictive value. KRAS-mutated stage-IV patients gain no benefit the anti-EGFR therapy. G12C mutation subtype under investigation for treatment regimens. present study aimed to detect various RAS mutations cohort 578 RAS-mutated patients; 49% them had de novo metastatic disease; 60% were male;...
// Maria Goulielmaki 1 , Evangelos Koustas Eirini Moysidou Margarita Vlassi Takehiko Sasazuki 2 Senji Shirasawa 3 George Zografos 4 Eftychia Oikonomou Alexander Pintzas Laboratory of Signal Mediated Gene Expression, Institute Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, Athens, Greece for Advanced Study, Kyushu University, Fukuoka, Japan Department Cell Faculty Medicine, Fukuoka 3rd Surgery, General Hospital Athens G. Gennimatas, Correspondence to:...
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies worldwide, while it persists as fourth most prevalent cause cancer-related death in United States America. Although there are several novel therapeutic strategies for approach this intensely aggressive tumor, remains a clinical challenge, hard to identify early stages, due its asymptomatic course. A diagnosis usually established when disease already late chemoresistance constitutes an obstacle optimal management...
Objectives: Autophagy plays a dual role in tumorigenesis. In the initial stages, it promotes cell survival and suppresses carcinogenesis, whereas cancer development, induces survival. this study, we investigate of autophagy as protective or tumor suppressor mechanism colorectal (CRC) lines evaluate its potential biomarker human samples. Materials Methods: The data 68 patients with CRC treated at our Department from January 1 to December 31, 2016 were analyzed. Immunohistochemistry evaluation...
Background/Aim: Triple negative breast cancer belongs to the most aggressive forms. Histone deacetylases (HDACs) constitute a class of enzymes that exhibit significant role in genesis and progression. In this study, we aimed at assessing clinical importance HDAC-2 triple cancer. Materials Methods: A total 138 specimens were examined on an immunohistochemical basis. statistical analysis was performed order examine association between survival clinicopathological features patients. Results:...
Background/Aim: There is a strong association between malignancy and histone deacetylases (HDACs). Histone deacetylase inhibitors (HDACIs) are now being tested as antitumor agents in various clinical trials. We aimed to assess the importance of HDAC-2 breast cancer (BC). Materials Methods: A total 118 BC specimens were examined immunohistochemically. statistical analysis was conducted order examine relation clinicopathological features survival patients. Results: Higher expression related...