A5102026520- Neural and Behavioral Psychology Studies
- EEG and Brain-Computer Interfaces
- Monoclonal and Polyclonal Antibodies Research
- Cell Adhesion Molecules Research
- Receptor Mechanisms and Signaling
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Atherosclerosis and Cardiovascular Diseases
- Computational Drug Discovery Methods
- Immunotherapy and Immune Responses
- Neural Networks and Applications
- Aeolian processes and effects
- Cultural Heritage Materials Analysis
- Phagocytosis and Immune Regulation
- Cholesterol and Lipid Metabolism
- Air Quality Monitoring and Forecasting
- Pluripotent Stem Cells Research
- MicroRNA in disease regulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Mesenchymal stem cell research
- Cancer, Lipids, and Metabolism
- Advanced biosensing and bioanalysis techniques
- Neural dynamics and brain function
- Cancer-related molecular mechanisms research
- Soil erosion and sediment transport
Tianjin Normal University
2023-2024
Northwest University
2022-2024
Ministry of Education of the People's Republic of China
2024
Wuhan University of Technology
2023
Jilin University
2018-2022
Jiangsu University
2022
Inner Mongolia Agricultural University
2020
Tsinghua University
2017-2019
Chinese Academy of Medical Sciences & Peking Union Medical College
2019
Center for Life Sciences
2017-2018
Dendritic cells are targeted by regulatory T (T reg) cells, in a manner that operates as an indirect mode of cell suppression. In this study, using combination single-cell force spectroscopy and structured illumination microscopy, we analyze individual reg cell–DC interaction events show exhibit strong intrinsic adhesiveness to DCs. This increased DC adhesion reduces the ability contacted DCs engage other antigen-specific cells. We unusually LFA-1–dependent is caused part their low calpain...
The aim of this study was to isolate and characterize porcine amniotic fluid-derived multipotent stem cells (pAF-MSC). fluid (AF) from the cavity pregnant gilts in early stages gestation (at E35) collected centrifuged for 5–10 min at 400 g pellet cells. primary culture AF showed multiple cell types, including epithelial-like fibroblast-like By culturing AMM medium 6 8 days, disappeared remaining presented fibroblastoid morphology. doubling time pAF-MSCs about 34.6 h, had been continually...
Phagocytosis is one of the earliest cellular functions, developing approximately 2 billion years ago. Although FcR-based phagocytic signaling well-studied, how it originated from ancient phagocytosis unknown. Lipid redistribution upregulates a program recapitulating with complete dependence on Src family kinases, Syk, and phosphoinositide 3-kinases (PI3K). Here we show that in phagocytes, an atypical ITAM sequence membrane anchor protein Moesin transduces signal without receptor activation....
Abstract Eucommia ulmoides Oliver is one of the commonly used traditional Chinese medicines for treatment osteoporosis, and iridoid glycosides are considered to be its active ingredients against osteoporosis. This study aims clarify chemical components molecular mechanism in osteoporosis by integrating network pharmacology simulations. The their potential targets were retrieved from text mining as well Swiss Target Prediction, TargetNet database, STITCH databases. At same time, DisGeNET,...
Allosteric ligands are promising drugs owing to their remote regulations of the orthosteric ligand signaling pathway. There few allosteric due lack handy and efficacious method for screening. Herein, we developed an affinity chromatographic screening by immobilizing purified beta2 adrenoceptor (β2-AR) onto macroporous silica gel a two-point tethering method. The relies on occupation site antagonist chelation N-terminal His-tag receptor Ni2+ coated gel. immobilized β2-AR demonstrated greatest...
Atherosclerosis is driven by an inflammatory milieu in the walls of artery vessels. Initiated early life, it progresses to plaque formation and form cell accumulation. A culprit this cascade deposition cholesterol crystals (CC). The involvement smaller stage atherosclerotic changes may be critical long-term pathological development. How these small initiate pro-inflammatory events under study. We report here unexpected mechanism that microscopic CC interact with cellular membrane a...
A new multiplex real‐time PCR assay, the high‐risk HPV genotyping real time assay (HR RT‐PCR), has been developed to detect 15 types with respective viral loads. In this report, a total of 684 cervical specimens from women diagnosed vaginitis were assessed by HR RT‐PCR and reaction reverse dot blot (PCR‐RDB) assays, using PCR‐sequencing method as reference standard. coincidence 97.7% between RT PCR‐RDB assays was determined Kappa value 0.953. The had sensitivity, specificity, concordance...
Methods of immobilized proteins are challenged by the way how to capture in their intact functional states. Here we present a two-point, high-specific method for immobilization conformationally specific angiotensin II type 1 receptor (AT1R) on amino-functionalized polystyrene microspheres. We identified selective DNA aptamer AT1R column-based SELEX approach with micromolar affinity. Two single-stranded strands were utilized introduce and 3-8 peptide microsphere surface, resulting two...
The single-cell analysis is becoming a powerful method for early detection of the abnormal variant in tissues, especially profiling small number heterogeneous cells. With advancement sequencing technologies, many types non-coding elements including miRNAs and lncRNAs which shed light on their patterns functions among cells, have been profiled at level. However, complete picture circRNA profile level still lacking. In this study, RNA-Seq data obtained from single HEK293T cells used to analyze...
Wind erosion has gained increasing attention as one of the most serious global ecological and environmental threats. Windbreaks are effective at decreasing wind by reducing speed to protect crops, livestock, farmsteads, while providing wildlife habitats. Synthetic shrubs can act novel windbreaks; however, there is limited knowledge on how their design affects speed. This study determined protective effects (airflow field sheltering efficiency) based synthetic in a tunnel. Broom-shaped...
High concentrations of ground-level ozone (O3) pose a significant threat to human health. Obtaining high-spatiotemporal-resolution information about O3 is paramount importance for pollution control. However, the current monitoring methods have lot limitations. Ground-based falls short in providing extensive coverage, and remote sensing based on satellites constrained by specific spectral bands, lacking sensitivity O3. To address this issue, we combined brightness temperature data from...
Abstract Selection history refers to the notion that previous allocations of attention or suppression have potential elicit lingering and enduring selection biases are isolated from goal-driven stimulus-driven attention. However, in singleton detection mode task, manipulating distractors cannot give rise pure proactive inhibition. Therefore, we employed a combination working memory task feature search simultaneously recording cortical activity using EEG, investigate mechanisms guided by...
Selection history is widely accepted as a vital source in attention control. Reward indicates that learned association captures even when the reward no longer presented, while statistical learning probability exerts its influence on attentional control (facilitation or inhibition). Existing research has shown effects of and are additive, suggesting these two components priority through different pathways. In current study, leveraging temporal resolution advantages EEG, we explored whether...
Atomic force microscopy based single cell spectroscopy (AFM-SCFS) is a powerful tool for studying biophysical properties of living cells. This technique allows probing interaction strengths and dynamics on live membrane, including those between cells, receptor ligands, alongside many other variations. It also works as mechanism to deliver physical or biochemical stimulus cells in spatiotemporally controlled manner, thus allowing specific activation subsequent cellular events be monitored...
The study examined human performance and related neural mechanisms in a pop-out search with different probabilities of target location the relation between feature. In array, we introduced binding two features kinds probability. Moreover, second half experiment, such probability pattern for location/feature was reversed. Behavioral results revealed successful statistical learning both absolute target’s location-feature indicated by faster RTs high-probability conditions binding. benefit...
Ancient glass is very susceptible to weathering due the buried environment, and internal elements of weathered will exchange with in environment thus leading changes composition ratio. In order classify identify objects, this paper analyzes classification laws high potassium lead-barium based on data samples known types; selects appropriate chemical for each category then divides it into subcategories, gives specific division methods establish a model, uses model artifacts unknown categories...