A5063018097- Material Dynamics and Properties
- Salmonella and Campylobacter epidemiology
- Parasites and Host Interactions
- Polymer crystallization and properties
- Rheology and Fluid Dynamics Studies
- Vibrio bacteria research studies
- Bladder and Urothelial Cancer Treatments
- Protein Structure and Dynamics
- Polymer Nanocomposites and Properties
- Immunotherapy and Immune Responses
- Escherichia coli research studies
- nanoparticles nucleation surface interactions
- Theoretical and Computational Physics
- Enzyme Structure and Function
- Bacteriophages and microbial interactions
- Amoebic Infections and Treatments
- Parasitic infections in humans and animals
- Parasite Biology and Host Interactions
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Viral gastroenteritis research and epidemiology
- Phase Equilibria and Thermodynamics
- Polymer Science and PVC
- Helminth infection and control
Stanford University
1984-2021
Jenner Institute
2010-2020
University of Oxford
2010-2020
Columbia College
2015
Simulations Plus (United States)
1997-1998
University of Maryland, College Park
1989-1990
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular dynamics study of melting and freezing small Lennard-Jones clustersJ. Dana. Honeycutt Hans C. AndersenCite this: J. Phys. Chem. 1987, 91, 19, 4950–4963Publication Date (Print):September 10, 1987Publication History Published online1 May 2002Published inissue 10 September 1987https://pubs.acs.org/doi/10.1021/j100303a014https://doi.org/10.1021/j100303a014research-articleACS PublicationsRequest reuse permissionsArticle...
We suggest, using dynamical simulations of a simple heteropolymer modelling the alpha-carbon sequence in protein, that generically folded states globular proteins correspond to statistically well-defined metastable states. This hypothesis, called metastability there are several free energy minima separated by barriers various heights such conformations polypeptide chain each have similar structural characteristics but different energies from one another. The calculated characteristics, as...
The possibility that several metastable minima exist in which the folded forms of a polypeptide chain have similar structural characteristics but different energies is suggested. validity this hypothesis illustrated with aid simulation methods on model protein folds into beta-barrel structure. Some implications such as existence multiple pathways intermediates for folding are discussed.
A sucrose-trehalose glass film dried onto a filter can preserve the activity of two potential live viral vaccine vectors at elevated temperatures for up to 6 months.
We study the kinetics of folding a heteropolymer containing specific sequence hydrophobic, hydrophilic, and neutral residues. The heteropolymer, representing alpha carbon model protein, folds into β-barrel structure below characteristic transition temperature. Several measures are introduced to probe dynamics approach folded state with particular emphasis on formation nonbonded contacts starting from high temperature random configuration. compactness used argue that even temperature, formed...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSmall system size artifacts in the molecular dynamics simulation of homogeneous crystal nucleation supercooled atomic liquidsJ. Dana Honeycutt and Hans C. AndersenCite this: J. Phys. Chem. 1986, 90, 8, 1585–1589Publication Date (Print):April 1, 1986Publication History Published online1 May 2002Published inissue 1 April 1986https://pubs.acs.org/doi/10.1021/j100399a026https://doi.org/10.1021/j100399a026research-articleACS PublicationsRequest reuse...
Salmonella Typhimurium sequence type (ST) 313 causes invasive nontyphoidal (iNTS) disease in sub-Saharan Africa, targeting susceptible HIV+, malarial, or malnourished individuals. An in-depth genomic comparison between the ST313 isolate D23580 and well-characterized ST19 4/74 that gastroenteritis across globe revealed extensive synteny. To understand how 856 nucleotide variations generated phenotypic differences, we devised a large-scale experimental approach involved global gene expression...
The static properties of a polymer molecule in porous medium are investigated. is simulated using site percolation model which the various sites occupied (or unoccupied) randomly. A freely jointed chain allowed to move continuous space between obstacles. Effects excluded volume interactions links have also been studied. Using generalized Flory theory, we shown that, when strength disorder large enough, mean square end-to-end distance scales as N2ν, where N number chain, and ν takes on value...
Most subunit vaccines require adjuvants in order to induce protective immune responses the targeted pathogen. However, many of potent immunogenic display unacceptable local or systemic reactogenicity. Liposomes are spherical vesicles consisting single (unilamellar) multiple (multilamellar) phospholipid bi-layers. The lipid membranes interleaved with an aqueous buffer, which can be utilised deliver hydrophilic vaccine components, such as protein antigens ligands for receptors. Liposomes,...
To prevent important infectious diseases such as tuberculosis, malaria and HIV, vaccines inducing greater T cell responses are required. In this study, we investigated whether fusion of the M. tuberculosis antigen 85A to recently described adjuvant IMX313, a hybrid avian C4bp oligomerization domain, could increase in pre-clinical vaccine model species. mice, fused showed consistent increases CD4(+) CD8(+) after DNA MVA vaccination. rhesus macaques, higher IFN-γ were observed animals...
Sensing and responding to environmental signals is critical for bacterial pathogens successfully infect persist within hosts. Many sense temperature as an indication they have entered a new host must alter their virulence factor expression evade immune detection. Using secondary structure prediction, we identified RNA thermosensor (RNAT) in the 5’ untranslated region (UTR) of tviA encoded by typhoid fever-causing bacterium Salmonella enterica serovar Typhi ( S . Typhi). Importantly,...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTheory for the Phase Behavior of Polyolefin Blends: Application to Polyethylene/Isotactic Polypropylene BlendJohn J. Rajasekaran, John G. Curro, and D. HoneycuttCite this: Macromolecules 1995, 28, 20, 6843–6853Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/ma00124a020https://doi.org/10.1021/ma00124a020research-articleACS PublicationsRequest...
The various sub-species of Salmonella enterica cause a range disease in human hosts. human-adapted serovar Typhi enters the gastrointestinal tract and invades systemic sites to enteric (typhoid) fever. In contrast, most non-typhoidal serovars are primarily restricted gut tissues. Across Africa, invasive (iNTS) have emerged with an ability spread beyond bloodstream infections increased morbidity mortality. To investigate this evolution pathogenesis, we compared genomes African iNTS isolates...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Theoretical Study of Tacticity Effects on Poly(vinyl chloride)/Poly(methyl methacrylate) MiscibilityJ. D. HoneycuttCite this: Macromolecules 1994, 27, 19, 5377–5381Publication Date (Print):September 1, 1994Publication History Published online1 May 2002Published inissue 1 September 1994https://pubs.acs.org/doi/10.1021/ma00097a018https://doi.org/10.1021/ma00097a018research-articleACS PublicationsRequest reuse permissionsArticle...
Background Over 112 million people worldwide are infected with Schistosoma haematobium, one of the most prevalent schistosome species affecting humans. Female genital schistosomiasis (FGS) occurs when S. haematobium eggs deposited into female reproductive tract by adult worms, which can lead to pelvic pain, vaginal bleeding, disfigurement and infertility. Recent evidence suggests co-infection increases risks contracting sexually transmitted diseases such as HIV. The associated mechanisms...
Bladder cancers arise from transformed urothelial cells that line the bladder. These are or squamous cell carcinomas or, more rarely, additional histologic variants such as adenocarcinoma. The most important bladder cancer risk factors worldwide arguably smoking and urogenital schistosomiasis. parasitic Schistosoma haematobium worm causes schistosomiasis in approximately 112 million people, primarily sub-Saharan Africa Middle East [1]. During infection, S. worms lay highly inflammatory eggs...